Abstract：
OBJECTIVES:Altered brain iron homeostasis with regional iron deficiency has been previously reported in several studies of restless legs syndrome (RLS) patients. Inconsistencies still exist, however, in the reported iron changes in different brain regions and different RLS phenotypes. The purpose of this study was to assess differences in brain iron concentrations between RLS patients and healthy controls and their relation to severity of disease and periodic limb movement during sleep (PLMS). METHODS:Assessment of brain iron was done using quantitative magnetic susceptibility measurement, which has been shown to correlate well with the tissue iron content in brain's gray matter. Thirty-nine RLS patients and 29 age-matched healthy controls were scanned at 7 T. Magnetic susceptibilities in substantia nigra (SN), thalamus, striatum, and several iron-rich gray matter regions were quantified and compared with related clinical measures. RESULTS:Compared with healthy controls, RLS patients showed significantly decreased magnetic susceptibility in the thalamus and dentate nucleus. No significant difference was found in the SN between RLS patients and healthy controls, but a significant correlation was observed between magnetic susceptibility in SN and the PLMS measure. CONCLUSIONS:Using quantitative magnetic susceptibility as an in vivo indicator of brain iron content, the present study supports the general hypothesis of brain iron deficiency in RLS and indicates its possible link to PLMS.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Li X,Allen RP,Earley CJ,Liu H,Cruz TE,Edden RAE,Barker PB,van Zijl PCMdoi
10.1016/j.sleep.2016.05.001subject
Has Abstractpub_date
2016-06-01 00:00:00pages
75-82eissn
1389-9457issn
1878-5506pii
S1389-9457(16)30047-8journal_volume
22pub_type
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