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The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children.

Abstract：

:GB virus C (GBV-C) is a blood-borne flavivirus. The prevalence of GBV-C viremia among healthy adults is 0.5% to 4% and, to date, no disease has been definitely associated with GBV-C infection. We conducted a cross-sectional study to evaluate GBV-C viremia prevalence in a group of 327 healthy children with normal alanine amino transferase (ALT) levels (Group A) and elevated ALT levels (Group B) of unknown origin, and among 38 pediatric patients with mother-to-child-transmitted hepatitis C virus (HCV) infection (Group C). No statistically significant differences were observed between prevalences in Groups A and B (2.2% vs 6.7%, p = 0.06). None of the children in Groups A or B who tested positive for GBV-C RNA showed any clinical symptoms. The prevalence of GBV-C viremia in Group A was lower than for patients in Group C (2.2% vs 13.2%, p = 0.007); no differences were observed in HCV infection characteristics between those patients who were co-infected with GBV-C and those who were not. In conclusion, while GBV-C viremia is more frequent among HCV-infected pediatric patients, it is neither associated with liver disease nor has any influence on HCV-related chronic hepatitis.

journal_name

Eur J Pediatr

journal_title

European journal of pediatrics

authors

Claret G,Noguera A,González-Cuevas A,García-García JJ,Fortuny C,Muñoz-Almagro C

doi

10.1007/s00431-007-0624-7

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

991-4

issue

9

eissn

0340-6199

issn

1432-1076

journal_volume

167

pub_type

杂志文章

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