当前位置： SCI文献检索 > ANNALS OF SURGICAL ONCOLOGY期刊下所有文献 > Frequent and early death limits quality of life assessment in patients with advanced malignancies evaluated for palliative surgical intervention.

Frequent and early death limits quality of life assessment in patients with advanced malignancies evaluated for palliative surgical intervention.

Abstract：

BACKGROUND:The purpose of this study was to determine the feasibility and optimal timing of quality of life assessment for patients undergoing palliative surgical evaluation. METHODS:Patients with an advanced malignancy undergoing consultation for palliative surgical intervention were prospectively enrolled from November 2009 to January 2011. Follow-up quality of life assessment was performed using validated instruments at 1 and 3 months post-enrollment. Univariate analysis of variables was performed to identify clinicopathologic variables associated with questionnaire completion. RESULTS:Of 77 patients enrolled, the most common clinical presentations included bowel obstruction (32 %), abdominal pain (21 %), wound complications (18 %), and gastrointestinal bleeding (11 %). Of the 77 patients, 34 (44 %) were treated with nonoperative/nonprocedural care, 9 (12 %) with endoscopic or interventional radiologic procedures, and 34 (44 %) with surgery. Follow-up questionnaires were obtained at 1 month and 3 months in 48 % and 15 %, respectively. A total of 31 patients (40 %) died prior to study completion. On univariate analysis, death was the only factor associated with questionnaire response. All other demographic, clinical, and treatment variables were not associated with response to questionnaires. There were no significant differences in baseline or follow-up quality of life scores between patients treated with surgical intervention or nonoperative management. CONCLUSIONS:Death during the study period was a significant factor in limiting adequate follow-up assessment. Future studies attempting to obtain follow-up data on patients evaluated for palliative surgical intervention may require larger patient numbers to account for frequent early death in this population and anticipate the need to account for the high rate of missing data in statistical analysis.

journal_name

Ann Surg Oncol

journal_title

Annals of surgical oncology

authors

Badgwell B,Krouse R,Cormier J,Guevara C,Klimberg VS,Ferrell B

doi

10.1245/s10434-012-2420-5

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

3651-8

issue

eissn

1068-9265

issn

1534-4681

journal_volume

pub_type

杂志文章

在线工具

Frequent and early death limits quality of life assessment in patients with advanced malignancies evaluated for palliative surgical intervention.