Abstract:
OBJECTIVES:Iron deficiency is considered a putative cause for restless legs syndrome (RLS), a human sensorimotor disorder characterized by a circadian presentation of symptoms during the evening hours that disrupts one's ability to sleep. We sought to evaluate the sleep-wake effects of diet-induced iron deficiency in mice as an animal model of RLS. To this end, we hypothesized that the iron-deprived mice would exhibit a sleep-wake circadian pattern characteristic of the human syndrome: increased wakefulness during the hours immediately preceding the sleep-predominant period. METHODS:Following weaning at post-natal day (PND) 21, C57BL/6J mice were assigned to one of two dietary treatments: iron-deficient (ID, n=7) or iron-adequate (i.e., control, CTL, n=6). At PND 44, the mice were surgically instrumented for polysomnographic (PSG) recording, and data were collected at young adulthood: PNDs 59 and 60. Sleep-wake architecture was characterized for the 12-h light and dark periods and also for six consecutive 4-h blocks comprising a 24-h day. RESULTS:The ID mice showed marked increases in wake time in the 4-h period prior to lights-on; both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep were reduced. In contrast, sleep-wake activity did not differ across the 12-h light period. CONCLUSIONS:Dietary iron deficiency in mice elicited increases in wakefulness during a particular circadian time point that corresponds to the period during which RLS symptoms would maximally disturb sleep onset and progression in humans. These data indicate that iron-deficient mice may provide a potentially useful animal model for RLS.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Dean T Jr,Allen RP,O'Donnell CP,Earley CJdoi
10.1016/j.sleep.2006.07.002subject
Has Abstractpub_date
2006-12-01 00:00:00pages
634-40issue
8eissn
1389-9457issn
1878-5506pii
S1389-9457(06)00223-1journal_volume
7pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract:BACKGROUND AND AIM:Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is associated with glucose dysmetabolism and insulin resistance, therefore the amelioration of breathing disturbances during sleep can allegedly modify the levels of markers of glucose regulation and insulin resistance, such as glycated hemoglobin, fa...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2008.10.004
更新日期:2009-09-01 00:00:00
abstract::The association between sleep-disordered breathing and stroke has been a subject of increased interest and research. Obstructive sleep apnea (OSA) is an important risk factor for stroke incidence and mortality. Moreover, OSA is a common clinical outcome after stroke, directly influencing the patient's recovery. The tr...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2014.12.017
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Sleep contributes to processes of memory, but many questions still remain open. The aim of this study was to test the role of different aspects of sleep for memory performance in a group of patients with chronic non-restorative sleep. METHODS:Forty-two consecutive patients (mean age 40.3 years; 31 women) wit...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2006.11.014
更新日期:2007-08-01 00:00:00
abstract::A 63-year-old right-handed woman developed an alien hand syndrome (AHS) after an acute infarction in the territory of the left anterior cerebral artery. The uncontrolled hand movements were present during the daytime and eventually disturbed sleep. Polysomnography revealed that these motor actions only appeared when t...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00236-8
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To assess the association between sleep duration and physical activity and dietary behaviors among adolescents in a representative sample. METHODS:The analysis was performed using data from the 2015 Ningbo Youth Risk Behavior Survey. Associations between physical activity and dietary behaviors and sleep dura...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.06.024
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study analyzes sawtooth waves (STW), a characteristic feature of rapid eye movement (REM) sleep, in temporal lobe epilepsy patients in order to test the hypothesis of STW dysfunction in this population. METHODS:Polysomnographic records from 16 patients with temporal lobe epilepsy and 11 con...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2005.02.005
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Nocturnal eating behavior is shared by patients affected by a parasomnia, sleep-related eating disorder (SRED), and several eating disorders such as night eating syndrome (NES) and binge-eating disorder (BED); however, the differential clinical features of these patients have been poorly studied, with persist...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2014.12.020
更新日期:2015-06-01 00:00:00
abstract::Angelman syndrome is a neurogenetic condition characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioral phenotype that includes sleep problems. It is caused by lack of expression of the UBE3A gene on the maternal chromosome 15q11-q13. Although part of the diagnostic ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2007.07.001
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances of Japanese children. The current study aimed to present psychometric properties and describe the score distribution of the JSQ-ES. In addition, it examined correlations between the sl...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.07.025
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Insufficient sleep increases pain sensitivity in healthy individuals. Additionally, extending sleep (eg, increasing nocturnal sleep time or adding a mid-day nap) has been shown to restore pain sensitivity to baseline levels in sleep deprived/restricted individuals. Whether sleep extension can reduce pain s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.10.023
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Afternoon napping is a common habit in China. We used data obtained from the Dongfeng-Tongji cohort to examine if duration of habitual afternoon napping was associated with risks for impaired fasting plasma glucose (IFG) and diabetes mellitus (DM) in a Chinese elderly population. METHODS:A total of 27,009 p...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2013.04.015
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To evaluate, both polysomnographically and by subjective scales, the efficacy and safety profile of pramipexole for restless legs syndrome (RLS) via a 3-week, double-blind, placebo-controlled, parallel-group, dose-ranging study. METHODS:At baseline and after 3 weeks, periodic limb movements (PLM) and sleep p...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2008.05.014
更新日期:2009-06-01 00:00:00
abstract::For the past 25 years, the 'alpha-delta NREM sleep abnormality' has been used by some as a defining or legitimizing marker for poorly defined rheumatic diseases such as fibromyalgia and chronic fatigue syndrome. Comprehensive review of the literature reveals no support for such a conclusion. Most studies involve small...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(00)00028-9
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Population-based studies of insomnia among adults residing in communities in developing countries are rare. The objectives of this population-based study were to determine the prevalence and factors associated with insomnia among adults (18 years and over) living in a Brazilian town with 15,000 inhabitants (...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(01)00119-8
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:A social gradient in sleep has been demonstrated across the life span, but previous studies have been cross-sectional and used self-reported socioeconomic status (SES) indicators. Using registry-based data on family income trajectories, the current study examined the association between relative poverty in ch...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.06.005
更新日期:2017-09-01 00:00:00
abstract::At the onset of puberty, students shift their sleep to later hours, but school starts early. It is suggested that evening orientation and early school start times do not go well together. Therefore, the aim of this study was to investigate sleep problems in adolescence, and it was expected that the adolescents' evenin...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.09.022
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate longitudinal relationships between sleep problems and subtypes of anxiety symptoms among adolescent earthquake survivors. METHODS:Participants were 1573 adolescents (male, 45.8%; mean age at baseline 15.01 years, standard deviation (SD) = 1.26) in the Wenchuan Earthquake Adole...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.05.017
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:The accuracy of respiratory polygraphy (RP) is limited because of the absence of electroencephalography (EEG). Pulse wave amplitude (PWA) reduction has been shown to be a marker of autonomic activation during arousal, and may represent a substitute for obstructive respiratory-related cortical arousal (RRCA)....
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.02.027
更新日期:2017-06-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the objective and subjective long-term outcome of maxillomandibular advancement (MMA) in Far-East Asian patients with moderate to severe obstructive sleep apnea (OSA). METHODS:This is a long-term follow-up study to evaluate the treatment outcome of MMA in OSA patients by objective polysomn...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.05.024
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Using transcranial B-mode sonography (TCS), the first morphological marker for restless legs syndrome (RLS), hypoechogenicity of the substantia nigra (SN) has been found. The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to i...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2007.09.001
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Sleep restriction and sleep disorders are common causes of excessive daytime sleepiness (EDS). Medical disorders (MD) can also cause EDS, but previous studies have used non-standardized measures, selected samples, or have examined EDS in singular disorders. This study describes the relative degree of EDS a...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2010.04.010
更新日期:2010-10-01 00:00:00
abstract::Sleep is important for optimal cognitive functioning across the lifespan. Among older adults (≥55 years), self-reported short and long sleep durations have been repeatedly, albeit inconsistently, reported to elevate the risk for poor cognitive function. This meta-analytic review quantitatively summarizes the risk for ...
journal_title:Sleep medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.sleep.2015.08.021
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To explore the gender differences of brain regional homogeneity (ReHo) in healthy subjects during the resting-state, after normal sleep, and after sleep deprivation (SD) using functional magnetic resonance imaging (fMRI) and the ReHo method. METHODS:Sixteen healthy subjects (eight males and eight females) ea...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2011.09.019
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to investigate the impact of sleep on osteoporosis. METHODS:The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.06.029
更新日期:2016-09-01 00:00:00
abstract::We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(99)00016-7
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Although there is a growing interest in the independent effect of snoring on carotid atherosclerosis, few studies have observed the relationship between snoring and change in carotid atherosclerosis prospectively. Therefore, the present study aimed to prospectively examine the association of snoring with subc...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2014.03.009
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:An association between migraine and sleep disturbances in children was reported, yet limited clinical data exist. The current study addresses the clinical presentation, polysomnographic (PSG) characteristics, and comorbid sleep diagnoses of children with migraine referred to the sleep clinic. PATIENTS:A retr...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.04.023
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Functional connectivity (FC) changes can occur prior to structural changes. This study aimed to evaluate data-driven whole-brain FC associated with isolated rapid eye movement sleep behavior disorder (iRBD) using multivariate pattern analysis (MVPA). METHODS:This was a cross-sectional study of 50 polysomnogr...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.12.038
更新日期:2021-01-02 00:00:00
abstract:OBJECTIVES:Previous studies comparing objective sleep measures between patients with Parkinson's disease (PD) and control participants were limited by their small sample size. The purpose of this study was to compare objective sleep measures between large-scale cohorts of PD outpatients and community-based older adults...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.09.010
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate if there is a significant effect of lunar phases on subjective and objective sleep variables in the general population. METHODS:A total of 2125 individuals (51.2% women, age 58.8 ± 11.2 years) participating in a population-based cohort study underwent a complete polys...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2015.08.002
更新日期:2015-11-01 00:00:00