Abstract：
BACKGROUND:The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q(aw)) in a group of heart failure (HF) and control subjects. METHODS:Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF=27±6%, age=65±9 yr) and 12 age- and sex-matched controls (CTRL: LVEF=60±7%, age=62±8 yr). Measures of Q˙(aw) (soluble gas method) and PF were collected upright and following 30min in the supine position. RESULTS:Q˙(aw) was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75% (FEF(25-75)) and FEF 75% (FEF75) with the supine position were observed in the HF group only. Changes in Q˙(aw) were related to changes in PF only in the HF patient groups (ΔFVC, % predicted, r = -0.45, p<0.04, ΔFEV1 r = -0.61, p<0.01, ΔFEV1% predicted, r = -0.45, p<0.04). CONCLUSION:These data demonstrate that relationships between postural changes in Q˙(aw) and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Ceridon ML,Morris NR,Olson TP,Lalande S,Johnson BDdoi
10.1016/j.resp.2011.06.021subject
Has Abstractpub_date
2011-09-15 00:00:00pages
269-74issue
2eissn
1569-9048issn
1878-1519pii
S1569-9048(11)00234-5journal_volume
178pub_type
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