Abstract：
BACKGROUND:It is now recognized that the vast majority of individuals with typical RBD will develop a synucleinopathy; usually 11-16 years after symptom onset. Parasomnia Overlap Disorder (POD) with adolescent-onset dream enactment behavior with phenoconversion to neurodegenerative disease after a long latency has not been previously described. PATIENT:We present a case of a 65-year-old man with presumptive POD who had co-morbid childhood onset sleep walking and adolescent-onset dream enactment behavior beginning at age 17, with subsequent evolution to an increasingly troublesome REM sleep behavior disorder (RBD) at age 64 with Parkinson's Disease (PD) developing a year later. RESULTS:Polysomnography performed at age 64 was consistent with a diagnosis of RBD. Dream enactment behavior preceded PD diagnosis by at least 48 years. Our case represents the youngest reported RBD case who developed PD. CONCLUSIONS:We report the first case of adolescent onset, presumed RBD in the context of presumptive POD developing neurodegenerative disease. Adolescent-onset RBD may have similar prognostic implications as typical RBD, where future phenoconversion to a synucleinopathy is expected.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Xu Z,Oliver JR,Anderson KNdoi
10.1016/j.sleep.2019.01.041subject
Has Abstractpub_date
2019-05-01 00:00:00pages
97-99eissn
1389-9457issn
1878-5506pii
S1389-9457(18)30842-6journal_volume
57pub_type
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