Abstract：
INTRODUCTION:Sleep disordered breathing (SDB), cardiovascular disease (CVD) and impaired cardiac function are common in elderly people. We investigated the association of SDB and mortality in a community dwelling elderly population, considering CVD and objectively measured impaired cardiac function have been poorly studied thus far. AIM:To investigate whether SDB is a factor that affects mortality in elderly people, with a focus on those with CVD and/or signs of impaired cardiac function. METHODS:A prospective cohort design was used and 331 community dwelling elderly aged 71-87 years underwent one-night polygraphic recordings in the subjects' homes. CVD and systolic function were objectively established. Mortality data were collected after 6 years. RESULTS:In the total population there were no significant associations between mortality and SDB. In those with CVD and impaired systolic function, as measured by NT-proBNP, oxygen desaturation index (ODI) ≥10 was associated with mortality. The hazard ratio of 3.0 (CI 95% 1.1-8.6, p=0.03) remained statistically significant after adjustments for age, gender, diabetes and plasma values of NT-proBNP. CONCLUSION:SDB in community dwelling elderly has no overall association to mortality irrespective of degree of SDB. However, hypoxic events (i.e., ODI ≥10) were associated with mortality in the group who had CVD in combination with impaired systolic function.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Johansson P,Alehagen U,Ulander M,Svanborg E,Dahlström U,Broström Adoi
10.1016/j.sleep.2011.03.012subject
Has Abstractpub_date
2011-09-01 00:00:00pages
748-53issue
8eissn
1389-9457issn
1878-5506pii
S1389-9457(11)00152-3journal_volume
12pub_type
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