EGFR and p53 status of pulmonary pleomorphic carcinoma: implications for EGFR tyrosine kinase inhibitors therapy of an aggressive lung malignancy.

abstract：BACKGROUND:Data on isolated limb perfusion (ILP) in elderly melanoma patients are scarce. We aimed to evaluate the efficacy and safety of ILP in our institutional cohort of melanoma patients. METHODS:We performed retrospective analysis of stage IIIB/C melanoma patients who underwent ILP for melanoma in-transit metasta...

journal_title：Annals of surgical oncology

authors： Madu MF,Deken MM,van der Hage JA,Jóźwiak K,Wouters MWJM,van Akkooi ACJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:We performed a multicenter phase II study on the efficacy and safety of intraoperative radiotherapy (IORT) as partial breast irradiation using multiple devices. METHODS:The primary endpoint was ipsilateral breast tumor recurrence (IBTR). Key inclusion criteria were T < 2.5 cm, age > 50 years, surgical margi...

journal_title：Annals of surgical oncology

authors： Sawaki M,Miyamoto T,Fujisawa T,Itoh Y,Ebara T,Tachibana H,Kodaira T,Kikumori T,Yanagita Y,Iwata H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroid carcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on ove...

journal_title：Annals of surgical oncology

authors： Limberg J,Stefanova D,Ullmann TM,Thiesmeyer JW,Bains S,Beninato T,Zarnegar R,Fahey TJ 3rd,Finnerty BM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:The Ki-67 index is an established prognostic marker for recurrence after resection of pancreatic neuroendocrine tumors (PanNETs) that groups tumors into three categories: low grade (< 3%), intermediate grade (3-20%), and high grade (> 20%). Given that the majority of resected PanNETs have a Ki-67 less than 3...

journal_title：Annals of surgical oncology

authors： Lopez-Aguiar AG,Ethun CG,Postlewait LM,Zhelnin K,Krasinskas A,El-Rayes BF,Russell MC,Sarmiento JM,Kooby DA,Staley CA,Maithel SK,Cardona K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The benefits of hepatic transplantation (HT) compared with hepatic resection (HR) in treating hepatocellular carcinoma (HCC) in patients with cirrhosis are controversial. The aim of this study was to compare the results of these therapeutic options. METHODS:The charts of all patients with cirrhosis who unde...

journal_title：Annals of surgical oncology

authors： Shabahang M,Franceschi D,Yamashiki N,Reddy R,Pappas PA,Aviles K,Flores S,Chaparro A,Levi JU,Sleeman D,Tzakis AG,Kato T,Levi DM,Livingstone AS

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:The peritoneal cancer index (PCI) is used to refer gastrointestinal malignancy patients to either palliative or curative management of their peritoneal carcinomatosis. The aim of this retrospective study was to evaluate the prognostic value of the PCI in patients with primary advanced epithelial ovarian cancer ...

journal_title：Annals of surgical oncology

authors： Gasimli K,Braicu EI,Richter R,Chekerov R,Sehouli J

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The increasing use of mammography has led to a significant increase in the detection of clinically occult lesions, the majority of which prove to be benign. SFNB has been suggested as a means of expediting a diagnosis for lesions that are malignant while limiting surgical biopsies for those that are benign. ...

journal_title：Annals of surgical oncology

authors： Mitnick JS,Vazquez MF,Pressman PI,Harris MN,Roses DF

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Improved survival has been reported for diffuse malignant peritoneal mesothelioma (DMPM) treated by surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). The significance of lymph node involvement in this disease is still poorly understood. METHODS:Prospectively collected clinical da...

journal_title：Annals of surgical oncology

authors： Baratti D,Kusamura S,Cabras AD,Laterza B,Balestra MR,Deraco M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Neuroendocrine tumors are becoming increasingly prevalent, with many patients presenting with or developing metastatic disease to the liver. METHODS:In this landmark series paper, we highlight the critical studies that have defined the surgical management of neuroendocrine tumor liver metastases, as well as...

journal_title：Annals of surgical oncology

authors： Gangi A,Howe JR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the feasibility and optimal timing of quality of life assessment for patients undergoing palliative surgical evaluation. METHODS:Patients with an advanced malignancy undergoing consultation for palliative surgical intervention were prospectively enrolled from Novem...

journal_title：Annals of surgical oncology

authors： Badgwell B,Krouse R,Cormier J,Guevara C,Klimberg VS,Ferrell B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Clinical trials report improved overall survival following neoadjuvant chemoradiotherapy in patients undergoing surgery for esophageal adenocarcinoma, with a 10-15% survival improvement. MicroRNAs (miRNAs) are small noncoding RNAs that are known to direct the behavior of cancers, including response to treatm...

journal_title：Annals of surgical oncology

authors： Chiam K,Mayne GC,Watson DI,Woodman RJ,Bright TF,Michael MZ,Karapetis CS,Irvine T,Phillips WA,Hummel R,Wang T,Pimlott LK,Marri S,Astill DS,Ruszkiewicz AR,Thompson SK,Hussey DJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Magnetic resonance cholangiopancreatography (MRCP) is a new noninvasive diagnostic method for pancreaticobiliary (PB) imaging without endoscopy, sedation, or iodinated contrast. The purpose of this study was to evaluate the ability of MRCP to depict pancreatic and biliary ductal anatomy compared to that of e...

journal_title：Annals of surgical oncology

authors： Feldman DR,Kulling DP,Kay CL,Cole DJ,Cunningham JT,Hawes RH,Tarnasky PR,Cotton PB,Baron PL

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Little is known about metastatic patterns in patients with obstructing colorectal cancer (CRC). OBJECTIVE:The aim of this study was to determine if metastatic patterns in patients with CRC differ between patients with or without obstruction. METHODS:This single-center, observational, retrospective cohort s...

journal_title：Annals of surgical oncology

authors： Boeding JRE,Ramphal W,Crolla RMPH,Gobardhan PD,Schreinemakers JMJ

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The treatment of Wilms' tumor has undergone major advances in the past four decades. Current therapy is based on both the stage and pathology of the tumor. We have reviewed our recent experience with this tumor to assess the results of treatment on protocols that generally avoid the use of doxorubicin. METH...

journal_title：Annals of surgical oncology

authors： Shamberger RC,Macklis RM,Sallan SE

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The American Joint Committee on Cancer (AJCC) substantially changed the staging of cutaneous squamous cell carcinoma (cSCC) in the 7th edition of its staging manual. We aim to compare the 7th edition AJCC staging of nodal metastases from cSCC with the N1S3 staging system. METHODS:Analysis of 603 patients fr...

journal_title：Annals of surgical oncology

authors： Clark JR,Rumcheva P,Veness MJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Biomarkers for accurate diagnosis of early hepatocellular carcinoma (HCC) are limited in number and clinical validation. We applied SELDI-TOF-MS ProteinChip technology to identify serum profile for distinguishing HCC and liver cirrhosis (LC) and to compare the accuracy of SELDI-TOF-MS profile and alpha-fetop...

journal_title：Annals of surgical oncology

authors： Chen L,Ho DW,Lee NP,Sun S,Lam B,Wong KF,Yi X,Lau GK,Ng EW,Poon TC,Lai PB,Cai Z,Peng J,Leng X,Poon RT,Luk JM

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Melphalan (L-PAM) hyperthermic isolated limb perfusion (HILP) is currently considered the standard treatment for patients with in-transit metastases from cutaneous melanoma. We here report on the results of L-PAM and low-dose tumor necrosis factor (TNF)alpha HILP in patients with bulky disease. METHODS:Twen...

journal_title：Annals of surgical oncology

authors： Rossi CR,Foletto M,Mocellin S,Pilati P,Lise M

更新日期：2004-02-01 00:00:00

abstract：:The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts including surgical oncologists, medical oncologists, patho...

journal_title：Annals of surgical oncology

authors： Chicago Consensus Working Group.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer. MiRNA-205 has tumor suppressive properties, whereas miRNA-18a has both oncogenic and tumor suppressive roles. MiRNA-744's role in breast cancer is unknown but is tumor-suppressive in vitro. We hypothesize that hig...

journal_title：Annals of surgical oncology

authors： Kim SY,Kawaguchi T,Yan L,Young J,Qi Q,Takabe K

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The optimal tumor-free margin width remains controversial and may be inappropriate to investigate without considering differences in the underlying tumor biology. METHODS:R1 resection was defined as margin clearance less than 1 mm. R0 resection was further divided into 3 groups: 1-4, 5-9, and ≥10 mm. The im...

journal_title：Annals of surgical oncology

authors： Margonis GA,Sasaki K,Andreatos N,Kim Y,Merath K,Wagner D,Wilson A,Buettner S,Amini N,Antoniou E,Pawlik TM

更新日期：2017-01-01 00:00:00

abstract：:Hilar cholangiocarcinoma is an uncommon cause of malignant biliary obstruction marked by local tumor spread for which surgery offers the only chance of cure. The diagnostic evaluation and surgical management of this disease continues to evolve. Although direct cholangiography and endoscopic biliary procedures have bee...

journal_title：Annals of surgical oncology

authors： Chamberlain RS,Blumgart LH

更新日期：2000-01-01 00:00:00

abstract：:Many examples highlight the power of gene expression profiles, or signatures, to provide an understanding of biological phenotypes. This is best seen in the context of cancer, where expression signatures have tremendous power to identify new cancer subtypes and to predict clinical outcomes. Gene expression profiles ha...

journal_title：Annals of surgical oncology

authors： Stevenson M,Potti A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown....

journal_title：Annals of surgical oncology

authors： Nishigori T,Tsunoda S,Obama K,Hisamori S,Hashimoto K,Itatani Y,Okada K,Sakai Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The efficacy, toxicity, and patterns of failure of esophageal squamous cell carcinoma (ESCC) treated with selective lymph node (SLN) conventional fraction radiotherapy (CFRT) and S-1 plus cisplatin (CDDP) were evaluated. PATIENTS AND METHODS:67 Patients with clinical stage II-IVa ESCC were enrolled. The tot...

journal_title：Annals of surgical oncology

authors： Wang X,Liu X,Li D,Wang X,Huang W,Li B

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:To reject the hypothesis that the number of nodes removed at time of surgical staging for vulva cancer is not an important prognostic factor. METHODS:Retrospective chart reviews were carried out from 1980-2004 to identify patients with squamous cell vulva carcinoma treated with radical vulvectomy and bilate...

journal_title：Annals of surgical oncology

authors： Le T,Elsugi R,Hopkins L,Faught W,Fung-Kee-Fung M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:We provide a statistical analysis of the learning phase for sentinel node biopsy. METHODS:Four learning phases were analyzed: 25, 50, 75, and 150 procedures with a corresponding number of 10, 20, 30, and 60 tumor-positive cases. Critical values of nonidentification rate and false-negative rate were defined....

journal_title：Annals of surgical oncology

authors： Tanis PJ,Nieweg OE,Hart AA,Kroon BB

更新日期：2002-03-01 00:00:00

abstract：: ...

journal_title：Annals of surgical oncology

authors： Petrillo M,Scambia G,Fagotti A

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node ...

journal_title：Annals of surgical oncology

authors： Bae SU,Han YD,Cho MS,Hur H,Min BS,Baik SH,Lee KY,Kim NK

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The optimal time interval to define early recurrence (ER) among patients who underwent resection of gallbladder cancer (GBC) is not well defined. We sought to develop and validate a novel GBC recurrence risk (GBRR) score to predict ER among patients undergoing resection for GBC. PATIENTS AND METHODS:Patient...

journal_title：Annals of surgical oncology

authors： Sahara K,Tsilimigras DI,Kikuchi Y,Ethun CG,Maithel SK,Abbott DE,Poultsides GA,Hatzaras I,Fields RC,Weiss M,Scoggins C,Isom CA,Idrees K,Shen P,Yabushita Y,Matsuyama R,Endo I,Pawlik TM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the prognostic value of positive posterior superior pancreaticoduodenal lymph nodes to clarify the need for dissection of these nodes. METHODS:A total of 148 patients with gallbladder carcinoma who underwent radical resection including dissection of the posterior superior...

journal_title：Annals of surgical oncology

authors： Sakata J,Kobayashi T,Tajima Y,Ohashi T,Hirose Y,Takano K,Takizawa K,Miura K,Wakai T

更新日期：2017-09-01 00:00:00