当前位置： SCI文献检索 > SLEEP MEDICINE期刊下所有文献 > The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels.

The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels.

Abstract：

OBJECTIVES:The aim of the study was to prospectively examine all patients with a diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and augmentation and their associations, including ferritin levels. METHODS:Patients were stratified into patients with RLS as ancillary diagnosis, RLS sufferers without current augmentation and RLS sufferers with current augmentation. Work-up included RLS severity scales and blood biochemical variables including indices of iron metabolism. RESULTS:In an 18-month period, 302 patients with RLS (183 women, 119 men; mean age, 59.1+/-13.7 years) were recruited. RLS was considered idiopathic in 291 patients (96.4%). Most patients (240, 79.5%) were RLS sufferers, whereas the remaining 62 (20.5%) had RLS as ancillary diagnosis. Nineteen out of 162 patients treated with dopaminergic agents (11.7%) had current augmentation. Almost one-third of all patients (31.1%) had ferritin levels <50microg/l. Patients with an ancillary diagnosis of RLS had higher ferritin levels than RLS sufferers without current augmentation. The lowest ferritin levels were present in RLS sufferers with current augmentation 132.8+/-98.0microg/l vs. 100.6+/-84.5microg/l vs. 55.8+/-43.6microg/l; p=0.002). Patients with augmentation did not differ from non-augmented patients regarding age, gender, RLS etiology, presence of previous augmentation, or any other documented comorbidity (p>0.05). CONCLUSION:The severity spectrum of RLS in this clinical cohort ranged from the ancillary diagnosis of RLS to augmented RLS. There was an inverse correlation between RLS severity and ferritin levels. Patients with current augmentation had the lowest ferritin levels. Our data further strengthen a putative role of low iron stores as a potential aggravator of idiopathic RLS. Moreover, low ferritin might represent a potential biomarker of RLS augmentation under dopaminergic therapy.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Frauscher B,Gschliesser V,Brandauer E,El-Demerdash E,Kaneider M,Rücker L,Poewe W,Högl B

doi

10.1016/j.sleep.2008.09.007

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

611-5

issue

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(08)00272-4

journal_volume

pub_type

杂志文章

在线工具

The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels.