FERONIA receptor-like kinase regulates RHO GTPase signaling of root hair development.

abstract：:To maintain genome stability, cells with damaged DNA must arrest to allow repair of mutations before replication. Although several key components required to elicit this arrest have been discovered, much of the pathway remains elusive. Here we report that pRB acts as a central mediator of the proliferative block induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrington EA,Bruce JL,Harlow E,Dyson N

更新日期：1998-09-29 00:00:00

abstract：:As a first step in assessing the efficacy of a gene transfer approach to the induction of transplantation tolerance in our miniature swine model, double-copy retroviral vectors engineered to express a drug-resistance marker (neomycin) and a swine class II DRB cDNA were constructed. Infectious particles containing thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafer GE,Emery DW,Gustafsson K,Germana S,Anderson WF,Sachs DH,LeGuern C

更新日期：1991-11-01 00:00:00

abstract：:Adenosine deaminases that act on RNA (ADARs) constitute a family of RNA-editing enzymes that convert adenosine to inosine within double-stranded regions of RNA. We previously developed a method to identify inosine-containing RNAs and used it to identify five ADAR substrates in Caenorhabditis elegans. Here we use the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse DP,Aruscavage PJ,Bass BL

更新日期：2002-06-11 00:00:00

abstract：:The guanosine hydrazide 1 yields a stable supramolecular hydrogel based on the formation of a guanine quartet (G-quartet) in presence of metal cations. The effect of various parameters (concentration, nature of metal ion, and temperature) on the properties of this gel has been studied. Proton NMR spectroscopy is shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sreenivasachary N,Lehn JM

更新日期：2005-04-26 00:00:00

abstract：:It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobitz B,Beck L,Huq A,Wood B,Fuchs G,Faruque AS,Colwell R

更新日期：2000-02-15 00:00:00

abstract：:Calcium-dependent protein kinases (CDPKs) comprise the major group of Ca2+-regulated kinases in plants and protists. It has long been assumed that CDPKs are activated, like other Ca2+-regulated kinases, by derepression of the kinase domain (KD). However, we found that removal of the autoinhibitory domain from Toxoplas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingram JR,Knockenhauer KE,Markus BM,Mandelbaum J,Ramek A,Shan Y,Shaw DE,Schwartz TU,Ploegh HL,Lourido S

更新日期：2015-09-08 00:00:00

abstract：:Nitric oxide (NO) and reactive oxygen species (ROS) act independently as well as cooperatively to induce neuronal death in acute neurological disorders. Inhibition of neuronal nitric oxide synthase (nNOS) and inhibition of lipid peroxidation induced by ROS have both been proposed as neuroprotective strategies in strok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chabrier PE,Auguet M,Spinnewyn B,Auvin S,Cornet S,Demerlé-Pallardy C,Guilmard-Favre C,Marin JG,Pignol B,Gillard-Roubert V,Roussillot-Charnet C,Schulz J,Viossat I,Bigg D,Moncada S

更新日期：1999-09-14 00:00:00

abstract：:We previously reported that KIF3A and KIF3B form a heterodimer that functions as a microtubule-based fast anterograde translocator of membranous organelles. We have also shown that this KIF3A/3B forms a complex with other associated polypeptides, named kinesin superfamily-associated protein 3 (KAP3). In the present st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki H,Nakata T,Okada Y,Hirokawa N

更新日期：1996-08-06 00:00:00

abstract：:Transcriptional regulation by nuclear hormone receptors is thought to involve interactions with putative cofactors that may potentiate receptor function. Here we show that human thyroid hormone receptor alpha purified from HeLa cells grown in the presence of thyroid hormone (T3) is associated with a group of distinct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fondell JD,Ge H,Roeder RG

更新日期：1996-08-06 00:00:00

abstract：:A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide suff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansson MA,Apfeldorf KM,Dobson S,Devita J,Buczak AL,Baugher B,Moniz LJ,Bagley T,Babin SM,Guven E,Yamana TK,Shaman J,Moschou T,Lothian N,Lane A,Osborne G,Jiang G,Brooks LC,Farrow DC,Hyun S,Tibshirani RJ,Rosenfe

更新日期：2019-11-26 00:00:00

abstract：:Sera from 11 individuals which were classified as Lp(a-) by direct gel diffusion and by absorption tests showed the presence of Lp(a) lipoprotein when the sera were concentrated 120-fold. This Lp(a) antigen was demonstrated by gel diffusion to be indistinguishable from Lp-lipoprotein isolated from known Lp(a+) sera. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvie NR,Schultz JS

更新日期：1970-05-01 00:00:00

abstract：:Nociceptive information is modulated by a large number of endogenous signaling agents that change over the course of recovery from injury. This plasticity makes understanding regulatory mechanisms involved in descending inhibition of pain scientifically and clinically important. Neurons that synthesize the neuropeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimitrov EL,Kuo J,Kohno K,Usdin TB

更新日期：2013-08-06 00:00:00

abstract：:Hairs, feathers, and scales normally exhibit precise orientations with respect to the body axes. In Frizzled6 (Fz6)(-/-) mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs. By analyzing the orientation of developing hair follicles, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Badea T,Nathans J

更新日期：2006-12-26 00:00:00

abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

更新日期：2009-12-01 00:00:00

abstract：:Fanconi anemia (FA) is caused by defects in cellular responses to DNA crosslinking damage and replication stress. Given the constant occurrence of endogenous DNA damage and replication fork stress, it is unclear why complete deletion of FA genes does not have a major impact on cell proliferation and germ-line FA patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang R,Lenoir WF,Wang C,Su D,McLaughlin M,Hu Q,Shen X,Tian Y,Klages-Mundt N,Lynn E,Wood RD,Chen J,Hart T,Li L

更新日期：2020-12-29 00:00:00

abstract：:Here we describe two mammalian transcription factors selectively expressed in the central nervous system. Both proteins, neuronal PAS domain protein (NPAS) 1 and NPAS2, are members of the basic helix-loop-helix-PAS family of transcription factors. cDNAs encoding mouse and human forms of NPAS1 and NPAS2 have been isola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou YD,Barnard M,Tian H,Li X,Ring HZ,Francke U,Shelton J,Richardson J,Russell DW,McKnight SL

更新日期：1997-01-21 00:00:00

abstract：:Chromosomal RNA was isolated from several rat tissues by a new technique. It is shown by RNA-DNA hybridization that each tissue contains a distinct population of chromosomal RNA sequences. This finding is compatible with the proposal that chromosomal RNA is involved in the process of gene activation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayfield JE,Bonner J

更新日期：1971-11-01 00:00:00

abstract：:A sensitive assay for detection of eukaryotic RNA polymerase II has been developed. This assay depends on the ability of polymerase II to elongate a small RNA primer, oligo(U), hybridized to a single-stranded homopolymeric DNA template, poly(dA). The poly(dA).oligo(U)-dependent RNA polymerase II from calf thymus has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fradkin LG,Leong K,Morrow CD,Berk AJ,Dasgupta A

更新日期：1985-12-01 00:00:00

abstract：:The domestication of cultivated barley has been used as a model system for studying the origins and early spread of agrarian culture. Our previous results indicated that the Tibetan Plateau and its vicinity is one of the centers of domestication of cultivated barley. Here we reveal multiple origins of domesticated bar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dai F,Chen ZH,Wang X,Li Z,Jin G,Wu D,Cai S,Wang N,Wu F,Nevo E,Zhang G

更新日期：2014-09-16 00:00:00

abstract：:During the early evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin capable of repairing cyclobutane pyrimidine dimers in DNA or RNA by photoinduced electron transfer using longer wavelength UVB radiation. To investigate the ability of O to act as an excited-state electron...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Dood J,Beckstead AA,Li XB,Nguyen KV,Burrows CJ,Improta R,Kohler B

更新日期：2014-08-12 00:00:00

abstract：:Measles virus (MeV) is the poster child for acute infection followed by lifelong immunity. However, recent work shows the presence of MeV RNA in multiple sites for up to 3 mo after infection in a proportion of infected children. Here, we use experimental infection of rhesus macaques to show that prolonged RNA presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Kouyos RD,Adams RJ,Grenfell BT,Griffin DE

更新日期：2012-09-11 00:00:00

abstract：:Paired oxygen-isotopic analyses of abiotic carbonate and benthic-ostracode shells from lake sediments provide a continuous quantitative record of growing-season temperature for the past 2000 years in the northwestern foothills of the Alaska Range. This record reveals three time intervals of comparable warmth: anno Dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu FS,Ito E,Brown TA,Curry BB,Engstrom DR

更新日期：2001-09-11 00:00:00

abstract：:Here we study the effects of many-body interactions on rate and mechanism in protein folding by using the results of molecular dynamics simulations on numerous coarse-grained Calpha-model single-domain proteins. After adding three-body interactions explicitly as a perturbation to a Gō-like Hamiltonian with native pair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ejtehadi MR,Avall SP,Plotkin SS

更新日期：2004-10-19 00:00:00

abstract：:The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs) assume a β-barrel fold, and some form aqueous channels for nutrient uptake and efflux of intracellular toxins. The Bam machine catalyzes rapid folding and assembly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konovalova A,Grabowicz M,Balibar CJ,Malinverni JC,Painter RE,Riley D,Mann PA,Wang H,Garlisi CG,Sherborne B,Rigel NW,Ricci DP,Black TA,Roemer T,Silhavy TJ,Walker SS

更新日期：2018-07-10 00:00:00

abstract：:The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has been studied in considerable detail, but the importance of farnesylation for the B-type lamins, lamin B1 and lamin B2, has received little attention. Lamins B1 and B2 are expressed in nearly every cell type from the earliest s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung HJ,Nobumori C,Goulbourne CN,Tu Y,Lee JM,Tatar A,Wu D,Yoshinaga Y,de Jong PJ,Coffinier C,Fong LG,Young SG

更新日期：2013-05-21 00:00:00

abstract：:In all but the poorest countries of South Asia and Africa, the supply and quality of food will rise to meet the demand. Biotechnology, accelerated by genomics, will create wealth for both producers and consumers by reducing the cost and increasing the quality of food. Famine and malnutrition in the poorest countries m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briggs SP

更新日期：1998-03-03 00:00:00

abstract：:Using morphometrical methods, we investigated variation in the skeletons of more than 400 offspring of C57BL/6J and DBA/2J male mice that had received either a 250 mg/kg dose of the mutagen ethylnitrosourea or a solvent control. Sperm involved in the matings developed from cells in the spermatogonial stage at the time...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovell DP,Willis DB,Johnson FM

更新日期：1985-05-01 00:00:00

abstract：:Although normal fatty acids (FAs) are degraded via β-oxidation, unusual FAs such as 2-hydroxy (2-OH) FAs and 3-methyl-branched FAs are degraded via α-oxidation. Phytosphingosine (PHS) is one of the long-chain bases (the sphingolipid components) and exists in specific tissues, including the epidermis and small intestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitamura T,Seki N,Kihara A

更新日期：2017-03-28 00:00:00

abstract：:Structural symmetry is a hallmark of homomeric ion channels. Nonobligatory regulatory proteins can also critically define the precise functional role of such channels. For instance, the pore-forming subunit of the large conductance voltage and calcium-activated potassium (BK, Slo1, or KCa1.1) channels encoded by a sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Perez V,Ben Johny M,Xia XM,Lingle CJ

更新日期：2018-10-02 00:00:00

abstract：:The bacterial adaptive immune system CRISPR-Cas9 has been appropriated as a versatile tool for editing genomes, controlling gene expression, and visualizing genetic loci. To analyze Cas9's ability to bind DNA rapidly and specifically, we generated multiple libraries of potential binding partners for measuring the kine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyle EA,Andreasson JOL,Chircus LM,Sternberg SH,Wu MJ,Guegler CK,Doudna JA,Greenleaf WJ

更新日期：2017-05-23 00:00:00