Abstract：
AIMS:To determine the gender-specific incidence and risk factors of type-2 diabetes mellitus (T2DM) in a general population. METHODS:The study is based on 12,431 men and 13,737 women aged 25-98 years, attending the Tromsø Study in 1994 and followed through 2005, who did not have diabetes when entering the study. Sex-specific hazard ratios were estimated from Cox proportional hazard models. RESULTS:A total of 522 cases of T2DM were registered, 308 among men and 214 among women. The age-standardised incidence rate was higher in men than in women, 2.6 (95% CI 2.32-2.90) and 1.6(95% CI 1.40-1.83) per 1000 person-years, respectively. In multivariate survival analysis, age, body mass index (BMI),triglycerides, high-density lipoprotein (HDL) cholesterol, hypertension, family history of diabetes, low education and smoking were independent predictors of T2DM in both genders (p<0.05). Total cholesterol and lack of leisure-time physical activity were independent predictors in men only. We found an interaction between HDL cholesterol and triglyceride levels(p<0.001) and between triglyceride levels and a positive family history of diabetes (p=.04). These interactions were independent of BMI. A positive family history combined with triglycerides in the highest tertile and BMI >25 kg/m(2) conveyed a 10-year risk of T2DM of 10% (95% CI 8-12%) vs. 0.2% (95% CI 0.08-0.31%) for the lowest risk group. CONCLUSIONS:A family history of diabetes, elevated BMI, and high triglyceride levels identifies independent of cardiovascular risk factors, a group with especially high risk of T2DM. [corrected]
journal_name
Scand J Public Healthjournal_title
Scandinavian journal of public healthauthors
Joseph J,Svartberg J,Njølstad I,Schirmer Hdoi
10.1177/1403494810380299subject
Has Abstractpub_date
2010-11-01 00:00:00pages
768-75issue
7eissn
1403-4948issn
1651-1905pii
1403494810380299journal_volume
38pub_type
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