Abstract：
:Circadian clocks are intracellular molecular mechanisms designed to allow the cell, organ, and organism to prepare for an anticipated stimulus prior to its onset. In order for circadian clocks to maintain their selective advantage, they must be entrained to the environment. Light, sound, temperature, physical activity (including sleep/wake transitions), and food intake are among the strongest environmental factors influencing mammalian circadian clocks. Normal circadian rhythmicities in these environmental factors have become severely disrupted in our modern day society, concomitant with increased incidence of type 2 diabetes mellitus, obesity, and cardiovascular disease. Here, we review our current knowledge regarding the roles of peripheral circadian clocks, concentrating on those found within tissues directly involved in metabolic homeostasis and cardiovascular function. We propose that both inter- and intra-organ dyssynchronization, through alteration/impairment of peripheral circadian clocks, accelerates the development of cardiovascular disease risk factors associated with cardiometabolic syndrome.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Young ME,Bray MSdoi
10.1016/j.sleep.2006.12.010subject
Has Abstractpub_date
2007-09-01 00:00:00pages
656-67issue
6eissn
1389-9457issn
1878-5506pii
S1389-9457(07)00039-1journal_volume
8pub_type
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