Abstract:
OBJECTIVE:Ramelteon, an MT(1)/MT(2) melatonin receptor agonist, was evaluated for its ability to reduce sleep-onset difficulties associated with eastward jet travel. METHODS:Healthy adults (n=110) with a history of jet lag sleep disturbances were flown eastward across five time zones from Hawaii to the east coast of the US. Ramelteon 1, 4, or 8 mg or placebo was administered 5 min before bedtime (local time) for four nights. Sleep parameters were measured using polysomnography (PSG) on Nights 2, 3, and 4. Next-day residual effects were assessed using psychomotor and memory function tests. RESULTS:Compared to placebo, there was a significant decrease in mean latency to persistent sleep (LPS) on Nights 2-4 with ramelteon 1mg (-10.64 min, P=0.030). No consistent significant differences were observed with ramelteon vs. placebo on measures of next-day residual effects except on Day 4 where participants in all ramelteon groups performed significantly worse on the immediate memory recall test compared with placebo (P < or = 0.05). The incidence of adverse events was similar for ramelteon and placebo. CONCLUSION:After a 5-h phase advance due to eastward jet travel, ramelteon 1mg taken before bedtime for four nights reduced mean LPS relative to placebo in healthy adults.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Zee PC,Wang-Weigand S,Wright KP Jr,Peng X,Roth Tdoi
10.1016/j.sleep.2010.03.010subject
Has Abstractpub_date
2010-06-01 00:00:00pages
525-33issue
6eissn
1389-9457issn
1878-5506pii
S1389-9457(10)00162-0journal_volume
11pub_type
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