Preliminary results on CSF biomarkers for hypothalamic dysfunction in Kleine-Levin syndrome.

Abstract:

OBJECTIVE:To measure CSF biomarkers of hypothalamic dysfunction in patients with typical Kleine-Levin syndrome (KLS) during symptomatic and asymptomatic periods. PATIENTS/METHODS:Two patients with typical KLS were admitted during symptomatic and asymptomatic periods to a research Sleep Disorders Center. Cerebrospinalfluid (CSF) hypocretin-1, histamine (HA), and its major metabolite tele-methylhistamine (t-MHA) levels were measured in two KLS patients in and out of episode. RESULTS:CSF biomarkers of hypothalamic dysfunction measured in two KLS patients in and out of episode revealed low hypocretin levels (within the narcolepsy-cataplexy range) during a hypersomnia episode in the more severe patient, and a 42% decrease (although within normal range) in the second patient. CSF HA and t-MHA measurements in and out of episode revealed a two-fold in-episode decrease in HA in the more severe patient, with no significant change for the second patient, nor for t-MHA levels. CONCLUSION:We reported reversible changes in CSF hypothalamic biomarkers in a typical patient with KLS that reinforces the hypothesis that in some patients KLS episodes may be caused by recurrent functional alterations of the hypothalamus.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Lopez R,Barateau L,Chenini S,Dauvilliers Y

doi

10.1016/j.sleep.2014.07.022

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

194-6

issue

1

eissn

1389-9457

issn

1878-5506

pii

S1389-9457(14)00423-7

journal_volume

16

pub_type

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