Abstract：
:Mucocutaneous bleeding is common in childhood and may be the result of primary hemostatic disorders such as vascular abnormalities, von Willebrand disease, thrombocytopenia, and platelet dysfunction. A detailed bleeding history and physical examination are essential to distinguish between normal and abnormal bleeding and to decide whether it is necessary to perform further laboratory evaluation. Initial laboratory tests include complete blood count, peripheral blood smear, mean platelet volume, von Willebrand factor (VWF) antigen assay, VWF ristocetin cofactor activity, and factor VIII activity. Once thrombocytopenia and von Willebrand disease have been excluded, platelet function should be tested by platelet aggregation. Additional specific diagnostic tests, such as platelet secretion tests and flow cytometry for the detection of platelet surface glycoprotein expression, are needed to confirm the raised hypothesis.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
van Ommen CH,Peters Mdoi
10.1007/s00431-011-1532-4subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1-10issue
1eissn
0340-6199issn
1432-1076journal_volume
171pub_type
杂志文章,评审abstract：UNLABELLED:We report on a 5-year-old girl with an unusually severe course of tick-borne encephalitis following passive immunization with specific hyperimmune globulin after a tick bite in an endemic area. Serial investigations of the CSF revealed intrathecal production of specific antibodies paralleled by increasing nu...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02002905
更新日期：1996-09-01 00:00:00
abstract：UNLABELLED:The use of cannabis as both a therapeutic agent and recreational drug is common, and its availability is increasing as a result of legalization in many countries. Among older children, the manifestations of cannabis intoxication are numerous and include both neurological and systemic manifestations that are ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-015-2639-9
更新日期：2016-03-01 00:00:00
abstract：INTRODUCTION:This randomised, observer-blind clinical trial conducted in Turkey evaluated the immunogenicity, safety and interchangeability of three paediatric inactivated hepatitis A vaccines in 424 seronegative children between 1 and 15 years of age. METHODS:Potential subjects were screened for anti-hepatitis A viru...
journal_title：European journal of pediatrics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00431-007-0432-0
更新日期：2007-06-01 00:00:00
abstract：:A 7-year-old boy developed acute, severe hypercalcaemia following the partial excision of a cerebellar medulloblastoma. The serum calcium level was extremely high (19.8 mg/100 ml), but a skeletal survey revealed no apparent bone metastatic lesions; such lesions were only detected by X-ray 3 weeks after the onset of hy...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00444958
更新日期：1987-07-01 00:00:00
abstract：UNLABELLED:The objective of this study was to study the experiences of parents of preterm infants who use social networking sites and the potential of such sites for gathering information and facilitating personal exchange. An anonymous self-reporting questionnaire was administered to parents of infants below 1,500 g b...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2067-7
更新日期：2013-12-01 00:00:00
abstract：:Our prior studies of the molecular epidemiology of group A streptococcus (GAS) pharyngitis indicated that the most common emm types associated with pediatric pharyngitis in North America were 12, 1, 28, and 4. We previously reported that the proportions of pediatric pharyngitis due to emm types 12 and 4 decreased with...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0819-6
更新日期：2009-06-01 00:00:00
abstract：:Sera from 33 newborn infants with gestational ages ranging from 27 to 41 weeks were tested by radioimmunoassay for IgG antibodies to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III. Antibody levels to GBS antigens were positively correlated to gestational age and birthweight. However, only the ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00445584
更新日期：1984-06-01 00:00:00
abstract：:Heart rate variability (HRV) is currently considered the most valuable non-invasive test to investigate the autonomic nervous system function, based on the fact that fast fluctuations might specifically reflect changes of sympathetic and vagal activity. An association between abnormal values of HRV and brain impairmen...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-020-03882-3
更新日期：2020-11-27 00:00:00
abstract：UNLABELLED:Chronic lung disease (CLD) is an inflammatory disorder; in patients with other inflammatory disorders exhaled nitric oxide (NO) levels are elevated. The aim of this study was to test the hypothesis that prematurely born infants with CLD would have elevated exhaled NO levels compared to those without CLD and ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-004-1480-3
更新日期：2004-09-01 00:00:00
abstract：:Two children with congenital cytomegalovirus infection and intracerebral echogenicities were investigated by computer sonography and colour Doppler imaging (CDI). By simultaneous imaging of brain tissue and CDI, blood flow within the stripe-like echogenicities of the basal ganglia was demonstrated. Using CDI the echog...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959476
更新日期：1990-11-01 00:00:00
abstract：:A case of trichothiodystrophy (TTD) without photosensitivity is reported in an 8-year-old girl. Electron microscopic (EM) examination of the keratinocytes showed fibrillary bundles in the cytoplasm thinner and less electron dense than those of the normal cells and large membrane-bound vacuoles filled with granular-fil...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00496431
更新日期：1988-05-01 00:00:00
abstract：:GB virus C (GBV-C) is a blood-borne flavivirus. The prevalence of GBV-C viremia among healthy adults is 0.5% to 4% and, to date, no disease has been definitely associated with GBV-C infection. We conducted a cross-sectional study to evaluate GBV-C viremia prevalence in a group of 327 healthy children with normal alani...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-007-0624-7
更新日期：2008-09-01 00:00:00
abstract：:The aim of this study was to assess demographic data, clinical presentation, metabolic features, and treatment in 76 children with urolithiasis presented from 2002 to 2011. Urolithiasis is responsible for 2.5/1,000 pediatric hospitalizations, with new cases diagnosed in 1.1/1,000 admissions. From the observed period, ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-013-2165-6
更新日期：2014-03-01 00:00:00
abstract：:Mitochondrial disorders are a clinically and biochemically diverse group of disorders which may involve multiple organ systems. General anaesthesia (GA) poses a potential risk of decompensation in children with mitochondrial disorders, and there is little guidance for anaesthetists and other clinicians regarding the o...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-016-2813-8
更新日期：2017-01-01 00:00:00
abstract：:Patients suffering from a mitochondrial (encephalo-)myopathy have a remarkable clinical heterogeneity. A reliable and extensive investigation must be performed in order to obtain a correct diagnosis, but many factors may influence the ultimate results of these investigations leading, under certain circumstances, to an...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01956139
更新日期：1993-03-01 00:00:00
abstract：:A combination of humoral immunodeficiency and isolated growth hormone deficiency was observed in a girl with Mulibrey nanism. The humoral immunodeficiency consisted of subnormal concentration of serum IgG, in particular IgG2 and IgG4, and low concentration of serum IgM. Serum IgA and IgD were elevated, IgE was absent....
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01955061
更新日期：1993-06-01 00:00:00
abstract：:Central line-associated bloodstream infection (CLABSI) is a significant cause of morbidity and mortality in neonatal intensive care units (NICUs). A "bundle" is defined as a combination of evidence-based interventions that provided they are followed collectively and reliably, are proven to improve patient outcomes. Th...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-020-03844-9
更新日期：2021-02-01 00:00:00
abstract：:So far, a recognizable pattern of clinical symptoms for child sexual abuse (CSA), especially in young male children, is lacking. To improve early recognition of CSA, we reviewed physical complaints, physical examination, and tests on sexually transmitted infections (STIs) in confirmed victims (predominantly preschool ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-017-2996-7
更新日期：2017-10-01 00:00:00
abstract：:This article summarizes some research on the development of motion perception in early infancy. The sensitivity for slow and rapid motion was studied with 1-month-old and 3-month-old babies. The findings suggest that there are different developmental courses for the detection of slow and rapid motion. The ability to d...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02191506
更新日期：1995-01-01 00:00:00
abstract：:The involvement of minors in clinical research is inevitable to catch up with the lack of drugs labeled for pediatric use. To encourage the responsible conduct of pediatric clinical trials in the EU, an extensive legal framework has been developed over the past decade in which the practical, ethical, legal, social, an...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0915-7
更新日期：2009-10-01 00:00:00
abstract：:The correlation between the appearance of functionally-atypical factor VII and perinatal complications was investigated in 66 newborn infants. The presence of an abnormal clotting factor was assumed if the ratio between clotting activity and antigen-related factor VII material exceeded the normal range for adult plasm...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00493570
更新日期：1977-08-12 00:00:00
abstract：:The internet is an integral tool for information, communication, and entertainment among adolescents. As adolescents devote increasing amounts of time to utilizing the internet, the risk for adopting excessive and pathological internet use is inherent. The study objectives include assessing the characteristics and pre...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-008-0811-1
更新日期：2009-06-01 00:00:00
abstract：:From time to time, paediatricians are confronted with children who might suffer from a primary immunodeficiency disease. For practical purposes, these children can be divided into four main clinical categories: (1) a relatively large group of children with recurrent ear-nose and throat and lower respiratory tract infe...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s004310100797
更新日期：2001-10-01 00:00:00
abstract：UNLABELLED:Click-evoked oto-acoustic emissions (CEOAE) are acoustic responses produced by the inner ear, reflecting functional auditory integrity. We studied both the success rate of the CEOAE method and the CEOAE presence in preterm infants during their stay at the Neonatal Intensive Care Unit (NICU), by analysis of t...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s004310050986
更新日期：1998-12-01 00:00:00
abstract：:Homeopathic globules are frequently used in children as a first-line treatment. Most of these globules are coated with sugar substitutes like xylitol; these substitutes are known for their laxative effect. Our patient shows that consumption of globules coated with xylitol does not have only laxative effects. It may ca...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-010-1249-9
更新日期：2010-12-01 00:00:00
abstract：:Data show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and de...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s00431-020-03801-6
更新日期：2020-09-10 00:00:00
abstract：:The results of 24 h oesophageal pH monitoring, performed in 129 infants aged 6-10 weeks, were compared to those in the same patients after shorter periods (3, 6, 9 and 12 h). In the investigated population there was no significant difference between the reflux index (percentage of time with a pH < 4.0) after 12 or 24 ...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF01959212
更新日期：1994-02-01 00:00:00
abstract：:Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150 μg because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens wer...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s00431-019-03391-y
更新日期：2019-07-01 00:00:00
abstract：:A patient with a cerebro-hepato-renal syndrome was investigated. The visceral manifestations were those of the Zellweger syndrome (ZS); however, the child exhibited muscular hypertonia and survived into the 2nd year of life. Ultramicroscopically, hepatocytes were lacking peroxisomes, but, contrary to findings in one p...
journal_title：European journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF00441934
更新日期：1977-03-18 00:00:00
abstract：:A 13-year-old boy with a 46,XY,r(7) karyotype presented with growth failure, microcephaly, achromic spots and multiple pigmented naevi. Psychomotor development was normal and no major malformations were present. Comparison with four previously reported patients with ring chromosome 7 shows that the most frequent findi...
journal_title：European journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF01959398
更新日期：1990-04-01 00:00:00
