Seminal plasma reactive oxygen species-antioxidants relationship with varicocele grade.

Abstract:

:This work aimed to assess seminal plasma reactive oxygen species (ROS)-antioxidants relationship with varicocele grade in infertile men with oligoasthenoteratozoospermia (OAT). The study included 89 infertile OAT men with varicocele divided into grade I (n = 22) and grade II (n = 43), grade III (n = 24) and compared with 20 healthy fertile controls. In their seminal plasma, two ROS parameters (malondialdehyde [MDA], hydrogen peroxide [H(2) O(2) ]) and four antioxidants (superoxide dismutase [SOD], catalase [Cat], glutathione peroxidase [GPx], vit.C) were estimated. There was significant increase in seminal MDA, H(2) O(2) and significant decrease in seminal SOD, Cat, GPx, vit.C in varicocele-associated OAT cases when compared with the controls. Compared with grade I cases, varicocele cases with grades II, III demonstrated significant increase in estimated seminal MDA, H(2) O(2) and significant decrease in seminal SOD, Cat, GPx, vit.C. It is concluded that seminal oxidative stress (OS) is related to increased varicocele grade in infertile OAT men associated with varicocele.

journal_name

Andrologia

journal_title

Andrologia

authors

Mostafa T,Anis T,El Nashar A,Imam H,Osman I

doi

10.1111/j.1439-0272.2010.01111.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

66-9

issue

1

eissn

0303-4569

issn

1439-0272

journal_volume

44

pub_type

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