Antimicrobial actions of reactive oxygen species.

abstract：UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...

journal_title：mBio

authors： Aylward FO,Suen G,Biedermann PH,Adams AS,Scott JJ,Malfatti SA,Glavina del Rio T,Tringe SG,Poulsen M,Raffa KF,Klepzig KD,Currie CR

更新日期：2014-11-18 00:00:00

abstract：:Arthritogenic alphaviruses such as Ross River and Chikungunya viruses cause debilitating muscle and joint pain and pose significant challenges in the light of recent outbreaks. How host immune responses are orchestrated after alphaviral infections and lead to musculoskeletal inflammation remains poorly understood. Her...

journal_title：mBio

authors： Zaid A,Tharmarajah K,Mostafavi H,Freitas JR,Sheng KC,Foo SS,Chen W,Vider J,Liu X,West NP,Herrero LJ,Taylor A,Mackay LK,Getts DR,King NJC,Mahalingam S

更新日期：2020-03-03 00:00:00

abstract：UNLABELLED:This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10(4) to 10(6) cel...

journal_title：mBio

authors： Van Trump JI,Wrighton KC,Thrash JC,Weber KA,Andersen GL,Coates JD

更新日期：2011-07-12 00:00:00

abstract：:The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...

journal_title：mBio

authors： Ausiello CM,Cassone A

更新日期：2014-06-10 00:00:00

abstract：UNLABELLED:Sensing of and responding to environmental changes are of vital importance for microbial cells. Consequently, bacteria have evolved a plethora of signaling systems that usually sense biochemical cues either via direct ligand binding, thereby acting as "concentration sensors," or by responding to downstream e...

journal_title：mBio

authors： Fritz G,Dintner S,Treichel NS,Radeck J,Gerland U,Mascher T,Gebhard S

更新日期：2015-07-21 00:00:00

abstract：:Ocean viruses are ubiquitous and abundant and play important roles in global biogeochemical cycles by means of their mortality, horizontal gene transfer, and manipulation of host metabolism. However, the obstacles involved in linking viruses to their hosts in a high-throughput manner bottlenecks our ability to underst...

journal_title：mBio

authors： Deng L,Gregory A,Yilmaz S,Poulos BT,Hugenholtz P,Sullivan MB

更新日期：2012-10-30 00:00:00

abstract：:Misincorporation of uracil or spontaneous cytidine deamination is a common mutagenic insult to DNA. Herpesviruses encode a viral uracil-DNA glycosylase (vUNG) and a viral dUTPase (vDUT), each with enzymatic and nonenzymatic functions. However, the coordinated roles of these enzymatic activities in gammaherpesvirus pat...

journal_title：mBio

authors： Dong Q,Smith KR,Oldenburg DG,Shapiro M,Schutt WR,Malik L,Plummer JB,Mu Y,MacCarthy T,White DW,McBride KM,Krug LT

更新日期：2018-10-30 00:00:00

abstract：:Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical fo...

journal_title：mBio

authors： Johnson CJ,Davis JM,Huttenlocher A,Kernien JF,Nett JE

更新日期：2018-08-21 00:00:00

abstract：UNLABELLED:Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since "humanized" mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice defici...

journal_title：mBio

authors： Taube S,Kolawole AO,Höhne M,Wilkinson JE,Handley SA,Perry JW,Thackray LB,Akkina R,Wobus CE

更新日期：2013-07-16 00:00:00

abstract：:An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::in...

journal_title：mBio

authors： Nguyen NP,Linder S,Flitsch SK,Schiel-Bengelsdorf B,Dürre P,Soucaille P

更新日期：2016-10-04 00:00:00

abstract：:Nicotine, a toxic and addictive alkaloid from tobacco, is an environmental pollutant in areas near cigarette production facilities. Over the last decade, our group has studied, in depth, the pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16. However, little is known regarding whole mechanism(s) reg...

journal_title：mBio

authors： Hu H,Wang L,Wang W,Wu G,Tao F,Xu P,Deng Z,Tang H

更新日期：2019-06-04 00:00:00

abstract：:Biofilm-associated polymicrobial infections, particularly those involving fungi and bacteria, are responsible for significant morbidity and mortality and tend to be challenging to treat. Candida albicans and Staphylococcus aureus specifically are considered leading opportunistic fungal and bacterial pathogens, respect...

journal_title：mBio

authors： Kong EF,Tsui C,Kucharíková S,Andes D,Van Dijck P,Jabra-Rizk MA

更新日期：2016-10-11 00:00:00

abstract：:Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to...

journal_title：mBio

authors： Chaguza C,Andam CP,Harris SR,Cornick JE,Yang M,Bricio-Moreno L,Kamng'ona AW,Parkhill J,French N,Heyderman RS,Kadioglu A,Everett DB,Bentley SD,Hanage WP

更新日期：2016-09-27 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:We have previously identified Vibrio cholerae mutants in which the stress response to subinhibitory concentrations of aminoglycoside is altered. One gene identified, VC1636, encodes a putative DNA/RNA helicase, recently named RadD in Escherichia coli Here we combined extensive genetic characterization and high-through...

journal_title：mBio

authors： Negro V,Krin E,Aguilar Pierlé S,Chaze T,Giai Gianetto Q,Kennedy SP,Matondo M,Mazel D,Baharoglu Z

更新日期：2019-07-02 00:00:00

abstract：UNLABELLED:Despite long-term investment, influenza continues to be a significant worldwide problem. The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a hemagglutination inhibition (HAI) titer of ≥1:40 as the primary correlate of protection. However, recent poor vaccine performance ...

journal_title：mBio

authors： Memoli MJ,Shaw PA,Han A,Czajkowski L,Reed S,Athota R,Bristol T,Fargis S,Risos K,Powers JH,Davey RT Jr,Taubenberger JK

更新日期：2016-04-19 00:00:00

abstract：UNLABELLED:The world is at the precipice of a postantibiotic era in which medical procedures and minor injuries can result in bacterial infections that are no longer effectively treated by antibiotics. Cathelicidins are peptides produced by animals to combat bacterial infections and to regulate innate immune responses....

journal_title：mBio

authors： Kao C,Lin X,Yi G,Zhang Y,Rowe-Magnus DA,Bush K

更新日期：2016-09-20 00:00:00

abstract：UNLABELLED:Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However,...

journal_title：mBio

authors： Nguyen Y,Nguyen NX,Rogers JL,Liao J,MacMillan JB,Jiang Y,Sperandio V

更新日期：2015-03-31 00:00:00

abstract：:Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...

journal_title：mBio

authors： Naas AE,Mackenzie AK,Mravec J,Schückel J,Willats WG,Eijsink VG,Pope PB

更新日期：2014-08-05 00:00:00

abstract：:The effectiveness of influenza vaccines against circulating A(H1N1)pdm09 viruses was modest for several seasons despite the absence of antigenic drift of hemagglutinin (HA), the primary vaccine component. Since antibodies against HA and neuraminidase (NA) contribute independently to protection against disease, antigen...

journal_title：mBio

authors： Gao J,Couzens L,Burke DF,Wan H,Wilson P,Memoli MJ,Xu X,Harvey R,Wrammert J,Ahmed R,Taubenberger JK,Smith DJ,Fouchier RAM,Eichelberger MC

更新日期：2019-04-09 00:00:00

abstract：UNLABELLED:Clathrin-mediated endocytosis (CME) is conserved among eukaryotes and has been extensively analyzed at a molecular level. Here, we present an analysis of CME in the human fungal pathogen Candida albicans that shows the same modular structure as those in other fungi and mammalian cells. Intriguingly, C. albic...

journal_title：mBio

authors： Epp E,Nazarova E,Regan H,Douglas LM,Konopka JB,Vogel J,Whiteway M

更新日期：2013-08-27 00:00:00

abstract：:Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), also known as A20, is a ubiquitin-editing enzyme capable of ubiquitination or deubiquitination of its target proteins. In this study, we show that hepatitis C virus (HCV) infection could induce the expression of A20 via the activation of the A20 promoter. The in...

journal_title：mBio

authors： Lee J,Chan ST,Kim JY,Ou JJ

更新日期：2019-07-23 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：UNLABELLED:Similar to many eukaryotic viruses (and unlike bacteriophages), viruses infecting archaea are often encased in lipid-containing envelopes. However, the mechanisms of their morphogenesis and egress remain unexplored. Here, we used dual-axis electron tomography (ET) to characterize the morphogenesis of Sulfolo...

journal_title：mBio

authors： Quemin ER,Chlanda P,Sachse M,Forterre P,Prangishvili D,Krupovic M

更新日期：2016-09-13 00:00:00

abstract：:The growing ubiquity of electronic devices is increasingly consuming substantial energy and rare resources for materials fabrication, as well as creating expansive volumes of toxic waste. This is not sustainable. Electronic biological materials (e-biologics) that are produced with microbes, or designed with microbial ...

journal_title：mBio

authors： Lovley DR

更新日期：2017-06-27 00:00:00

abstract：:Unlike all other archaeal lineages, ammonia-oxidizing archaea (AOA) of the phylum Thaumarchaeota are widespread and abundant in all moderate and oxic environments on Earth. The evolutionary adaptations that led to such unprecedented ecological success of a microbial clade characterized by highly conserved energy and c...

journal_title：mBio

authors： Abby SS,Kerou M,Schleper C

更新日期：2020-10-13 00:00:00

abstract：:Bacteria of the phylum Bacteroidetes, including commensal organisms and opportunistic pathogens, harbor abundant surface-exposed multiprotein membrane complexes (Sus-like systems) involved in carbohydrate acquisition. These complexes have been mostly linked to commensalism, and in some instances, they have also been s...

journal_title：mBio

authors： Lauber F,Cornelis GR,Renzi F

更新日期：2016-10-25 00:00:00

abstract：:In celebrating the 125th anniversary of the National Institutes of Health (NIH) in August 2012, NIH has been examining its origins, its history, and the visionary men and women whose research have contributed to the saving and/or improving the quality of life of millions of people throughout the world. This minireview...

journal_title：mBio

authors： Morens DM,Fauci AS

更新日期：2012-06-26 00:00:00

abstract：UNLABELLED:Small colony variants (SCVs) are naturally occurring subpopulations of bacteria. The clinical characteristics and treatment outcomes of patients with prosthetic joint infection (PJI) caused by staphylococcal SCVs are unknown. This study was a retrospective series of 113 patients with staphylococcal PJI, with...

journal_title：mBio

authors： Tande AJ,Osmon DR,Greenwood-Quaintance KE,Mabry TM,Hanssen AD,Patel R

更新日期：2014-09-30 00:00:00

abstract：:Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes blinding trachoma and sexually transmitted disease afflicting hundreds of millions of people globally. A fundamental but poorly understood pathophysiological characteristic of chlamydial infection is the propensity to cause persistent in...

journal_title：mBio

authors： Yang C,Kari L,Lei L,Carlson JH,Ma L,Couch CE,Whitmire WM,Bock K,Moore I,Bonner C,McClarty G,Caldwell HD

更新日期：2020-08-18 00:00:00