Sarcoidosis and interstitial pulmonary fibrosis; two distinct disorders or two ends of the same spectrum.

Abstract:

PURPOSE OF REVIEW:Pulmonary fibrosis is a reparative response characterized by accumulation of extracellular matrix in the lung parenchyma that may be observed in end-stage sarcoidosis. This article will discuss the recent advancements in the understanding of the pathogenesis of pulmonary fibrosis in sarcoidosis in comparison with idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP). RECENT FINDINGS:A recent study examined clinical, radiographic, and histopathologic findings of end-stage sarcoidosis patients with lung fibrosis who underwent lung transplantation. The authors found many of the patients to have moderate-to-severe interstitial pneumonitis in some cases with UIP considered to be atypical of end-stage sarcoidosis. Furthermore, these patients had diagnosis of sarcoidosis for a shorter time prior to transplant compared with individuals without interstitial pneumonitis (mean 4.8 years vs. 23.3 years). Another study found a promoter polymorphism in prostaglandin-endoperoxide synthase 2 (PTGS2), -765G>C, to be associated with susceptibility and increased risk for pulmonary fibrosis in sarcoidosis in the white population compared with healthy controls. An altered Sp1/Sp3 binding to the -765 region has been proposed as a possible mechanism for reduced PTGS2 expression. SUMMARY:A subset of patients with sarcoidosis that progresses to pulmonary fibrosis may share some similar mechanistic and morphologic aberrations with IPF/UIP. Future studies are needed to examine the significance of chronic interstitial pneumonitits and UIP pattern in fibrotic sarcoidosis as a potential marker for progressive disease, and the roles of PTGS2 polymorphism in various ethnic groups and Sp1/Sp3 binding in other fibrotic lung diseases.

journal_name

Curr Opin Pulm Med

authors

Shigemitsu H,Azuma A

doi

10.1097/MCP.0b013e3283486d52

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

303-7

issue

5

eissn

1070-5287

issn

1531-6971

journal_volume

17

pub_type

杂志文章,评审
  • Duration of anticoagulants in acute or recurrent venous thromboembolism.

    abstract::While the most recent trend in secondary prophylaxis after venous thromboembolism has been toward a prolonged duration, it has become obvious that individualization according to risk factors is crucial. Subgroup analyses in a long-term follow-up of a previous trial, as well as new trials on patients with idiopathic th...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200007000-00012

    authors: Schulman S

    更新日期:2000-07-01 00:00:00

  • Oral corticosteroid-dependent asthma: current knowledge and future needs.

    abstract:PURPOSE OF REVIEW:To discuss the current use of oral corticosteroids (OCS) as a chronic treatment in patients with severe asthma and as a rescue treatment for patients presenting with acute exacerbations. RECENT FINDINGS:Airways disease is responsible for the bulk of OCS use in the community and considerable OCS-assoc...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000541

    authors: Pavord ID

    更新日期:2019-01-01 00:00:00

  • Thirty-day mortality rate in women with cancer and venous thromboembolism. Findings from the Registro Informatizado de la Enfermedad Trombo Embólica Registry.

    abstract:PURPOSE OF REVIEW:Cancer patients with venous thromboembolism (VTE) are at increased risk of mortality. Estimating the risks for specific causes of death may help to weigh the risks and benefits of different therapeutic strategies in an individual patient. RECENT FINDINGS:In the Registro Informatizado de la Enfermedad...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32835463a4

    authors: Trujillo-Santos J,Monreal M

    更新日期:2012-09-01 00:00:00

  • The Sleep Heart Health Study: a progress report.

    abstract:PURPOSE OF REVIEW:The Sleep Heart Health Study began in 1994 as a prospective cohort study of cardiovascular disease. The results of longitudinal analysis are not yet available, but numerous analyses of cross-sectional data have been published. This review provides an overview of study results so far. RECENT FINDINGS:...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e328312ed61

    authors: Gottlieb DJ

    更新日期:2008-11-01 00:00:00

  • Outpatient treatment of patients with deep-vein thrombosis or pulmonary embolism.

    abstract::There have been a large number of randomized trials comparing standard unfractionated intravenous heparin with low-molecular-weight heparin for the treatment of deep-vein thrombosis, but only two of these have looked at outpatient therapy. There have been only two randomized trials including patients with symptomatic ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200109000-00019

    authors: Wells PS

    更新日期:2001-09-01 00:00:00

  • Asthma outcomes revisited.

    abstract:PURPOSE OF REVIEW:Asthma outcomes constitute the cornerstone of asthma clinical research. Despite their known importance, it has been difficult for researchers to standardize these outcomes in large part because of the heterogeneity of the disease. This review seeks to provide an overview of recent recommendations for ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32835b11f6

    authors: Parulekar AD,Alobaidy A,Hanania NA

    更新日期:2013-01-01 00:00:00

  • Catamenial pneumothorax.

    abstract:PURPOSE OF REVIEW:Although known for several decades, catamenial pneumothorax has been considered until recently as an extremely rare entity. The condition is now more easily recognized and several studies have been published, with somewhat relevant discrepancies with respect to etiologic, epidemiologic, and management...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32833a9fc2

    authors: Alifano M

    更新日期:2010-07-01 00:00:00

  • Pulmonary involvement in microscopic polyangiitis.

    abstract:PURPOSE OF REVIEW:Microscopic polyangiitis is a systemic necrotizing vasculitis that affects small vessels, resulting in a wide spectrum of organ involvement including the kidneys and the lungs. This paper reviews recent insights and observations into the pathogenesis, clinical manifestations, and treatment of pulmonar...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000170520.63874.fb

    authors: Collins CE,Quismorio FP Jr

    更新日期:2005-09-01 00:00:00

  • Adenosine signaling in asthma and chronic obstructive pulmonary disease.

    abstract:PURPOSE OF REVIEW:The chronic lung diseases, asthma and chronic obstructive pulmonary disease, are pulmonary disorders in which persistent inflammation and alterations in lung structure contribute to a progressive loss of lung function. Although the exact type of inflammation and damage in each disease is distinct, the...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000199002.46038.cb

    authors: Mohsenin A,Blackburn MR

    更新日期:2006-01-01 00:00:00

  • Drug-resistant tuberculosis: worldwide trends, problems specific to Eastern Europe and other hotspots, and the threat to developing countries.

    abstract::Although it had been appreciated that high levels of antituberculous drug resistance existed in some regions of the world, the full extent of the problem was not known. A combined initiative by the World Health Organization and the International Union Against Tuberculosis and Lung Disease was launched in 1994 to addre...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200105000-00006

    authors: Willcox PA

    更新日期:2001-05-01 00:00:00

  • Clinical relevance of distal deep vein thrombosis.

    abstract:PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32830460ea

    authors: Righini M,Bounameaux H

    更新日期:2008-09-01 00:00:00

  • Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a long-term benefit?

    abstract:PURPOSE OF REVIEW:The use of inhaled corticosteroids is one of the most controversial issues in COPD pharmacotherapy. Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent lite...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200403000-00005

    authors: Highland KB

    更新日期:2004-03-01 00:00:00

  • Hypothalamic versus neocortical control of sleep.

    abstract:PURPOSE OF REVIEW:Regions of the neocortex most strongly activated during waking exhibit increased sleep intensity during subsequent sleep. The novel concept that aspects of sleep homeostasis are determined locally in the cortex contrasts with the established views that global changes in neocortical activity during sle...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32833eec92

    authors: Szymusiak R

    更新日期:2010-11-01 00:00:00

  • Intrathoracic neoplasms other than bronchogenic carcinoma.

    abstract::Intrathoracic neoplasms other than bronchogenic carcinoma comprise a disparate group of tumors that have in common an anatomic location within the thorax. For the purposes of this review, they are divided into three categories: pulmonary metastases from locations other than the thorax, mediastinal neoplasms, and unusu...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-199707000-00004

    authors: Yoneda KY,Tharratt RS

    更新日期:1997-07-01 00:00:00

  • Viral infections in obstructive airway diseases.

    abstract::The most common syndromes associated with obstructive lung disease are asthma and chronic obstructive pulmonary disease (COPD). Evidence for a viral etiology of asthmatic exacerbations is well known, but evidence for a role for viruses in COPD exacerbation is just emerging. Viruses may cause chronic infection in both ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200303000-00004

    authors: Seemungal TA,Wedzicha JA

    更新日期:2003-03-01 00:00:00

  • Comorbidities of chronic facial pain and obstructive sleep apnea.

    abstract:PURPOSE OF REVIEW:This article explains the high comorbidity of craniofacial pain (chronic face pain, temporomandibular disorders, and primary headaches) with obstructive sleep breathing disorders and obstructive sleep apnea (OSA). It is recommended that physicians treating OSA should be aware of the concurrent chronic...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000325

    authors: Olmos SR

    更新日期:2016-11-01 00:00:00

  • Insights about the economic impact of chronic obstructive pulmonary disease readmissions post implementation of the hospital readmission reduction program.

    abstract:PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) affects over 12 million adults in the United States and is the third leading cause of 30-day readmissions. COPD is costly with almost $50 billion in direct costs annually. Total COPD costs can be up to double the identified direct costs because of comorbid ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000454

    authors: Press VG,Konetzka RT,White SR

    更新日期:2018-03-01 00:00:00

  • Neurotrophins and asthma.

    abstract::The neurotrophins are a family of peptides that promote survival, growth, and differentiation of neurons. Neurotrophins may also influence the function of nonneuronal cell types, including immune cells. The development and maintenance of asthma is thought to involve the nervous system and the immune system, but the ro...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200101000-00001

    authors: Carr MJ,Hunter DD,Undem BJ

    更新日期:2001-01-01 00:00:00

  • Pulmonary hypertension due to interstitial lung disease.

    abstract:PURPOSE OF REVIEW:Pulmonary hypertension has been reported to complicate the course of a number of fibrotic lung diseases, including idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis and nonspecific interstitial pneumonitis. Most commonly, mild elevations in the mean pulmonary artery pressure are seen...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000599

    authors: King CS,Nathan SD

    更新日期:2019-09-01 00:00:00

  • Lung disease and coal mining: what pulmonologists need to know.

    abstract:PURPOSE OF REVIEW:Coal mine workers are at risk for a range of chronic respiratory diseases including coal workers' pneumoconiosis, diffuse dust-related fibrosis, and chronic obstructive pulmonary disease. The purpose of this review is to describe coal mining processes and associated exposures to inform the diagnostic ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000251

    authors: Go LH,Krefft SD,Cohen RA,Rose CS

    更新日期:2016-03-01 00:00:00

  • Practical management problems of stable chronic obstructive pulmonary disease in the elderly.

    abstract:PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is one of the most prevalent and increasing health problems in the elderly on a worldwide scale. The management of COPD in older patients presents practical diagnostic and treatment issues, which are reviewed with reference to the stable stage of the diseas...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000410747.20958.39

    authors: Pistelli R,Ferrara L,Misuraca C,Bustacchini S

    更新日期:2011-12-01 00:00:00

  • Interstitial lung disease in rheumatoid arthritis: recent advances.

    abstract:PURPOSE OF REVIEW:Subsequent to the ATS/ERS consensus classification of idiopathic interstitial pneumonia, non-specific interstitial pneumonia pattern was the dominant pattern in many collagen vascular diseases, which may explain the better prognosis of interstitial pneumonia associated with collagen disease than idiop...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000239552.55326.ee

    authors: Kim DS

    更新日期:2006-09-01 00:00:00

  • Sleep disordered breathing and risk factors for cardiovascular disease.

    abstract::Patients with sleep disordered breathing (SDB) are at increased risk for cardiovascular disease including hypertension, angina, myocardial infarction, and stroke. Neurohumoral and hemodynamic responses to untreated sleep apnea are likely mechanisms that produce functional and structural changes within the cardiovascul...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200211000-00006

    authors: Phillips BG,Somers VK

    更新日期:2002-11-01 00:00:00

  • Current opinions on non-invasive ventilation as a treatment for chronic obstructive pulmonary disease.

    abstract:PURPOSE OF REVIEW:This review examines the current reports, the evidence and the issues surrounding the use of non-invasive ventilation (NIV) for the treatment of chronic obstructive pulmonary disease (COPD) in both the acute and domiciliary setting. RECENT FINDINGS:With the increasing use of NIV, more recent studies ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e3283659e4c

    authors: Ramsay M,Hart N

    更新日期:2013-11-01 00:00:00

  • Is there a role for macrolides in severe asthma?

    abstract:PURPOSE OF REVIEW:Severe asthma is a heterogeneous syndrome, encompassing several distinct clinical phenotypes. Different molecular and cellular pathways or endotypes determine the type of underlying airway inflammation in patients with severe asthma, which can be categorized as eosinophilic asthma (allergic and nonall...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000017

    authors: Brusselle GG,Joos G

    更新日期:2014-01-01 00:00:00

  • The utility of intrapleural instillation of autologous blood for prolonged air leak after lobectomy.

    abstract:PURPOSE OF REVIEW:Air leak after pulmonary lobectomy is a relatively common problem, which when persistent can be a cause of other postoperative morbidity as well as contributing to extended hospitalization. A number of methods have been proposed to prevent and treat air leakage, but none have proved incontrovertibly e...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e3282fcea76

    authors: Ahmed A,Page RD

    更新日期:2008-07-01 00:00:00

  • Fixed-dose versus adjusted-dose low molecular weight heparin for the initial treatment of patients with deep venous thrombosis.

    abstract::Patients with acute deep vein thrombosis (DVT) were treated with a body-weight independent dosage of 2 x 8000 aXa IU low-molecular-weight heparin (LMWH) Certoparin. After the subcutaneous administration of 8000 IU Certoparin, pharmacodynamic parameters did not differ between patients and healthy volunteers, and the AU...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200209000-00007

    authors: Harenberg J

    更新日期:2002-09-01 00:00:00

  • Normal volume and cellular contents of pleural fluid.

    abstract::The pleural space in healthy humans was thought to contain a few milliliters of fluid, based on extrapolation from animal studies. However, because of the obvious technical difficulties in atraumatically retrieving such a small volume of fluid, the exact volume and cellular content of human pleural fluid has not been ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200107000-00002

    authors: Noppen M

    更新日期:2001-07-01 00:00:00

  • Human immunodeficiency virus and respiratory infection.

    abstract::Pulmonary disease remains a major problem for the 33 million individuals who are thought to be infected with human immunodeficiency virus (HIV) worldwide. Respiratory infections are responsible for a large number of the 2 million deaths that occur each year in association with HIV disease. In countries where the major...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200005000-00013

    authors: Ashley EA,Johnson MA,Lipman MC

    更新日期:2000-05-01 00:00:00

  • Dornase alfa (Pulmozyme).

    abstract:PURPOSE OF REVIEW:Dornase alfa (Pulmozyme) is one of the most commonly used medications to treat the lung disease of cystic fibrosis (CF). As other respiratory medications have entered the clinical market, understanding the proper use and indication for dornase alfa is increasingly important. In addition, dornase alfa ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e328358d51f

    authors: Wagener JS,Kupfer O

    更新日期:2012-11-01 00:00:00