Using simple mathematical functions to simulate pathological structures--input for digital mammography clinical trial.

Abstract:

:In this study a set of structures has been simulated to represent a range of clinically relevant breast cancer mammographic lesions including solid tumours and microcalcifications. All structures have been created using simple random-based mathematical functions and have been inserted into a subset of digital mammography images at appropriate contrast levels into various regions of the breast, including dense fibroglandular and adipose tissue. These structures and their appearance in these clinical images were evaluated in terms of how realistic they looked. They will be used as the input to a large-scale clinical trial designed to examine the effect of significant dose reduction in digital mammography by comparing the detectability of such structures in images acquired at full and quarter automatic exposure control (AEC) dose level and in images with simulated noise levels in between.

journal_name

Radiat Prot Dosimetry

authors

Ruschin M,Tingberg A,Båth M,Grahn A,Håkansson M,Hemdal B,Andersson I

doi

10.1093/rpd/nch552

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

424-31

issue

1-3

eissn

0144-8420

issn

1742-3406

pii

114/1-3/424

journal_volume

114

pub_type

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