Abstract:
:Adaptins are subunits of adaptor protein (AP) complexes involved in the formation of intracellular transport vesicles and in the selection of cargo for incorporation into the vesicles. In this article, we report the results of a survey for adaptins from sequenced genomes including those of man, mouse, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis elegans, the plant Arabidopsis thaliana, and the yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We find that humans, mice, and Arabidopsis thaliana have four AP complexes (AP-1, AP-2, AP-3, and AP-4), whereas D. melanogaster, C. elegans, S. cerevisiae, and S. pombe have only three (AP-1, AP-2, and AP-3). Additional diversification of AP complexes arises from the existence of adaptin isoforms encoded by distinct genes or resulting from alternative splicing of mRNAs. We complete the assignment of adaptins to AP complexes and provide information on the chromosomal localization, exon-intron structure, and pseudogenes for the different adaptins. In addition, we discuss the structural and evolutionary relationships of the adaptins and the genetic analyses of their function. Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Boehm M,Bonifacino JSdoi
10.1091/mbc.12.10.2907keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
2907-20issue
10eissn
1059-1524issn
1939-4586journal_volume
12pub_type
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E14-08-1298
更新日期:2015-01-15 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e07-01-0046
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-15 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e09-05-0389
更新日期:2009-12-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e09-08-0744
更新日期:2010-03-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e02-07-0376
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E14-12-1584
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1091/mbc.e07-05-0461
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pub_type: 杂志文章
doi:10.1091/mbc.e04-02-0116
更新日期:2004-06-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e06-01-0089
更新日期:2006-06-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E11-05-0391
更新日期:2011-10-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E16-09-0628
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E11-11-0928
更新日期:2012-06-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E13-08-0460
更新日期:2014-05-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e03-06-0388
更新日期:2004-01-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E13-12-0754
更新日期:2014-03-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E18-02-0088
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doi:10.1091/mbc.3.6.655
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pub_type: 杂志文章
doi:10.1091/mbc.12.1.155
更新日期:2001-01-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.11.5.1631
更新日期:2000-05-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e08-06-0600
更新日期:2009-05-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.9.5.1209
更新日期:1998-05-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.E16-12-0827
更新日期:2018-02-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
doi:10.1091/mbc.e07-10-1088
更新日期:2008-05-01 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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更新日期:2015-07-15 00:00:00
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00