Abstract：
:Embolus occlusion of pulmonary arteries can result in elevated pulmonary blood pressures, often resulting in pulmonary hypertension (PH). Experimental observations have shown that small emboli (diameter <170 μm) can have a disproportionate effect on pulmonary vascular resistance (PVR) compared with larger emboli for the same tissue occlusion. We present an anatomically based theoretical model of perfusion in the acinar blood vessels designed to investigate changes in PVR following occlusion of arteries <500 μm in diameter. The model predicts that emboli lodged near proximal capillary beds have a greater effect on PVR--regardless of their size--than emboli occluding 200 μm diameter arterioles, with PH occurring for 10% less tissue occlusion. Capillary blood pressures are predicted to exceed 24 mmHg (levels initiating capillary wall damage) in regions of the capillary bed at approximately the onset of PH. This study focuses on the effect of mechanical obstruction alone; however, we present simple models of vasoconstriction illustrating an increased impact on PVR.
journal_name
Respir Physiol Neurobioljournal_title
Respiratory physiology & neurobiologyauthors
Clark AR,Burrowes KS,Tawhai MHdoi
10.1016/j.resp.2010.12.018subject
Has Abstractpub_date
2011-03-15 00:00:00pages
365-74issue
3eissn
1569-9048issn
1878-1519pii
S1569-9048(10)00460-Xjournal_volume
175pub_type
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