AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation.

abstract：:The exemplary search capabilities of flying insects have established them as one of the most diverse taxa on Earth. However, we still lack the fundamental ability to quantify, represent, and predict trajectories under natural contexts to understand search and its applications. For example, flying insects have evolved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaushik PK,Renz M,Olsson SB

更新日期：2020-06-02 00:00:00

abstract：:In oxygenic photosynthetic eukaryotes, the hydroxylated carotenoid zeaxanthin is produced from preexisting violaxanthin upon exposure to excess light conditions. Zeaxanthin binding to components of the photosystem II (PSII) antenna system has been investigated thoroughly and shown to help in the dissipation of excess ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballottari M,Alcocer MJ,D'Andrea C,Viola D,Ahn TK,Petrozza A,Polli D,Fleming GR,Cerullo G,Bassi R

更新日期：2014-06-10 00:00:00

abstract：:Island biogeography theory posits that species richness increases with island size and decreases with isolation. This logic underpins much conservation policy and regulation, with preference given to conserving large, highly connected areas, and relative ambivalence shown toward protecting small, isolated habitat patc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wintle BA,Kujala H,Whitehead A,Cameron A,Veloz S,Kukkala A,Moilanen A,Gordon A,Lentini PE,Cadenhead NCR,Bekessy SA

更新日期：2019-01-15 00:00:00

abstract：:Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with beta-sandwich architecture. Herein, we propose by stretching two model sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimov DK,Thirumalai D

更新日期：2000-06-20 00:00:00

abstract：:Photoreceptors of the Xenopus laevis retina are the site of a circadian clock. As part of a differential display screen for rhythmic gene products in this system, we have identified a photoreceptor-specific mRNA expressed in peak abundance at night. cDNA cloning revealed an open reading frame encoding a putative 388 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green CB,Besharse JC

更新日期：1996-12-10 00:00:00

abstract：:Recent structural studies of the minimal core DNA-binding domain of p53 (p53DBD) complexed to a single consensus pentamer sequence and of the isolated p53 tetramerization domain have provided valuable insights into their functions, but many questions about their interacting roles and synergism remain unanswered. To be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balagurumoorthy P,Sakamoto H,Lewis MS,Zambrano N,Clore GM,Gronenborn AM,Appella E,Harrington RE

更新日期：1995-09-12 00:00:00

abstract：:The p53 protein is an attractive target for immunotherapy, because mutations in the p53 gene are the most common genetic alterations found in human tumors. These mutations result in high levels of p53 protein in the tumor cell, whereas the expression level of wild-type p53 in nonmalignant tissue is usually much lower....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth J,Dittmer D,Rea D,Tartaglia J,Paoletti E,Levine AJ

更新日期：1996-05-14 00:00:00

abstract：:The stimulatory activity of peptides from the alpha 1 domain of the major histocompatibility complex (MHC) class I antigen on adipose cell glucose transport was previously shown to require a preformed, ordered conformation of the peptide. The two peptides studied previously were Dk-(61-85) (ERETQIAKGNEQSFRVDLRTLLRYY) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagsted J,Mapelli C,Meyers C,Matthews BW,Anfinsen CB,Goldstein A,Olsson L

更新日期：1993-08-15 00:00:00

abstract：:Oligothiophenes incorporating MM quadruple bonds have been prepared from the reactions between Mo(2)(TiPB)(4) (TiPB = 2,4,6-triisopropyl benzoate) and 3',4'-dihexyl-2,2'-:5',2''-terthiophene-5,5''-dicarboxylic acid. The oligomers of empirical formula Mo(2)(TiPB)(2)(O(2)C(Th)-C(4)(n-hexyl)(2)S-(Th)CO(2)) are soluble in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdzinski GT,Chisholm MH,Chou PT,Chou YH,Feil F,Gallucci JC,Ghosh Y,Gustafson TL,Ho ML,Liu Y,Ramnauth R,Turro C

更新日期：2008-10-07 00:00:00

abstract：:Human lymphocytes obtained from fasted adult subjects and cultured human tumor lymphocytes were investigated for specific insulin receptors. By use of monoiodoinsulin, specific insulin binding sites were demonstrated in peripheral human lymphocytes, cultured human lymphocytes, and in other types of human circulating c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavin JR 3rd,Roth J,Jen P,Freychet P

更新日期：1972-03-01 00:00:00

abstract：:A model is presented for age-specific selection on the genotypes in a population. Each genotype is assigned a life table that specifies the viability and fecundity of its age classes. Breeding and reproduction occur at regular intervals, and generations overlap. Examples were generated on a digital computer. Gene freq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,King CE

更新日期：1970-07-01 00:00:00

abstract：:In spite of the critical role of the process of adaptation in evolution, there are few detailed studies of the genotypic and molecular basis of the process. Drosophila melanogaster flies selected for increased tolerance to ethanol exhibited higher levels of alcohol dehydrogenase (alcohol:NAD+ oxidoreductase; EC 1.1.1....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDonald JF,Chambers GK,David J,Ayala FJ

更新日期：1977-10-01 00:00:00

abstract：:We describe the use of a series of gradually expanded thymine nucleobase analogs in probing steric effects in DNA polymerase efficiency and fidelity. In these nonpolar compounds, the base size was increased incrementally over a 1.0-A range by use of variably sized atoms (H, F, Cl, Br, and I) to replace the oxygen mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim TW,Delaney JC,Essigmann JM,Kool ET

更新日期：2005-11-01 00:00:00

abstract：:Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their charac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frantz LAF,Haile J,Lin AT,Scheu A,Geörg C,Benecke N,Alexander M,Linderholm A,Mullin VE,Daly KG,Battista VM,Price M,Gron KJ,Alexandri P,Arbogast RM,Arbuckle B,Bӑlӑşescu A,Barnett R,Bartosiewicz L,Baryshnikov G,Bons

更新日期：2019-08-27 00:00:00

abstract：:Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates the enzymatic activity of Sipa1. In vitro analysis of a highly metastatic mouse mammary tumor cell line ectopically expressing Brd4 demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crawford NP,Alsarraj J,Lukes L,Walker RC,Officewala JS,Yang HH,Lee MP,Ozato K,Hunter KW

更新日期：2008-04-29 00:00:00

abstract：:Monospecific antibodies were produced in vitro by fusing mouse myeloma cells with spleen cells from a BALB/c mouse immunized with rat skeletal myofibrils. After cloning 3 times on agarose, two stable clones were obtained and chosen for further characterization. The first clone, JLB1, produced an antibody that recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin JJ

更新日期：1981-04-01 00:00:00

abstract：:Current issues pertaining to theoretical simulations of materials, with a focus on systems of nanometer-scale dimensions, are discussed. The use of atomistic simulations as high-resolution numerical experiments, enabling and guiding formulation and testing of analytic theoretical descriptions, is demonstrated through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landman U

更新日期：2005-05-10 00:00:00

abstract：:YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to experimental animal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin E,Lee YC,Murad F

更新日期：2001-11-06 00:00:00

abstract：:The membrane proteins of peripheral light-harvesting complexes (LHCs) bind chlorophylls and carotenoids and transfer energy to the reaction centers for photosynthesis. LHCs of chlorophytes, chromophytes, dinophytes, and rhodophytes are similar in that they have three transmembrane regions and several highly conserved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grabowski B,Cunningham FX Jr,Gantt E

更新日期：2001-02-27 00:00:00

abstract：:For several decades, the iron-based Fenton-like catalysis has been believed to be mediated by hydroxyl radicals or high-valent iron-oxo species, while only sporadic evidence supported the generation of singlet oxygen (1O2) in the Haber-Weiss cycle. Herein, we report an unprecedented singlet oxygen mediated Fenton-like...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Qian J,Yu A,Pan B

更新日期：2019-04-02 00:00:00

abstract：:In our 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY experiment, the TROSY principle (transverse relaxation-optimized spectroscopy) is used in three-dimensional (3D) (15)N-resolved nuclear Overhauser enhancement spectroscopy (NOESY), which enables resonance assignments by sequential nuclear Overhauser effects and the collection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pervushin KV,Wider G,Riek R,Wüthrich K

更新日期：1999-08-17 00:00:00

abstract：:The guanosine hydrazide 1 yields a stable supramolecular hydrogel based on the formation of a guanine quartet (G-quartet) in presence of metal cations. The effect of various parameters (concentration, nature of metal ion, and temperature) on the properties of this gel has been studied. Proton NMR spectroscopy is shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sreenivasachary N,Lehn JM

更新日期：2005-04-26 00:00:00

abstract：:Overexpression of human cyclooxygenase 2 (COX-2) in the mammary glands of transgenic mice induces tissue-specific tumorigenic transformation. However, the molecular mechanisms involved are not yet defined. Here we show that COX-2 expressed in the epithelial cell compartment regulates angiogenesis in the stromal tissue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SH,Liu CH,Conway R,Han DK,Nithipatikom K,Trifan OC,Lane TF,Hla T

更新日期：2004-01-13 00:00:00

abstract：:A number of distressing trends, including a decline in the share of key research grants going to younger scientists, as well as a steady rise in the age at which investigators receive their first funding, are now a decades-long feature of the US biomedical research workforce. Working committees have proposed recommend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels RJ

更新日期：2015-01-13 00:00:00

abstract：:We simulated the behavior of suspended carbon nanotube resonators over a broad range of temperatures to explore the physics of semiflexible polymers in underdamped environments. We find that thermal fluctuations induce strong coupling between resonance modes. This effect leads to spectral fluctuations that readily acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnard AW,Sazonova V,van der Zande AM,McEuen PL

更新日期：2012-11-20 00:00:00

abstract：:There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duscher D,Neofytou E,Wong VW,Maan ZN,Rennert RC,Inayathullah M,Januszyk M,Rodrigues M,Malkovskiy AV,Whitmore AJ,Walmsley GG,Galvez MG,Whittam AJ,Brownlee M,Rajadas J,Gurtner GC

更新日期：2015-01-06 00:00:00

abstract：:HUMAN LIVER ALCOHOL DEHYDROGENASE (ALCOHOL: NAD(+) oxidoreductase, EC 1.1.1.1), homogeneous by physicochemical criteria, has been available in quantity only recently [Lange, L. G. & Vallee, B. L. (1976) Biochemistry 15, 4681-4686]. Until now, the biochemical basis of human alcohol metabolism had to be extrapolated fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li TK,Bosron WF,Dafeldecker WP,Lange LG,Vallee BL

更新日期：1977-10-01 00:00:00

abstract：:The "WD40" domain is a widespread recognition module for linking partner proteins in intracellular networks of signaling and sorting. The clathrin amino-terminal domain, which directs incorporation of cargo into coated pits, is a beta-propeller closely related in structure to WD40 modules. The crystallographically det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： ter Haar E,Harrison SC,Kirchhausen T

更新日期：2000-02-01 00:00:00

abstract：:Theories of evolution that state natural selection acts on individuals have been modified to include multiple levels of selection. Here we demonstrate in chimeric protochordates that primitive germ cell (pgc) and somatic cell (psc) lineages have traits that also make them likely units of natural selection. Specificall...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoner DS,Rinkevich B,Weissman IL

更新日期：1999-08-03 00:00:00

abstract：:Beta subunits of voltage-gated Ca2+ channels are encoded in four genes and display additional molecular diversity because of alternative splicing. At the functional level, all forms are very similar except for beta2a, which differs in that it does not support prepulse facilitation of alpha1C Ca2+ channels, inhibits vo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin N,Platano D,Olcese R,Costantin JL,Stefani E,Birnbaumer L

更新日期：1998-04-14 00:00:00