No evidence for a low linear energy transfer adaptive response in irradiated RKO cells.

Abstract:

:It has become increasingly evident from reports in the literature that there are many confounding factors capable of modulating radiation-induced non-targeted responses, such as the bystander effect and the adaptive response. In this paper, we examine recent data which suggest that the observation of non-targeted responses may not be universally observable for differing radiation qualities. We have conducted a study of the adaptive response following low-linear energy transfer exposures for human colon carcinoma cells and failed to observe adaption for the endpoints of clonogenic survival or micronucleus formation.

journal_name

Radiat Prot Dosimetry

authors

Sowa MB,Goetz W,Baulch JE,Lewis AJ,Morgan WF

doi

10.1093/rpd/ncq487

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

311-4

issue

2-4

eissn

0144-8420

issn

1742-3406

pii

ncq487

journal_volume

143

pub_type

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