当前位置： SCI文献检索 > CLINICAL NUCLEAR MEDICINE期刊下所有文献 > ⁶⁸Ga-DOTANOC PET/CT in patients with carcinoma of unknown primary of neuroendocrine origin.

⁶⁸Ga-DOTANOC PET/CT in patients with carcinoma of unknown primary of neuroendocrine origin.

Abstract：

OBJECTIVE:To evaluate the role of ⁶⁸Ga-DOTANOC (⁶⁸Gallium-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI³-octreotide) PET/CT for localization of the primary tumor in patients with carcinoma of unknown primary of neuroendocrine origin. MATERIAL AND METHODS:Twenty patients (median age, 55 years; male 10) with histopathologically proven metastatic neuroendocrine tumor and no localization of primary tumor on conventional imaging were included in the study. PET/CT was done after injection of 132-222 MBq (4-6 mCi) of ⁶⁸Ga-DOTANOC. Images were evaluated by 2 experienced nuclear medicine physicians both qualitatively as well as quantitatively (maximum standardized uptake value). Histopathology (when available) and/or follow-up imaging with biochemical markers were taken as reference standard. RESULTS:⁶⁸Ga-DOTANOC PET/CT localized the primary tumor in 12/20 (60%) patients. Midgut was the most common site of primary tumor (n = 9); duodenum (4), ileum (4), and colon (1). In 1 patient each the primary was localized to the pancreas, stomach, and lung. In these 12 patients, significant correlation was found between maximum standardized uptake value of primary tumor and metastasis (ρ = 0.615; P = 0.041). Even in patients in whom no primary tumor was localized, additional sites of metastatic disease were observed when compared with conventional imaging, mostly in lymph nodes and bones. There was a change in management in 3/20 patients (15%), who underwent surgery. In the remaining 17 patients, demonstration of somatostatin receptor expression by PET/CT made them suitable candidate for peptide receptor radionuclide therapy. CONCLUSION:⁶⁸Ga-DOTANOC PET/CT seems to be a promising modality for detecting primary tumor in patients with carcinoma of unknown primary of neuroendocrine origin.

journal_name

Clin Nucl Med

journal_title

Clinical nuclear medicine

authors

Naswa N,Sharma P,Kumar A,Soundararajan R,Kumar R,Malhotra A,Ammini AC,Bal C

doi

10.1097/RLU.0b013e31823ea730

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

245-51

issue

eissn

0363-9762

issn

1536-0229

pii

00003072-201203000-00005

journal_volume

pub_type

杂志文章

在线工具

⁶⁸Ga-DOTANOC PET/CT in patients with carcinoma of unknown primary of neuroendocrine origin.