Abstract:
OBJECTIVE:To report our findings from a sample of narcoleptic children and adolescents evaluated in our unit from 1988 to 2005. PATIENTS AND METHODS:The sample was composed of nine children (5 boys) with a mean age of 14.5 years at diagnosis. The protocol included the following: Epworth, Ullanlinna narcolepsy scale, and Stanford cataplexy questionnaires; physical, psychological and neurological examinations; neuroimaging; PSG+MSLT recordings; HLA and in two cases Hcrt-1 level in CSF. RESULTS:Narcolepsy was sporadic in all cases. The first symptom was EDS with a mean age at onset of 9.4±2.5 years (range 6-13 years). All patients complained of cataplexy. Other symptoms were hypnagogic hallucinations (4 children) and sleep paralysis (3 children). All the children performed poorly at school, 4 had emotional disorders with depression, 4 displayed nocturnal eating and weight gain. Mean BMI was 25.0 kg/m(2). One girl was diagnosed as having precocious puberty, polycystic ovary syndrome (PCOS), hyperandrogenism and insulin resistance. The MRI showed a partial empty sella. Hcrt-1 was undetectable in her CSF. The mean Ullanlinna score was 24.6; PSG showed disturbed nocturnal sleep and the MSLT showed a mean sleep latency of 2.1 min and 3 SOREMPs. Eight children were DR2-DQ1-positive, whereas one boy was DR2-negative but DQ1-positive. In two patients, Hcrt-1 was undetectable. All children, in addition to scheduled naps during the day, were treated with modafinil or methylphenidate combined with an antidepressant and in two cases with sodium oxybate. CONCLUSION:NC was sporadic in all children and associated with precocious puberty and PCOS, hyperandrogenism and insulin resistance in one case. EDS, cataplexy, disturbed nocturnal sleep, nocturnal eating, poor school performance, and emotional disorders were the principal complaints. All patients had DQB1∗0602 and Hcrt-1 was evaluated in two cases (undetectable in both).
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Peraita-Adrados R,García-Peñas JJ,Ruiz-Falcó L,Gutiérrez-Solana L,López-Esteban P,Vicario JL,Miano S,Aparicio-Meix M,Martinez-Sopena MJdoi
10.1016/j.sleep.2010.02.017subject
Has Abstractpub_date
2011-01-01 00:00:00pages
24-7issue
1eissn
1389-9457issn
1878-5506pii
S1389-9457(10)00295-9journal_volume
12pub_type
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