A case of gas gangrene in an immunosuppressed Crohn's patient.

Abstract:

:Clostridium septicum (C. septicum) gas gangrene is well documented in the literature, typically in the setting of trauma or immunosuppression. In this paper, we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazine-induced neutropenia. The patient presented with left thigh pain, vomiting and diarrhea. Blood tests demonstrated a profound neutropenia, and magnetic resonance imaging of the thigh confirmed extensive myonecrosis. The patient underwent emergency hip disarticulation, followed by hemicolectomy. C. septicum was cultured from the blood. Following completion of antibiotic therapy, the patient developed myonecrosis of the right pectoral muscle necessitating further debridement, and remains on lifelong prophylactic antibiotic therapy.

journal_name

World J Gastroenterol

authors

Kiel N,Ho V,Pascoe A

doi

10.3748/wjg.v17.i33.3856

subject

Has Abstract

pub_date

2011-09-07 00:00:00

pages

3856-8

issue

33

eissn

1007-9327

issn

2219-2840

journal_volume

17

pub_type

杂志文章
  • Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior.

    abstract:AIM:To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior. METHODS:Twenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i25.4615

    authors: Hwang J,Kim JS,Kim AY,Lim JS,Kim SH,Kim MJ,Kim MS,Song KD,Woo JY

    更新日期:2017-07-07 00:00:00

  • Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy: A debate near the end.

    abstract::Direct acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection, achieving high rates (≥ 95%) of sustained virological response, with a good safety profile and high compliance rates. Consequently, it had been expected that viral clearance will reduce morbidity and mortality rates...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v26.i43.6770

    authors: Muzica CM,Stanciu C,Huiban L,Singeap AM,Sfarti C,Zenovia S,Cojocariu C,Trifan A

    更新日期:2020-11-21 00:00:00

  • Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia.

    abstract:AIM:To demonstrate the possible associations between genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2) and esophageal squamous cell dysplasia (ESCD). METHODS:All participants came from an area of high incidence of esophageal cancer and underwent an endoscopic staining examination; biopsies were taken from a no...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i27.3445

    authors: Zhou YZ,Diao YT,Li H,Li HQ,Ma Q,Cui J

    更新日期:2010-07-21 00:00:00

  • Technical skills and training of upper gastrointestinal endoscopy for new beginners.

    abstract::The incidence of gastric cancer remains high in South Korea. Upper gastrointestinal (GI) endoscopy, i.e., esophagogastroduodenoscopy (EGD), has a higher diagnostic specificity and sensitivity than the upper GI series. Additionally, EGD has the ability to biopsy, through taking a tissue of the pathologic lesion. Succes...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i3.759

    authors: Lee SH,Park YK,Cho SM,Kang JK,Lee DJ

    更新日期:2015-01-21 00:00:00

  • Hemihepatic versus total hepatic inflow occlusion during hepatectomy: a systematic review and meta-analysis.

    abstract:AIM:To evaluate the clinical outcomes of patients undergoing hepatectomy with hemihepatic vascular occlusion (HHO) compared with total hepatic inflow occlusion (THO). METHODS:Randomized controlled trials (RCTs) comparing hemihepatic vascular occlusion and total hepatic inflow occlusion were included by a systematic li...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v17.i26.3158

    authors: Wang HQ,Yang JY,Yan LN

    更新日期:2011-07-14 00:00:00

  • Clinical evaluation of serum concentrations of intercellular adhesion molecule-1 in patients with colorectal cancer.

    abstract:AIM:To investigate the correlation between the serum soluble intercellular adhesion molecule-1 (sICAM-1) and the clinicopathologic features and to evaluate the possible prognostic significance of sICAM-1 concentration in colorectal cancer. METHODS:A total of 56 patients (mean age 57.3 years) having transitional cell c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i27.4250

    authors: Kang X,Wang F,Xie JD,Cao J,Xian PZ

    更新日期:2005-07-21 00:00:00

  • Importance of nutrition in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) results from the interaction between an individual's immune response and precipitant environmental factors, which generate an anomalous chronic inflammatory response in those who are genetically predisposed. Various feeding practices have been implicated in the origin of IBD based on e...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.15.2081

    authors: Lucendo AJ,De Rezende LC

    更新日期:2009-05-07 00:00:00

  • Genetic susceptibility and environmental factors of esophageal cancer in Xi'an.

    abstract:AIM:To analyse the role of genetic susceptibility and environmental factors in the process of esophageal cancer (EC) formation in Xi'an, China. METHODS:A hospital based case-control study, combined with molecular epidemiological method, was carried out. A total of 127 EC cases and 101 controls were interviewed with qu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i7.940

    authors: Wang AH,Sun CS,Li LS,Huang JY,Chen QS,Xu DZ

    更新日期:2004-04-01 00:00:00

  • Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.

    abstract:AIM:To study the effects of IkappaBalpha and its mutants (IkappaBalphaM, IkappaBalpha243N, IkappaBalphaM244C) on NF-kappaB, p53 and their downstream target genes. The relationship of NF-kappaB, p53, and IkappaBalpha was further discussed. METHODS:pECFP-IkappaBalpha, pECFP-IkappaBalphaM (amino acides 1-317, Ser32, 36A)...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i41.6658

    authors: Li X,Xing D,Wang J,Zhu DB,Zhang L,Chen XJ,Sun FY,Hong A

    更新日期:2006-11-07 00:00:00

  • Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: a systematic review.

    abstract::Despite advances in the management of patients with locally advanced, non-metastatic rectal adenocarcinoma (LARC), prognosis remains largely unsatisfactory due to a high rate of distant relapse. In fact, currently available neoadjuvant protocols, represented by fluoropyrimidine-based chemo-radiotherapy (CT-RT) or shor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i20.6081

    authors: Fornaro L,Caparello C,Vivaldi C,Rotella V,Musettini G,Falcone A,Baldini E,Masi G

    更新日期:2014-05-28 00:00:00

  • Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma.

    abstract:BACKGROUND:Accumulating evidence has revealed that several long non-coding ribonucleic acids (lncRNAs) are crucial in the progress of hepatocellular carcinoma (HCC). AIM:To classify a long non-coding RNA, i.e., lncRNA W5, and to determine the clinical significance and potential roles of lncRNA W5 in HCC. METHODS:The ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v27.i1.55

    authors: Lei GL,Fan HX,Wang C,Niu Y,Li TL,Yu LX,Hong ZX,Yan J,Wang XL,Zhang SG,Ren MJ,Yang PH

    更新日期:2021-01-07 00:00:00

  • Laparoscopic partial resection for hemangioma in the third portion of the duodenum.

    abstract::Benign duodenal tumors are rare and less common than malignant tumors. Furthermore, vascular lesions of the duodenum, including hemangiomas, are rare causes of gastrointestinal bleeding. This report describes a case with bleeding hemangiomas in the third portion of the duodenum and jejunum and their successful treatme...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i34.12341

    authors: Kanaji S,Nakamura T,Nishi M,Yamamoto M,Kanemitu K,Yamashiita K,Imanishi T,Sumi Y,Suzuki S,Tanaka K,Kakeji Y

    更新日期:2014-09-14 00:00:00

  • Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections.

    abstract::The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745: (1) An actio...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v25.i18.2188

    authors: Czerucka D,Rampal P

    更新日期:2019-05-14 00:00:00

  • Hepatitis C virus: virology, diagnosis and management of antiviral therapy.

    abstract::Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylated interferon alfa and ribavirin. The use of serological and virological tests has become essential in the management of HCV infection ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v13.i17.2461

    authors: Chevaliez S,Pawlotsky JM

    更新日期:2007-05-07 00:00:00

  • Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

    abstract::Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i12.2124

    authors: Rapozo DC,Bernardazzi C,de Souza HS

    更新日期:2017-03-28 00:00:00

  • Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.

    abstract:AIM:To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC). METHODS:Liver biopsies and HCC specimens from patients were collected and histologically examined. The expression of PD-1, PD-L1, and PD-L...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i28.3322

    authors: Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL

    更新日期:2011-07-28 00:00:00

  • Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival.

    abstract:AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma (PDAC) and to determine whether RASSF6 has an independent prognostic value in PDAC. METHODS:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quanti...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i21.6621

    authors: Ye HL,Li DD,Lin Q,Zhou Y,Zhou QB,Zeng B,Fu ZQ,Gao WC,Liu YM,Chen RW,Li ZH,Chen RF

    更新日期:2015-06-07 00:00:00

  • Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis.

    abstract:BACKGROUND:To date, the histopathological parameters predicting the risk of lymph node (LN) metastases and local recurrence, associated mortality and appropriateness of endoscopic or surgical resection in patients with gastric neuroendocrine neoplasms type 1 (GNENs1) have not been fully elucidated. AIM:To determine th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3748/wjg.v25.i35.5376

    authors: Tsolakis AV,Ragkousi A,Vujasinovic M,Kaltsas G,Daskalakis K

    更新日期:2019-09-21 00:00:00

  • Mucinous cyst exhibiting severe dysplasia in gastric heterotopic pancreas associated with gastrointestinal stromal tumour.

    abstract::Heterotopic pancreatic tissue within the stomach is rare and dysplasia within heterotopic pancreatic tissue is very rare. We present the first report of a patient with concurrent occurrence of heterotopic pancreas in the stomach with a gastrointestinal stromal tumour. ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i43.5781

    authors: Kaufman A,Storey D,Lee CS,Murali R

    更新日期:2007-11-21 00:00:00

  • Preoperative therapy in locally advanced esophageal cancer.

    abstract::Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer (T2 or greater or node positive); howe...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i39.8750

    authors: Garg PK,Sharma J,Jakhetiya A,Goel A,Gaur MK

    更新日期:2016-10-21 00:00:00

  • American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings.

    abstract:AIM:To investigate whether American ginseng (AG, Panax quinquefolium) supplementation was able to improve endurance exercise performance. METHODS:Thirteen physically active male college students were divided into two groups (AG or placebo) and received supplementation for 4 wk, before the exhaustive running exercise. ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3748/wjg.v11.i34.5327

    authors: Hsu CC,Ho MC,Lin LC,Su B,Hsu MC

    更新日期:2005-09-14 00:00:00

  • Establishment of mouse intestinal myofibroblast cell lines.

    abstract:AIM:To establish novel intestinal myofibroblast (IMF) cell lines from mouse colonic mucosa and investigate their biological characters. METHODS:Primary IMFs were isolated from mucosal tissues of mouse colon that was denuded of epithelial cells and smooth muscle layer. For immortalization, primary IMFs were transfected...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i17.2629

    authors: Kawasaki H,Ohama T,Hori M,Sato K

    更新日期:2013-05-07 00:00:00

  • Relationship between serum calcium and CA 19-9 levels in colorectal cancer.

    abstract:AIM:To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients. METHODS:Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium o...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i13.1890

    authors: Fuszek P,Lakatos P,Tabak A,Papp J,Nagy Z,Takacs I,Horvath HC,Lakatos PL,Speer G

    更新日期:2004-07-01 00:00:00

  • Necrosis of a large hepatic tumor after hemorrhage and subsequent selective arterial embolization.

    abstract::This case report describes a young female patient presenting with acute intra-abdominal hemorrhage originating from a large tumor in the liver, most likely a hepatocellular adenoma. The bleeding was stopped by selective embolization of right hepatic artery branches. Subsequently, partial hepatectomy was performed afte...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i37.6059

    authors: Huurman VA,Stoot JH,van der Linden E,Terpstra OT,Schaapherder AF

    更新日期:2006-10-07 00:00:00

  • Treatment responses in Asians and Caucasians with chronic hepatitis C infection.

    abstract:AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C (CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians. METHODS:Asian patients infected with genotype 1 CHC treated at 4 A...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.14.3416

    authors: Yan KK,Guirgis M,Dinh T,George J,Dev A,Lee A,Zekry A

    更新日期:2008-06-07 00:00:00

  • Impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy on hepatocellular carcinoma cell killing.

    abstract:AIM:To explore the impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy (IMRT) on cell killing of human hepatocellular carcinoma (HCC) HepG2 and Hep3B cell lines. METHODS:The radiobiological characteristics of human HCC HepG2 and Hep3b cell lines were studied with standard clo...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i10.1452

    authors: Zheng XK,Chen LH,Yan X,Wang HM

    更新日期:2005-03-14 00:00:00

  • Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.

    abstract::To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and S...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.14.4721

    authors: Schimanski CC,Galle PR,Moehler M

    更新日期:2008-08-14 00:00:00

  • Strangulated small bowel hernia through the port site: a case report.

    abstract::Port site hernia develops through a fascial or peritoneal layer that was inadequate or not repaired. It is a rare complication of laparoscopic surgery which may lead to serious problems. Here, we present a 77-year-old female, diagnosed with a small bowel hernia through a 10-mm port site. We had performed ten cases of ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6881

    authors: Lee JH,Kim W

    更新日期:2008-11-28 00:00:00

  • Molecular mechanisms of peritoneal dissemination in gastric cancer.

    abstract::Peritoneal dissemination represents a devastating form of gastric cancer (GC) progression with a dismal prognosis. There is no effective therapy for this condition. The 5-year survival rate of patients with peritoneal dissemination is 2%, even including patients with only microscopic free cancer cells without macrosco...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i30.6829

    authors: Kanda M,Kodera Y

    更新日期:2016-08-14 00:00:00

  • Interleukin-28 and hepatitis C virus genotype-4: treatment-induced clearance and liver fibrosis.

    abstract:AIM:To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS:Two hundred and one HCV-genotype 4 patients were included. All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk. End...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i47.7003

    authors: Derbala M,Rizk N,Shebl F,Alkaabi S,Eldweik N,John A,Sharma M,Yaqoob R,Almohanadi M,Butt M,Alejji K

    更新日期:2012-12-21 00:00:00