Human genetic variation altering anthrax toxin sensitivity.

abstract：:The Sleeping Beauty (SB) transposon system can integrate foreign sequences of DNA in the genome of mouse somatic cells eliciting long-term expression in vivo. This technology holds great promise for human gene therapy as a nonviral technology to deliver therapeutic genes. SB also provides a means to study the effects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlson CM,Frandsen JL,Kirchhof N,McIvor RS,Largaespada DA

更新日期：2005-11-22 00:00:00

abstract：:Mouse granulocyte-macrophage progenitor cells were stimulated to divide by the granulocyte-macrophage colony-stimulating factor (GM-CSF). The two daughter cells were separated; one daughter was transferred to medium containing a high concentration of GM-CSF, the other to medium containing a low concentration. Daughter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D

更新日期：1980-09-01 00:00:00

abstract：:Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which results in altered social behaviors of piglet offspring. These behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antonson AM,Lawson MA,Caputo MP,Matt SM,Leyshon BJ,Johnson RW

更新日期：2019-10-01 00:00:00

abstract：:The amount of information that can be stored in working memory is limited but may be improved with practice. The basis of improved efficiency at the level of neural activity is unknown. To investigate this question, we trained monkeys to perform a working memory task that required memory for multiple stimuli. Performa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang H,Qi XL,Riley MR,Constantinidis C

更新日期：2019-04-02 00:00:00

abstract：:Purified fractions of human apotransferrin, monoferric transferrins with iron on the acid-labile binding site and on the acid-stable binding site, and diferric transferrin have been prepared. The iron loading and unloading behavior of these preparations has been examined by isoelectric focusing. Iron release from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebers H,Josephson B,Huebers E,Csiba E,Finch C

更新日期：1981-04-01 00:00:00

abstract：:By harnessing the oxidative power of microorganisms, energy can be recovered from reservoirs of less-concentrated organic matter, such as marine sediment, wastewater, and waste biomass. Left unmanaged, these reservoirs can become eutrophic dead zones and sites of greenhouse gas generation. Here, we introduce a unique ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie X,Ye M,Hsu PC,Liu N,Criddle CS,Cui Y

更新日期：2013-10-01 00:00:00

abstract：:Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CS,Hsu SJ,Chen HC,Tseng TC,Liu CH,Niu WF,Jeng J,Liu CJ,Lai MY,Chen PJ,Kao JH,Chen DS

更新日期：2011-03-01 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:Langerhans cells are a subset of dendritic cells (DCs) found in the human epidermis with unique morphological and molecular properties that enable their function as "sentinels" of the immune system. DCs are pivotal in the initiation and regulation of primary MHC class I restricted T lymphocyte immune responses and are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacAry PA,Lindsay M,Scott MA,Craig JI,Luzio JP,Lehner PJ

更新日期：2001-03-27 00:00:00

abstract：:The regulation of cellular protein levels is a complex process involving many regulatory mechanisms, each introducing stochastic events, leading to variability of protein levels between isogenic cells. Previous studies have shown that perturbing genes involved in transcription regulation affects the amount of cell-to-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinott R,Jaimovich A,Friedman N

更新日期：2011-04-12 00:00:00

abstract：:Inhomogeneous ab initio molecular dynamics simulations show that vaporization of MgSiO3 is incongruent and that the vapor phase is dominated by SiO and O2 molecules. The vapor is strongly depleted in Mg at low temperature and approaches the composition of the liquid near the critical point. We find that the liquid-vap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao B,Stixrude L

更新日期：2018-05-22 00:00:00

abstract：:Aire induces ectopic expression of peripheral tissue antigens (PTAs) in thymic medullary epithelial cells, which promotes immunological tolerance. Beginning with a broad screen of histone peptides, we demonstrate that the mechanism by which this single factor controls the transcription of thousands of genes involves r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koh AS,Kuo AJ,Park SY,Cheung P,Abramson J,Bua D,Carney D,Shoelson SE,Gozani O,Kingston RE,Benoist C,Mathis D

更新日期：2008-10-14 00:00:00

abstract：:A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with one-hit kinetics in both human embryonic kidney and African green monkey kidney cells, induces an SV40 specific antigen which is detectable by immunofluorescence and complement-fixation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis AM Jr,Levin MJ,Wiese WH,Crumpacker CS,Henry PH

更新日期：1969-08-01 00:00:00

abstract：:The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5', C-1', and C-4' positions of deoxyribose on each strand. In a dodecamer oligodeoxyribonucleotide containing the sequence AGC.GCT, a bistranded lesion staggered two nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kappen LS,Goldberg IH

更新日期：1992-08-01 00:00:00

abstract：:Certain chemical systems which differ greatly in many of their chemical properties may nevertheless exhibit stereochemically isomorphic behavior, i.e., they may be stereochemically correspondent. Two such systems are spirocyclic pentacoordinate molecules and molecules of the type Ar(2)ZX. The consequences of stereoche...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gust D,Finocchiaro P,Mislow K

更新日期：1973-12-01 00:00:00

abstract：:The etiology of Alzheimer disease is unclear. However, immunological aberrations have been suggested to be critical factors in the pathogenesis of this neurodegenerative disease. This study was carried out to investigate if cerebrospinal fluid (CSF) from Alzheimer disease patients contains antibodies that recognize sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McRae-Degueurce A,Booj S,Haglid K,Rosengren L,Karlsson JE,Karlsson I,Wallin A,Svennerholm L,Gottfries CG,Dahlstrom A

更新日期：1987-12-01 00:00:00

abstract：:Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-like loci and a mechanism for silencing two of them. How this system originated is unknown, because the three-locus system is present throughout the family Saccharomycetace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanson SJ,Byrne KP,Wolfe KH

更新日期：2014-11-11 00:00:00

abstract：:The recognition of carrier proteins by multiple catalytic partners occurs in every cycle of chain elongation in the biosynthesis of fatty acids and of the pharmacologically important polyketide and nonribosomal peptide natural products. To dissect the features of carrier proteins that determine specific recognition at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Z,Lai JR,Walsh CT

更新日期：2007-07-10 00:00:00

abstract：:By examining many alternative arrangements of cortical areas, we have found that the arrangement actually present in the brain minimizes the volume of the axons required for interconnecting the areas. Our observations support the notion that the organization of cortical areas has evolved to optimize interareal connect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klyachko VA,Stevens CF

更新日期：2003-06-24 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a genetic disorder caused by loss of the protein dystrophin. In humans, DMD has early onset, causes developmental delays, muscle necrosis, loss of ambulation, and death. Current animal models have been challenged by their inability to model the early onset and severity of the disea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes KJ,Rodriguez A,Flatt KM,Ray S,Schuler A,Rodemoyer B,Veerappan V,Cuciarone K,Kullman A,Lim C,Gutta N,Vemuri S,Andriulis V,Niswonger D,Barickman L,Stein W,Singhvi A,Schroeder NE,Vidal-Gadea AG

更新日期：2019-02-26 00:00:00

abstract：:During the last several decades corals have been in decline and at least one-third of all coral species are now threatened with extinction. Coral disease has been a major contributor to this threat, but little is known about the responsible pathogens. To date most research has focused on bacterial and fungal diseases;...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vega Thurber RL,Barott KL,Hall D,Liu H,Rodriguez-Mueller B,Desnues C,Edwards RA,Haynes M,Angly FE,Wegley L,Rohwer FL

更新日期：2008-11-25 00:00:00

abstract：:Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile."...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strang CJ,Siegel RC,Phillips ML,Poon PH,Schumaker VN

更新日期：1982-01-01 00:00:00

abstract：:The human placental alkaline phosphatase gene has been cloned and reintroduced into mammalian cells. When a plasmid carrying the gene under control of the simian virus 40 early promoter (pSV2Apap) is transfected into a variety of different cell types, placental alkaline phosphatase activity can readily be detected by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henthorn P,Zervos P,Raducha M,Harris H,Kadesch T

更新日期：1988-09-01 00:00:00

abstract：:The involvement of gangliosides in processes related to nerve regeneration and sprouting has been demonstrated recently. The type of interaction by which gangliosides may influence neuronal sprouting was investigated in the present work. Affinity-purified rabbit anti-GM1 antibodies were found to block the sprouting fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz M,Spirman N

更新日期：1982-10-01 00:00:00

abstract：:Thyroid hormone (TH) metabolism, mediated by deiodinase types 1, 2, and 3 (D1, D2, and D3) is profoundly affected by acute illness. We examined the role of TH metabolism during ventilator-induced lung injury (VILI) in mice. Mice exposed to VILI recapitulated the serum TH findings of acute illness, namely a decrease in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barca-Mayo O,Liao XH,DiCosmo C,Dumitrescu A,Moreno-Vinasco L,Wade MS,Sammani S,Mirzapoiazova T,Garcia JG,Refetoff S,Weiss RE

更新日期：2011-12-06 00:00:00

abstract：:The Mpemba effect occurs when a hot system cools faster than an initially colder one, when both are refrigerated in the same thermal reservoir. Using the custom-built supercomputer Janus II, we study the Mpemba effect in spin glasses and show that it is a nonequilibrium process, governed by the coherence length ξ of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baity-Jesi M,Calore E,Cruz A,Fernandez LA,Gil-Narvión JM,Gordillo-Guerrero A,Iñiguez D,Lasanta A,Maiorano A,Marinari E,Martin-Mayor V,Moreno-Gordo J,Muñoz Sudupe A,Navarro D,Parisi G,Perez-Gaviro S,Ricci-Tersenghi F,Rui

更新日期：2019-07-30 00:00:00

abstract：:Noniridescent coloration by the spongy keratin in parrot feather barbs has fascinated scientists. Nonetheless, its ultimate origin remains as yet unanswered, and a quantitative structural and optical description is still lacking. Here we report on structural and optical characterizations and numerical simulations of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yin H,Dong B,Liu X,Zhan T,Shi L,Zi J,Yablonovitch E

更新日期：2012-07-03 00:00:00

abstract：:Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to colorectal cancer tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fearnhead NS,Wilding JL,Winney B,Tonks S,Bartlett S,Bicknell DC,Tomlinson IP,Mortensen NJ,Bodmer WF

更新日期：2004-11-09 00:00:00

abstract：:The dramatic increase in healthcare cost has become a significant burden to the world. Many patients are denied the accessibility of medication because of the high price of drugs. Total biosynthesis of chiral drug intermediates is an environmentally friendly approach that helps provide more affordable pharmaceuticals....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang K,Li H,Cho KM,Liao JC

更新日期：2010-04-06 00:00:00

abstract：:Isolates of rhinovirus C (RV-C), a recently identified Enterovirus (EV) species, are the causative agents of severe respiratory infections among children and are linked to childhood asthma exacerbations. The RV-C have been refractory to structure determination because they are difficult to propagate in vitro. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Hill MG,Klose T,Chen Z,Watters K,Bochkov YA,Jiang W,Palmenberg AC,Rossmann MG

更新日期：2016-08-09 00:00:00