Abstract:
:Pif1 family helicases, which are found in nearly all eukaryotes, have important roles in both nuclear and mitochondrial genome maintenance. Recently, the increasing availability of genome sequences has revealed that Pif1 helicases are also widely found in diverse prokaryotes, but it is currently unknown what physiological function(s) prokaryotic Pif1 helicases might perform. This Perspective aims to briefly introduce the reader to the well-studied eukaryotic Pif1 family helicases and speculate on what roles such enzymes may play in bacteria. On the basis of our hypotheses, we predict that Pif1 family helicases are important for resolving common issues that arise during DNA replication, recombination, and repair rather than functioning in a eukaryotic-specific manner.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Bochman ML,Judge CP,Zakian VAdoi
10.1091/mbc.E11-01-0045subject
Has Abstractpub_date
2011-06-15 00:00:00pages
1955-9issue
12eissn
1059-1524issn
1939-4586pii
22/12/1955journal_volume
22pub_type
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