Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.

abstract：OBJECTIVE:To investigate the efficacy of the cholesterol absorption inhibitor ezetimibe in patients with refractory familial hyperlipidaemia or intolerant to statin therapy. METHODS:This prospective study assessed the safety and efficacy of ezetimibe in 200 patients with refractory familial hyperlipidaemias not achiev...

journal_title：Current medical research and opinion

authors： Wierzbicki AS,Doherty E,Lumb PJ,Chik G,Crook MA

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:This meta-analysis compared the median overall survival (mOS) of brentuximab vedotin reported in the pivotal phase 2 study with published results of other therapies for the treatment of relapsed/refractory (R/R) Hodgkin lymphoma (HL) post autologous stem cell transplant (ASCT). RESEARCH DESIGN AND METHODS:A ...

journal_title：Current medical research and opinion

authors： Bonthapally V,Yang H,Ayyagari R,Tan RD,Cai S,Wu E,Gautam A,Chi A,Huebner D

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To compare retinal thickness before and after treatment with the fluocinolone acetonide (FAc) 190 µg intravitreal implant in people with diabetic macular edema (DME) using data from the Iluvien Clinical Evidence study in the UK (ICE-UK). METHODS:For this retrospective cohort study, data on people attending ...

journal_title：Current medical research and opinion

authors： Currie CJ,Holden SE,Owens DR

更新日期：2017-10-01 00:00:00

abstract：:Objective: Determine healthcare resource utilization (HCRU) and costs associated with fatigue and stiffness among patients with rheumatoid arthritis (RA).Methods: A retrospective claims analysis compared RA patients with fatigue or stiffness to matched RA control patients with neither. Claims from a large US commercia...

journal_title：Current medical research and opinion

authors： Strand V,Shah R,Atzinger C,Zhou J,Clewell J,Ganguli A,Tundia N

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the efficacy and tolerability of adjunctive lamotrigine differ as a function of whether persons with mental retardation and refractory epilepsy resided in institutions or the community. RESEARCH DESIGN AND METHODS:The analysis was retrospective and employed data from a previously publish...

journal_title：Current medical research and opinion

authors： Sunder TR,McKee JR,Hammer AE,Vuongc A

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To perform an open, non-controlled, multiple-dose, international, multicentre, phase III study to evaluate epoetin zeta, a biosimilar epoetin referenced to epoetin alfa, for the treatment of chemotherapy-induced anaemia in patients with cancer. METHODS:Safety, tolerability and efficacy of subcutaneously admi...

journal_title：Current medical research and opinion

authors： Tzekova V,Mihaylov G,Elezovic I,Koytchev R,Epoetin Zeta Oncology Study Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To determine the ability of statins to prevent the development of new-onset type 2 diabetes mellitus through a meta-analysis of randomized, controlled trials. RESEARCH DESIGN AND METHODS:A systematic literature search through November 6, 2007 was conducted to identify randomized, placebo-controlled trials of...

journal_title：Current medical research and opinion

authors： Coleman CI,Reinhart K,Kluger J,White CM

更新日期：2008-05-01 00:00:00

abstract：:A study was carried out to compare a new, unique chemical strip test for the measurement of urine specific gravity with the traditional methods of hydrometry and refractometry, during water concentration/dilution tests in 12 normal subjects. The pattern of specific gravity results during these serial measurements was ...

journal_title：Current medical research and opinion

authors： Gounden D,Newall RG

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Heart failure (HF) is a major health problem facing the US and studies suggest that the incidence of this condition will rise significantly over the next 10 years. Limiting the incidence or duration of HF hospitalizations would, therefore, have a major impact on healthcare costs. The purpose of this review is...

journal_title：Current medical research and opinion

authors： Williams RE

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Rheumatoid arthritis (RA) is a chronic, debilitating disease affecting an estimated 1.5 million patients in the US. The condition is associated with a substantial health and economic burden. An economic model was developed to evaluate the cost-effectiveness of tofacitinib (a novel oral Janus k...

journal_title：Current medical research and opinion

authors： Claxton L,Taylor M,Gerber RA,Gruben D,Moynagh D,Singh A,Wallenstein GV

更新日期：2018-11-01 00:00:00

abstract：:An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...

journal_title：Current medical research and opinion

authors： Baumgartner H,Schwarz HA,Blum W,Bruhin A,Gallachi G,Goldinger G,Saxer M,Trost H

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Consensus health panels, including the Joint British Societies (JBS), have established increasingly stringent cholesterol goals. However, in clinical settings, most patients do not achieve even the less stringent goals. OBJECTIVE:To provide descriptive data on the proportion of patients in the United Kingdo...

journal_title：Current medical research and opinion

authors： Rajagopalan S,Alemao E,Finch L,Yin D

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:As evidence grows about the management of hyponatremia, a number of different international and national recommendations/guidelines from professional organizations have recently been published that offer guidance on decision-making. However, they include several important differences that cou...

journal_title：Current medical research and opinion

authors： Verbalis JG,Grossman A,Höybye C,Runkle I

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...

journal_title：Current medical research and opinion

authors： Hildemann SK,Barho C,Karmann B,Darius H,Bode C

更新日期：2008-10-01 00:00:00

abstract：:Nine patients with persistently elevated diastolic blood pressure, exceeding 130 mmHg, received an oral dose of labetalol ranging from 200 mg to 400 mg. In all patients, this produced a significant and gradual decline in recumbent systolic and diastolic blood pressure, unaccompanied by symptoms or complications, with ...

journal_title：Current medical research and opinion

authors： Ghose RR,Sampson A

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:A trial was conducted to examine the effects of a timed sequence of hormone supplementation (HS) with oral estradiol (E(2)) and vaginal progesterone (P) following clomiphene citrate (CC) therapy to determine if this regimen can increase pregnancy rates in CC cycles. METHODS:This study was a randomized, open-...

journal_title：Current medical research and opinion

authors： Elkind-Hirsch KE,Darensbourg C,Creasy G,Gipe D

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Poor quality has been reported for some generics and other copies of original products. We performed a pilot study to compare the disintegration/dissolution profiles of FOSAMAX (alendronate) 70 mg tablets with those of copies of FOSAMAX that were manufactured outside the United States. RESEARCH DESIGN AND ME...

journal_title：Current medical research and opinion

authors： Epstein S,Cryer B,Ragi S,Zanchetta JR,Walliser J,Chow J,Johnson MA,Leyes AE

更新日期：2003-01-01 00:00:00

abstract：:A national survey of psychotherapeutic drug use was carried out in the U.S.A. in 1979. Data were obtained from a probability sample (n = 3161) of adults in the general population, using a clinically-oriented interview lasting an average of 90 minutes. The data provide estimates of the prevalence of using anxiolytic an...

journal_title：Current medical research and opinion

authors： Mellinger GD,Balter MB,Uhlenhuth EH

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...

journal_title：Current medical research and opinion

authors： Ram CV

更新日期：2009-01-01 00:00:00

abstract：:Two new benzodiazepines, potassium clorazepate (15 mg. at night), and lorazepam (1 mg. t.d.s.) were compared in 50 patients presenting with anxiety in general practice. The response to treatment was assessed clinically and for patient acceptance. The single-dose regime of potassium clorazepate was significantly better...

journal_title：Current medical research and opinion

authors： Harris PG

更新日期：1974-01-01 00:00:00

abstract：OBJECTIVE:Decision aids (DAs) are increasingly used to operationalize shared decision-making (SDM) but their development is not often described. Decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) involve a trade-off between lowering stroke risk and increasing OAC-associated bleeding risk, and consi...

journal_title：Current medical research and opinion

authors： Kaiser K,Cheng WY,Jensen S,Clayman ML,Thappa A,Schwiep F,Chawla A,Goldberger JJ,Col N,Schein J

更新日期：2015-12-01 00:00:00

abstract：:A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief....

journal_title：Current medical research and opinion

authors： Cardoe N,Steele CE

更新日期：1976-01-01 00:00:00

abstract：:The term "mixed pain" is increasingly applied for specific clinical scenarios, such as low back pain, cancer pain and postsurgical pain, in which there "is a complex overlap of the different known pain types (nociceptive, neuropathic, nociplastic) in any combination, acting simultaneously and/or concurrently to cause ...

journal_title：Current medical research and opinion

authors： Freynhagen R,Rey R,Argoff C

更新日期：2020-12-01 00:00:00

abstract：:A double-blind, placebo-controlled study was carried out in 231 adult patients suffering from acute diffuse pharyngitis or acute tonsillitis with fever and dysphagia to assess the effectiveness of niflumic acid combined with standard antibiotic therapy in relieving pain and inflammation. Patients were allocated at ran...

journal_title：Current medical research and opinion

authors： Sauvage JP,Ditisheim A,Bessede JP,David N

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:Neuropathic pain is often difficult to treat due to a complex pathophysiology. This study evaluated the efficacy, tolerability and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin for neuropathic pain in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneurop...

journal_title：Current medical research and opinion

authors： Baron R,Mayoral V,Leijon G,Binder A,Steigerwald I,Serpell M

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...

journal_title：Current medical research and opinion

authors： Pillai L,Burnett BP,Levy RM,GOAL Study Cooperative Group.

更新日期：2010-05-01 00:00:00

abstract：:In a double-blind study of 102 patients with a mean age of 79 years, zopiclone was compared to flunitrazepam. The patients rated their sleep in a diary. There was no statistically significant difference between the relatively low dose of 5 mg zopiclone and 1 mg flunitrazepam for eleven out of the twelve variables meas...

journal_title：Current medical research and opinion

authors： Dehlin O,Rubin B,Rundgren A

更新日期：1995-01-01 00:00:00

abstract：AIMS:Disease management programs (DMP) for diabetes mellitus (DM) or coronary heart disease (CHD) address the treatment of lipid disorders. The current registry aimed to compare drug utilization, lipid lowering effects and further outcomes of outpatients at high cardiovascular risk in DMP for DM or CHD compared to pati...

journal_title：Current medical research and opinion

authors： Gitt AK,Sonntag F,Jannowitz C,Weizel A,Karmann B,Schaefer JR,Pittrow D,Hildemann SK

更新日期：2016-01-01 00:00:00

abstract：:A study was carried out in 21 patients with Type IIb or Type IV hyperlipoproteinaemia to evaluate the effect of treatment with 600 mg bezafibrate per day over a period of 3 months. The results of the lipid parameters studied showed that there were significant reductions after 1 and 3-months' treatment, respectively, o...

journal_title：Current medical research and opinion

authors： Neuman MP,Kurlat MI,Neuman J

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVES:To compare compliance/persistence, health care resource utilization, and costs associated with single-pill combination (SPC) vs. free-combination (FC) therapies among adult hypertension patients at the national and state level. Combination therapies with angiotensin receptor blocker (ARB) + calcium channel b...

journal_title：Current medical research and opinion

authors： Yang W,Chang J,Kahler KH,Fellers T,Orloff J,Wu EQ,Bensimon AG

更新日期：2010-09-01 00:00:00