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Applications for T-cell epitope queries and tools in the Immune Epitope Database and Analysis Resource.

Abstract：

:The Immune Epitope Database and Analysis Resource (IEDB, http://www.iedb.org) hosts a continuously growing set of immune epitope data curated from the literature, as well as data submitted directly by experimental scientists. In addition, the IEDB hosts a collection of prediction tools for both MHC class I and II restricted T-cell epitopes that are regularly updated. In this review, we provide an overview of T-cell epitope data and prediction tools provided by the IEDB. We then illustrate effective use of these resources to support experimental studies. We focus on two applications, namely identification of conserved epitopes in novel strains of a previously studied pathogen, and prediction of novel T-cell epitopes to facilitate vaccine design. We address common questions and concerns faced by users, and identify patterns of usage that have proven successful.

journal_name

J Immunol Methods

journal_title

Journal of immunological methods

authors

Kim Y,Sette A,Peters B

doi

10.1016/j.jim.2010.10.010

subject

Has Abstract

pub_date

2011-11-30 00:00:00

pages

62-9

issue

1-2

eissn

0022-1759

issn

1872-7905

pii

S0022-1759(10)00322-4

journal_volume

374

pub_type

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