Regulation of α-secretase ADAM10 expression and activity.

abstract：:The intracortical arborizations of thalamocortical fibers arising from the ventroposterolateral (VPL) nucleus in the cat were studied following intra-axonal injections of horseradish peroxidase (HRP). The axons were impaled 1.5 to 3 mm below the surface of the cortex, identified electrophysiologically by stimulating t...

journal_title：Experimental brain research

authors： Landry P,Diadori P,Leclerc S,Dykes RW

更新日期：1987-01-01 00:00:00

abstract：:Stroke is one of the leading causes of mortality and morbidity in advanced countries of the world. Despite the fact that reactive oxygen and nitrogen species (ROS and RNS) are the by-products of normal metabolic processes and mediate important physiological processes, they can inflict damage to the cell if produced in...

journal_title：Experimental brain research

authors： Saeed SA,Shad KF,Saleem T,Javed F,Khan MU

更新日期：2007-09-01 00:00:00

abstract：:The foot is a critical interface between the body and supporting surface during walking, but there is no coherent framework on which to model the dynamics of the stance and swing phases. To establish this framework, we studied the rotational and translational dynamics of foot movement in three dimensions with a motion...

journal_title：Experimental brain research

authors： Osaki Y,Kunin M,Cohen B,Raphan T

更新日期：2007-01-01 00:00:00

abstract：:Previous work has indicated that people do not use their judgment of a target's speed to determine where to hit it. Instead, they use their judgment of the target's changing position and an expected speed (based on the speed of previous targets). In the present study we investigate whether people also ignore the targe...

journal_title：Experimental brain research

authors： Brouwer AM,Middelburg T,Smeets JB,Brenner E

更新日期：2003-10-01 00:00:00

abstract：:Transcranial magnetic stimulation (TMS) applied over the occipital lobe approximately 100 ms after the onset of a stimulus decreases its visibility if it appears in the location of the phosphene. Because phosphenes can also be elicited by stimulation of the parietal regions, we asked if the same procedure that is used...

journal_title：Experimental brain research

authors： Tapia E,Mazzi C,Savazzi S,Beck DM

更新日期：2014-06-01 00:00:00

abstract：:Cultured olfactory bulb cells from embryonic mice had ultrastructural characteristics similar to those of many cell types in the intact adult mouse olfactory bulb. Identified cultured cells included mitral/tufted cells, granule cells, short-axon cells, and fibrous and protoplasmic astrocytes. Cultured neurons were fou...

journal_title：Experimental brain research

authors： Fracek SP Jr,Guo L,Schafer R

更新日期：1994-01-01 00:00:00

abstract：:The effects on striatal high affinity glutamate uptake (HAGU) of an apomorphine injection administered either alone or along with an electrical stimulation of the frontal cortex were compared between intact control rats and animals with 6-hydroxydopamine (6-OHDA) induced lesions of the nigrostriatal dopaminergic neuro...

journal_title：Experimental brain research

authors： Kerkerian L,Nieoullon A

更新日期：1988-01-01 00:00:00

abstract：:Is it possible to learn to perform a motor sequence without awareness of the sequence? In two experiments, we presented participants with the most elementary sequence: an alternation between two options. We used a double-step pointing task in which the final position of the target alternated between two quite similar ...

journal_title：Experimental brain research

authors： Oostwoud Wijdenes L,Brenner E,Smeets JB

更新日期：2016-06-01 00:00:00

abstract：:The flexion reflex modulation pattern was investigated in nine people with a chronic spinal cord injury during stepping using body weight support on a treadmill and manual assistance by therapists. Body weight support was provided by an upper body harness and was adjusted for each subject to promote the best stepping ...

journal_title：Experimental brain research

authors： Knikou M,Angeli CA,Ferreira CK,Harkema SJ

更新日期：2009-07-01 00:00:00

abstract：:Saslow and others have shown that the latency of foveating saccades can be altered by changing the offset time of the current fixation point relative to the onset of the peripheral target. Whether anticipatory saccades contributed to these results was not known. By the criteria of direction error and amplitude error t...

journal_title：Experimental brain research

authors： Kalesnykas RP,Hallett PE

更新日期：1987-01-01 00:00:00

abstract：:A photographic technique was used to study the evolution of lateral head-tilt following hemilabyrinthectomy in adult cats. Animals were maintained post-operatively in normally lit conditions (LM cats), in total darkness (DM cats), or in stroboscopic light. In LM casts, the head tilt peaked at 45 degrees (with the lesi...

journal_title：Experimental brain research

authors： Putkonen PT,Courjon JH,Jeannerod M

更新日期：1977-06-27 00:00:00

abstract：:The extent to which attending to one stimulus while ignoring another influences the integration of visual and inertial (vestibular, somatosensory, proprioceptive) stimuli is currently unknown. It is also unclear how cue integration is affected by an awareness of cue conflicts. We investigated these questions using a t...

journal_title：Experimental brain research

authors： Berger DR,Bülthoff HH

更新日期：2009-09-01 00:00:00

abstract：:The presence of discrete events during an interval to be estimated generally causes a dilation of perceived duration (event-filling effect). Here, we investigated this phenomenon in the thermal modality using multi-seconds (19 s) innocuous cool stimuli that were either constant (continuous interval) or fluctuating to ...

journal_title：Experimental brain research

authors： Khoshnejad M,Martinu K,Grondin S,Rainville P

更新日期：2016-04-01 00:00:00

abstract：:We investigated whether the control of movement of the left hand is more likely to involve the use of allocentric information than movements performed with the right hand. Previous studies (Gonzalez et al. in J Neurophys 95:3496-3501, 2006; De Grave et al. in Exp Br Res 193:421-427, 2009) have reported contradictory f...

journal_title：Experimental brain research

authors： van der Kamp J,de Wit MM,Masters RS

更新日期：2012-04-01 00:00:00

abstract：:Chronic loss of vestibular function modifies the role of neck afferents in human perception of self-motion. We characterized this change by comparing the self-motion perception of patients with chronic vestibular loss (Ps) to that of normal subjects (Ns). Stimuli consisted of sinusoidal horizontal rotations (0.025-0.4...

journal_title：Experimental brain research

authors： Schweigart G,Heimbrand S,Mergner T,Becker W

更新日期：1993-01-01 00:00:00

abstract：:Recent animal studies have found neuronal expression of major histocompatibility complex (MHC) class I in the central nervous system (CNS). However, the developmental expression profiles of MHC class I in human CNS remain unclear. Here, we systemically evaluate the expression and subcellular localization of MHC class ...

journal_title：Experimental brain research

authors： Zhang A,Yu H,He Y,Shen Y,Zhang Y,Liu J,Fu B,Lv D,Miao F,Zhang J

更新日期：2015-09-01 00:00:00

abstract：:The aim of this study was to examine how adults processed common fractions with common numerators under two distinct conditions. Whereas participants were presented with only common fractions in a "simple" condition, a "complex" condition involved the random presentation of common fractions as well as decimal fraction...

journal_title：Experimental brain research

authors： Zhang L,Xin Z,Li F,Wang Q,Ding C,Li H

更新日期：2012-03-01 00:00:00

abstract：:We studied characteristics of digit action and their co-variation patterns across trials (prehension synergies) during static holding of an object while the external torque could change slowly and smoothly. The subjects held in the air an instrumented handle with an attachment that allowed a smooth change in the exter...

journal_title：Experimental brain research

authors： Sun Y,Park J,Zatsiorsky VM,Latash ML

更新日期：2011-09-01 00:00:00

abstract：:(1) The responses of CA1 pyramidal cells to short glutamate pulses (10-50 ms) delivered at sensitive spots in the apical dendrites have been analysed by intracellular recording. (2) The glutamate pulses elicited stable depolarizing responses in a dose- and frequency-dependent manner. (3) When a single action potential...

journal_title：Experimental brain research

authors： Hu GY,Hvalby O

更新日期：1992-01-01 00:00:00

abstract：:Activation of glial cells has been proposed to contribute to neuronal dysfunction and neuronal cell death in Alzheimer's disease. In this study, we attempt to determine some of the effects of secreted factors from activated murine N-11 microglia on viability and morphology of neurons using the differentiated neuroblas...

journal_title：Experimental brain research

authors： Münch G,Gasic-Milenkovic J,Dukic-Stefanovic S,Kuhla B,Heinrich K,Riederer P,Huttunen HJ,Founds H,Sajithlal G

更新日期：2003-05-01 00:00:00

abstract：:In order to navigate efficiently, animals can benefit from internal representations of their moment-to-moment orientation. Head-direction (HD) cells are neurons that discharge maximally when the head of a rat is oriented in a specific ("preferred") direction in the horizontal plane, independently from position or ongo...

journal_title：Experimental brain research

authors： Zugaro MB,Tabuchi E,Wiener SI

更新日期：2000-07-01 00:00:00

abstract：:The possibility of a cerebellar linkage, via the thalamus with medial area 6 of the cerebral cortex was further explored in the present experiments (cf. preceding companion paper). It was found that HRP conjugated to the lectin wheat germ agglutinin injected into motor cortical areas was transported beyond the thalamu...

journal_title：Experimental brain research

authors： Wiesendanger R,Wiesendanger M

更新日期：1985-01-01 00:00:00

abstract：:Human subjects attempted to modify their vestibuloocular reflex (VOR) in the dark by fixating imagined targets while experiencing predictable (SIN) sinusoidal (0.01-2.5 Hz) and unpredictable (SSN) sum of sines rotational stimuli (0.02-1.9 Hz). Modification was attempted under 2 instructional sets: VOR enhancement, ie ...

journal_title：Experimental brain research

authors： McKinley PA,Peterson BW

更新日期：1985-01-01 00:00:00

abstract：:We have studied the contribution of feedback signals originating from one of the "form-processing" extrastriate cortical areas, area 21a (A21a), to orientation selectivity of single neurons in the ipsilateral area 17 (A17). Consistent with previous findings, reversible inactivation (cooling to 5-10 degrees C) of area ...

journal_title：Experimental brain research

authors： Wang C,Waleszczyk WJ,Burke W,Dreher B

更新日期：2007-10-01 00:00:00

abstract：:This study employed neurophysiological methods to relate the condition of the corticospinal system with the voluntary control of lower-limb muscles in persons with motor-incomplete spinal cord injury. It consisted of two phases. In a group of ten healthy subjects, single and paired transcranial magnetic stimulation (T...

journal_title：Experimental brain research

authors： McKay WB,Lee DC,Lim HK,Holmes SA,Sherwood AM

更新日期：2005-06-01 00:00:00

abstract：:We studied the effects of morphine injected either systemically or into the dorsal periaqueductal gray (DPAG) or nucleus accumbens (NA) using conventional and ethological analyses of behavior of rats submitted to the elevated plus-maze test with transparent walls. Intraperitoneal morphine (0.1 mg/kg and 0.3 mg/kg) inc...

journal_title：Experimental brain research

authors： Anseloni VC,Coimbra NC,Morato S,Brandão ML

更新日期：1999-11-01 00:00:00

abstract：:The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimul...

journal_title：Experimental brain research

authors： Bottini G,Sterzi R,Paulesu E,Vallar G,Cappa SF,Erminio F,Passingham RE,Frith CD,Frackowiak RS

更新日期：1994-01-01 00:00:00

abstract：:Previous studies have shown that rearing rabbits in a stroboscopically illuminated environment results in a decrease in orientation and direction selectivity and an increase in responsivity to stroboscopic stimuli among neurons in area 17. In the present study, the critical period for susceptibility to these effects w...

journal_title：Experimental brain research

authors： Pearson HE,Berman N,Murphy EH

更新日期：1983-01-01 00:00:00

abstract：:The present study analyses the strategies adopted by normal subjects when they are asked to make two separate movements as rapidly as possible one after the other. Five subjects performed the following sequential movements in their own time. 1) Squeeze an isometric force transducer between fingers and thumb to a force...

journal_title：Experimental brain research

authors： Benecke R,Rothwell JC,Day BL,Dick JP,Marsden CD

更新日期：1986-01-01 00:00:00

abstract：:The horizontal and vertical components of the positions of both eyes of rhesus monkeys were measured during periods of binocularly stable eye positions (eye pauses) while the animals fixated a small target. Differences between monocular and binocular viewing, as well as effects of target size and background illuminati...

journal_title：Experimental brain research

authors： Motter BC,Poggio GF

更新日期：1984-01-01 00:00:00