Abstract：
:The possible occurrence of adrenergic and non-adrenergic vasoconstrictor mechanisms has been studied in human nasal mucosa biopsies. The tissue contractions (reflecting vascular tone variation) in response to exogenous noradrenaline (NA), neuropeptide Y (NPY) and somatostatin (SOM) were measured in vitro. Dose-dependent contraction of the nasal mucosa was observed for the three agents studied and the rank order of their vasoconstrictive potency was NA > SOM > NPY. On a molar basis NPY showed an 80% less potent vasoconstrictive activity than SOM. Pretreatment with the alpha-adrenoceptor antagonist phenoxybenzamine (10(-6) M) almost completely abolished the vasoconstrictive response to NA, whereas the effects of NPY and SOM remained intact. The responses to SOM were significantly reduced after pretreatment with high dose of the competitive SOM-antagonist analog cyclo(7-aminoheptanoyl-PHE-D-TRP-LYS-THR[BZL]). When SOM was administered simultaneously with NA, the contractile response was significantly reduced as compared to the effect of NA alone. In contrast, concomitant administration of NPY and NA potentiated the vasoconstrictive effect of NA. The present data suggest that both adrenergic and non-adrenergic vasoconstrictor mechanisms are present in the human nasal mucosa vascular bed. Furthermore, NPY and SOM may act as modulators of the NA-induced vasoconstrictive effects.
journal_name
Rhinologyjournal_title
Rhinologyauthors
Fischer L,Auberson S,Bretton C,Lacroix JSsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
11-5issue
1eissn
0300-0729issn
1996-8604journal_volume
31pub_type
杂志文章相关文献
RHINOLOGY文献大全abstract：:This review is an excursion into the past to find the prototypes of the various nasal specula around the beginning of our century. The oldest prototype is documented in the ancient Hindu text Sushruta-samhita (6th century BC): a tubular nasal speculum. The bivalved forceps-like nasal speculum was mentioned by Hippocra...
journal_title：Rhinology
pub_type： 历史文章,杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:We have compared the histological aspects of nasal mucosa biopsies (n = 130) obtained during bilateral polypectomy and ethmoidectomy performed in black African (n = 50), Chinese (n = 30) and Caucasian patients (n = 50) suffering from bilateral nasal polyposis (NP). The three groups of patients were matched for age and...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:A rare case--only the fourth as known--of a nasal schwannoma with intracranial extension is presented. A 28-year-old Japanese man complained of right nasal obstruction and bleeding for one year. A biopsy indicated the presence of a nasal schwannoma. Computed tomography and magnetic resonance imaging demonstrated intra...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The objective of the study was to compare the clinical efficacy and bacteriological response of levofloxacin and amoxicillin/clavulanic acid (co-amoxiclav) in the treatment of purulent maxillary sinusitis. Sixty patients randomly received either levofloxacin 300 mg orally once daily (LEV group) or co-amoxiclav 625 mg ...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Anatomical studies of the rabbit paranasal cavities are impelled by the increasing interest in the rabbit model to investigate human sinusitis. Although several such studies have already been performed, the topography of the rabbit dorsal conchal and maxillary sinuses is described ambiguously and the existen...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin09.193
更新日期：2010-09-01 00:00:00
abstract：:After a review of the literature a modified surgical method called "bilateral bridge-flap technique" for the closure of nasoseptal perforations is outlined. After an extensive elevation of mucoperichondrium and mucoperiosteum from the entire septum as well as from the nasal roof and the nasal floor bipedicle advanceme...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Chronic rhinosinusitis (CRS) with nasal polyps is characterized by eosinophilic infiltration. This study hypothesized that the aggregation of the mucosal pathology during remodeling is related to infiltrating eosinophils in patients with such nasal polyps. OBJECT:To clarify the pathogenetic role of eosinoph...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin08.109
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Residual sleepiness after continuous positive airway pressure (CPAP) is a critical problem in some patients with obstructive sleep apnea syndrome (OSAS). However, nasal surgery is likely to reduce daytime sleepiness and feelings of unrefreshed sleep. The aim of this study is to clarify the effects of nasal su...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin17.026
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Neutrophils present as major inflammatory cells in refractory chronic rhinosinusitis with nasal polyps (CRSwNP), regardless of the endotype. However, their role in the pathophysiology of CRSwNP remains poorly understood. We investigated factors predicting the surgical outcomes of CRSwNP patients with focus o...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin20.373
更新日期：2020-10-31 00:00:00
abstract：:The therapeutic effect and adverse reactions of two antihistamines, mequitazine and dexchlorpheniramine were double-blindly compared both to placebo, to each other and to the pre-treatment status in 29 adult patients suffering from perennial rhinitis. Dexchlorpheniramine relieved the rhinitis symptoms significantly (p...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-12-01 00:00:00
abstract：:Empirical antibiotics constitute the cornerstone of medical therapy for chronic sinusitis due to difficulties of obtaining cultures from the paranasal sinuses. Indirect isolation of the pathogenic microorganisms outside the paranasal sinuses with a non-invasive method may enable administration of specific antibiotics....
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Based on the `European Position Paper on Rhinosinusitis and Nasal polyps (EP3OS 2007)`, this study aimed to investigate general practitioners (GPs) and other specialists` understanding when managing patients with acute rhinosinusitis (ARS) in Asia. METHODOLOGY:Among a total of 2662 questionnaires completed,...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino10.169
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and safety of fluticasone propionate administered using OptiNose's novel delivery device (Opt-FP) in subjects with bilateral mild-to-moderate nasal polyposis. METHODS:A prospective, multicentre, randomized, double-blind, placebo-controlled, parallel group study was conducted in adult s...
journal_title：Rhinology
pub_type： 杂志文章,随机对照试验
doi：10.4193/Rhin09.024
更新日期：2009-12-01 00:00:00
abstract：:It has been suggested but never confirmed, that the severity of the rebound swelling and rhinitis medicamentosa are directly proportional to the period during which the drug is used, to the frequency of its use, and to the amount of drug administered. However, no studies have been performed to evaluate the effects of ...
journal_title：Rhinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-03-01 00:00:00
abstract：:Massive epistaxis following blunt craniofacial trauma should alert clinicians to possible traumatic internal carotid artery (ICA) aneurysm. This article describes a case of a 46-year-old female patient with traumatic ICA pseudoaneurysm presenting similar to a sphenoid sinus mass lesion. Massive bleeding occurred durin...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Not much is known about long-term satisfaction of septoplasty. The goal of this study was to assess disease specific quality of life outcomes as well as satisfaction at more than 10 years follow-up after septoplasty. METHODOLOGY/PRINCIPAL:The study was conducted as a retrospective questionnaire study (based...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino11.218
更新日期：2012-06-01 00:00:00
abstract：:In this study we explored long term outcomes of patients with nasal stuffiness and high nasal airway resistance (NAR) that did not undergo nasal surgery. The same investigation was repeated on average 8 years after a baseline investigation with an ENT-examination, a rhinomanometric survey and a rhinomanometry. We did ...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:We have investigated a human nasal cell line, RPMI 2650 (ATCC), as an in vitro model to assess the absorption and tolerability of nasally administrated peptides. This cell line was cultured on different filters (i.e. Nunc, Costar, Falcon, Millipore, and Becton) which were uncoated or coated with collagen types I or IV...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:The authors give an account of the outcome of research done in the Allergo-Immunological Centre of the IInd ENT Division of Rome University, carried out among 210 children who were affected by nasal atopy. Particular stress was placed on the involvement of the nasopharyngo-tubal system. The age of the children ranged ...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：BACKGROUND:Allergic rhinitis (AR) is a highly prevalent disease worldwide. Although a number of studies have described AR, no studies compared children and adult AR populations. The objective was to compare the AR characteristics between two AR cohorts of children and adults. METHODS:Two AR cohorts (children and adult...
journal_title：Rhinology
pub_type： 杂志文章,多中心研究
doi：10.4193/Rhin17.074
更新日期：2017-12-01 00:00:00
abstract：:We report our experience with 10 cases of sphenoidal aspergillomas treated by endoscopic sinus surgery (ESS). Chronic symptoms such as cough, post-nasal discharge, dysphonia and even facial pain can be encountered in the history. Computerised tomography and, occasionally, magnetic resonance imaging are of great help i...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVES/HYPOTHESIS:The Modified Endoscopic Lothrop procedure (MELP) or Draf 3 is a complex procedure, performed for chronic frontal sinusitis that is refractory to standard functional endoscopic sinus surgery. The procedure involves drilling of the frontal T (formed by the septum and middle turbinate`s attachment to...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino10.248
更新日期：2011-06-01 00:00:00
abstract：:Endothelin (ET) is a newly described peptide that was isolated from the supernatant of cultured porcine aortic endothelial cells. Among the three isoforms of ET, the originally discovered ET-1 is the only one that exists in vascular endothelium. It is reported to be an extremely potent vasoconstrictor in a variety of ...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：BACKGROUND:Sinonasal inverted papillomas (SNIPs) are benign epithelial growths with high recurrence rates after surgical management. This study aims to evaluate SNIP recurrence rates after endoscopic surgery and to provide a comparison of published staging systems. METHODS:This chart review evaluated primary and revis...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhin18.039
更新日期：2018-12-01 00:00:00
abstract：:Patients requiring home oxygen can experience drying and crusting of nasal mucosa. On occasion it can be severe causing significant discomfort. In this report we present such a case. To prevent nasal airflow and hence reduce symptoms the patient was fitted with a nasal obturator. The use of the nasal obturator resulte...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：2004-12-01 00:00:00
abstract：:A technique of wedge resection is used for reduction of an extreme projection of the bony nasal pyramid. In these cases the push-down technique is inadequate, and resection of the dorsum is considered too destructive. The method consists of the resection under direct vision of a bony triangle at the base of the bony p...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:In the literature, remarks on the depiction of the anterior nasal septum in prehistoric times cannot be found. Studying works of art from some archaeological sites of Asia, Asia Minor, Near East, Egypt, and Southeastern Europe the anatomical depiction of the columella and the nostrils in human figures are shown. These...
journal_title：Rhinology
pub_type： 历史文章,杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Tritiated norepinephrine was incorporated into isolated dog nasal mucosa. Electrical stimulation of this mucosa induced a release of the tritiated norepinephrine. Acetylcholine inhibited this release in a dose-related manner. The inhibition is prevented by atropine. This data provides further evidence for the existenc...
journal_title：Rhinology
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:Prevention of chronic rhinosinusitis remains a true societal challenge, as prevention of this highly prevalent non-communicable disease will significantly reduce socio-economic costs and improve the overall well-being of the large group of affected individuals. In alignment with the health priorities of national gover...
journal_title：Rhinology
pub_type： 社论
doi：10.4193/Rhin18.404
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:This study investigates how deviated nasal septum affects the quantity and distribution of spray particles, and examines the effects of inspiratory airflow and head position on particle transport. METHODS:Deposition of spray particles was analysed using a three-dimensional computational fluid dynamics model...
journal_title：Rhinology
pub_type： 杂志文章
doi：10.4193/Rhino12.053
更新日期：2012-09-01 00:00:00
