Abstract:
BACKGROUND:Interfacing an amputee's upper-extremity stump nerves to control a robotic hand requires training of the individual and algorithms to process interactions between cortical and peripheral signals. OBJECTIVE:To evaluate for the first time whether EEG-driven analysis of peripheral neural signals as an amputee practices could improve the classification of motor commands. METHODS:Four thin-film longitudinal intrafascicular electrodes (tf-LIFEs-4) were implanted in the median and ulnar nerves of the stump in the distal upper arm for 4 weeks. Artificial intelligence classifiers were implemented to analyze LIFE signals recorded while the participant tried to perform 3 different hand and finger movements as pictures representing these tasks were randomly presented on a screen. In the final week, the participant was trained to perform the same movements with a robotic hand prosthesis through modulation of tf-LIFE-4 signals. To improve the classification performance, an event-related desynchronization/synchronization (ERD/ERS) procedure was applied to EEG data to identify the exact timing of each motor command. RESULTS:Real-time control of neural (motor) output was achieved by the participant. By focusing electroneurographic (ENG) signal analysis in an EEG-driven time window, movement classification performance improved. After training, the participant regained normal modulation of background rhythms for movement preparation (α/β band desynchronization) in the sensorimotor area contralateral to the missing limb. Moreover, coherence analysis found a restored α band synchronization of Rolandic area with frontal and parietal ipsilateral regions, similar to that observed in the opposite hemisphere for movement of the intact hand. Of note, phantom limb pain (PLP) resolved for several months. CONCLUSIONS:Combining information from both cortical (EEG) and stump nerve (ENG) signals improved the classification performance compared with tf-LIFE signals processing alone; training led to cortical reorganization and mitigation of PLP.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Tombini M,Rigosa J,Zappasodi F,Porcaro C,Citi L,Carpaneto J,Rossini PM,Micera Sdoi
10.1177/1545968311408919subject
Has Abstractpub_date
2012-03-01 00:00:00pages
275-81issue
3eissn
1545-9683issn
1552-6844pii
1545968311408919journal_volume
26pub_type
杂志文章abstract:BACKGROUND:There is growing interest in the use of D-amphetamine (D-AMPH) as a pharmacological treatment to supplement rehabilitative therapy following stroke. Based on the success of earlier animal models, several clinical studies have demonstrated beneficial effects of applying physical rehabilitation while stroke pa...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968306290773
更新日期:2006-12-01 00:00:00
abstract::The Motor Status Scale (MSS) measures shoulder, elbow (maximum score = 40), wrist, hand, and finger movements (maximum score = 42), and expands the measurement of upper extremity impairment and disability provided by the Fugl-Meyer (FM) score. This work examines the interrater reliability and criterion validity of the...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/154596830201600306
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Stroke survivors can exhibit abnormally elevated oxygen consumption during walking. Therapeutic interventions can improve gait deficits and oxygen consumption. A practical measure of oxygen cost is not available. This study tested the usefulness of an indirect index of oxygen cost, the Physiological Cost Ind...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307300400
更新日期:2007-09-01 00:00:00
abstract::Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery. ...
journal_title:Neurorehabilitation and neural repair
pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive moto...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
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abstract:BACKGROUND:Predicting walking outcomes poststroke is a challenge for clinicians. OBJECTIVE:To identify the extent to which exercise dose (repetitions of leg movements) in the first week of a comprehensive stroke unit stay predicts discharge mobility. METHODS:A cohort study was conducted on 200 consecutive people admi...
journal_title:Neurorehabilitation and neural repair
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doi:10.1177/1545968312439628
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abstract:BACKGROUND:Fatigue is a debilitating symptom in multiple sclerosis (MS). Previous studies showed no association between fatigue as perceived by the patient and physiological measures of fatigability. OBJECTIVE:The authors investigated associations between perceived fatigue and measures of fatigability after correction...
journal_title:Neurorehabilitation and neural repair
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doi:10.1177/1545968311416991
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journal_title:Neurorehabilitation and neural repair
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abstract:BACKGROUND:Physical rehabilitation programs can lead to improvements in mobility in people with multiple sclerosis (PwMS). OBJECTIVE:To identify which rehabilitation program elements are employed in real life and how they might affect mobility improvement in PwMS. METHODS:Participants were divided into improved and n...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND AND PURPOSE:Poststroke functional outcome and discharge disposition are influenced by age, lesion location and size, severity of neurological insult, prior functional ability, and social support. The effect of admission ambulation velocity on length of stay and discharge disposition has not been previously r...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Surface electrical stimulation of the abdominal muscles, with electrodes placed in the posterolateral position, combined with a voluntary cough can assist clearance of airway secretions in individuals with high-level spinal cord injury (SCI). OBJECTIVE:To determine whether an increase in stimulus intensity ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314552527
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journal_title:Neurorehabilitation and neural repair
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abstract:BACKGROUND:A randomized clinical has shown the effectiveness of intramuscular electrical stimulation for the treatment of poststroke shoulder pain. OBJECTIVE:Identify predictors of treatment success and assess the impact of the strongest predictor on outcomes. METHOD:This is a secondary analysis of a multisite random...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Neurorehabilitation and neural repair
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journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
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更新日期:2013-02-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
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doi:10.1177/1545968309360417
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abstract:BACKGROUND:Functional neuroimaging studies show adaptive changes in areas adjacent and distant from the stroke. This longitudinal study assessed whether changes in cortical excitability in affected and unaffected motor areas after acute stroke correlates with functional and motor recovery. METHODS:We studied 13 patien...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307313505
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Recovery from stroke is often said to have "plateaued" after 6 to 12 months. Yet training can still improve performance even in the chronic phase. Here we investigate the biomechanics of accuracy improvements during a reaching task and test whether they are affected by the speed at which movements are practi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
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journal_title:Neurorehabilitation and neural repair
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journal_title:Neurorehabilitation and neural repair
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更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated the efficacy of functional electrical stimulation in the management of foot drop after stroke. OBJECTIVE:To compare changes in walking performance with the WalkAide (WA) foot-drop stimulator and a conventional ankle-foot orthosis (AFO). METHODS:Individuals with stroke within the p...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2013-09-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309332878
更新日期:2009-09-01 00:00:00
abstract::Background. Understanding the factors that influence language recovery in aphasia is important for improving prognosis and treatment. Chronic comprehension impairments in Wernicke's aphasia (WA) are associated with impairments in auditory and phonological processing, compounded by semantic and executive difficulties. ...
journal_title:Neurorehabilitation and neural repair
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更新日期:2019-10-01 00:00:00
abstract::Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for ...
journal_title:Neurorehabilitation and neural repair
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abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...
journal_title:Neurorehabilitation and neural repair
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更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Ambulating on stairs is an important aspect of daily activities for many individuals with incomplete spinal cord injury (SCI), and little is known about the effect of training for this specific task. OBJECTIVE:The goal of this study was to determine whether staircase ascent training enhances motor recovery ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310378510
更新日期:2011-01-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
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