Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases.

abstract：INTRODUCTION:CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here,...

journal_title：Expert review of clinical immunology

authors： França TT,Barreiros LA,Al-Ramadi BK,Ochs HD,Cabral-Marques O,Condino-Neto A

更新日期：2019-05-01 00:00:00

abstract：:Introduction: Inflammasomes are large multimeric intracellular complexes that are capable of maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to danger signal molecules. As a member of the inflammasome family, the NLRP3 inflammasome has recently been under intense investigation reve...

journal_title：Expert review of clinical immunology

authors： Gouravani M,Khalili N,Razi S,Keshavarz-Fathi M,Khalili N,Rezaei N

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:High mobility group protein box 1 (HMGB1) is a protein belonging to the alarmin family. HMGB1 has a relevant role in starting the inflammatory cascade by means of receptors, such as RAGE and TLR. HMGB1 supports transcription of many genes in interactions with many transcription factors, including NF-kB. Th...

journal_title：Expert review of clinical immunology

authors： Ciprandi G,Bellussi LM,Passali GC,Damiani V,Passali D

更新日期：2020-05-01 00:00:00

abstract：:Non-immediate drug reactions (NIR) are induced by specific immunological mechanisms and involve the recognition of hapten molecules by the immune system, with the participation of dendritic cells and other antigen-presenting cells. This process is followed by an effector response that can induce several clinical entit...

journal_title：Expert review of clinical immunology

authors： Perkins JR,Ariza A,Blanca M,Fernández TD

更新日期：2014-11-01 00:00:00

abstract：:Over the past few years, the therapeutic potential of Treg has been highlighted in the field of autoimmune diseases and after allogeneic transplantation. The first hurdle for the therapeutic use of Treg is their insufficient numbers in non-manipulated individuals, in particular when facing strong immune activation and...

journal_title：Expert review of clinical immunology

authors： Govender L,Pascual M,Golshayan D

更新日期：2014-09-01 00:00:00

abstract：:In current clinical practice, immune reactivity of kidney transplant recipients is estimated by monitoring the levels of immunosuppressive drugs, and by functional and/or histological evaluation of the allograft. The availability of assays that could directly quantify the extent of the recipient's immune response towa...

journal_title：Expert review of clinical immunology

authors： Cravedi P,Mannon RB

更新日期：2009-09-01 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT), both allogeneic and autologous, has become one of the hottest topics in clinical immunology. One of the main autoimmune diseases in which HSCT has been extensively tried during the last decade is multiple sclerosis (MS). A few original papers and many anecdotal reports h...

journal_title：Expert review of clinical immunology

authors： Karussis D,Vaknin-Dembinsky A

更新日期：2010-05-01 00:00:00

abstract：:Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mell...

journal_title：Expert review of clinical immunology

authors： Dalmády S,Kemény L,Antal M,Gyulai R

更新日期：2020-01-01 00:00:00

abstract：:Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations of linkage analysis, multiple genome-wide association studies, their meta-analyses, and targeted genotyping array techniques have broade...

journal_title：Expert review of clinical immunology

authors： Ye BD,McGovern DP

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Secukinumab, an interleukin-17A (IL-17A) antagonist, is the first non-TNF alpha inhibitor agent licensed for ankylosing spondylitis (AS), which opens up a new era of alternative cytokine targets beyond TNF. Areas covered: This review explores the pathophysiology and scientific evidence behind the use of th...

journal_title：Expert review of clinical immunology

authors： Dubash S,Bridgewood C,McGonagle D,Marzo-Ortega H

更新日期：2019-02-01 00:00:00

abstract：:Probiotics have had many applications in the past few years, and inflammatory conditions of the GI tract--including chronic disorders such as inflammatory bowel disease (IBD)--have received the most attention by investigators. In fact, the experimental basis to expect clinical efficacy of probiotics in IBD is quite ro...

journal_title：Expert review of clinical immunology

authors： Guandalini S

更新日期：2010-01-01 00:00:00

abstract：:Glucocorticoids are indispensable for the treatment of systemic inflammatory diseases such as rheumatoid arthritis (RA), though their beneficial effects have to be balanced with potential complications arising from high doses, prolonged use or dose splitting. A glucocorticoid formulation (modified-release prednisone) ...

journal_title：Expert review of clinical immunology

authors： Alten R

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:The transcription factors signal transducer and activator of transcription (STAT) 1 and STAT3 fulfill fundamental functions in nonimmune and immune cells. The description and follow-up of patients with germline mutations that result in either loss-of-function or gain-of-function have contributed to our und...

journal_title：Expert review of clinical immunology

authors： Olbrich P,Freeman AF

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is characterized by systemic synovitis causing joint destruction. With the development of biological disease-modifying anti-rheumatic drugs (bDMARDs) and combination of conventional DMARDs, clinical remission is perceived as an appropriate and realistic goal in many patients. Howe...

journal_title：Expert review of clinical immunology

authors： Kubo S,Nakayamada S,Tanaka Y

更新日期：2016-09-01 00:00:00

abstract：:Host susceptibility to environmental triggers is the most likely explanation for the development of asthma. Quantifying gene expression levels in disease-relevant tissues and cell types using fast evolving genomic technologies have generated new hypotheses about the pathogenesis of asthma and identified new therapeuti...

journal_title：Expert review of clinical immunology

authors： Bérubé JC,Bossé Y

更新日期：2014-08-01 00:00:00

abstract：:Evolving data have shown that the toll like receptors (TLRs) family of innate immune receptors has an important role in driving the activation and inhibition of pathogenic pathways involved in multiple sclerosis (MS). While developing clinical trials targeting MS by TLRs modulators are of considerable interest, severa...

journal_title：Expert review of clinical immunology

authors： Gooshe M,Aleyasin AR,Abdolghaffari AH,Rezaei N

更新日期：2014-10-01 00:00:00

abstract：:Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-aminosalicylic acid, which is available in several different formulations and dosing schedules. Several studies have demonstrated that adherence rates to prescribed 5-aminosalicylic acid products are below tho...

journal_title：Expert review of clinical immunology

authors： Bernick SJ,Kane S

更新日期：2010-07-01 00:00:00

abstract：:Metabolic syndrome is a highly atherogenic state in which hyperglycemia, dyslipidemia and hypertension cluster in one individual. Intra-abdominal visceral fat accumulation plays a key role in the development of these disorders and the occurrence of metabolic syndrome. We have investigated adipocyte functions intensive...

journal_title：Expert review of clinical immunology

authors： Matsuzawa Y

更新日期：2007-01-01 00:00:00

abstract：:The 12/15-lipoxygenase (LO) cascade governs the generation of 12-hydroperoxy-eicosatetraenoic acid (HPETE) and 15-HPETE from arachidonic acid. The 5-LO pathway plays a fundamental role in the biosynthesis of leukotrienes, essential inflammatory lipid mediators. Cyclooxygenase (COX)-1 and -2 biosynthetic pathways are r...

journal_title：Expert review of clinical immunology

authors： Zhao L,Grosser T,Fries S,Kadakia L,Wang H,Zhao J,Falotico R

更新日期：2006-07-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) represents a prevalent chronic esophageal disorder. Since the condition was first described, its pathophysiology has been known to have an immune-allergic origin, but the high response rate to dietary therapies based on feeding patients exclusively with amino acid-based elemental formula...

journal_title：Expert review of clinical immunology

authors： Arias A,Lucendo AJ

更新日期：2014-01-01 00:00:00

abstract：:Animal models and clinical studies of asthma have generated important insights into the first effector phase leading to the development of allergic airway disease and bronchial hyper-reactivity. In contrast, mechanisms related to asthma chronicity or persistence are less well understood. The CD4(+) T-helper 2 lymphocy...

journal_title：Expert review of clinical immunology

authors： Aronica MA,Vogel N

更新日期：2005-11-01 00:00:00

abstract：:Patients with systemic lupus erythematosus have a significantly increased risk of cardiovascular events due to atherosclerosis. Traditional cardiac risk factors cannot fully explain this increased risk. Recent evidence strongly suggests that atherosclerotic plaque is largely driven by inflammation and an active immuno...

journal_title：Expert review of clinical immunology

authors： McMahon M,Hahn BH,Skaggs BJ

更新日期：2011-03-01 00:00:00

abstract：:CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs) are an important regulatory innate cell population and have significant inhibitory effect on T cell-mediated responses. In addition to their negative role in cancer development, MDSCs also exert strong regulatory effects on transplantation and autoimmunity. In ma...

journal_title：Expert review of clinical immunology

authors： Wu T,Zhao Y,Zhao Y

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Remestemcel-L, a third-party, off-the-shelf preparation of bone-marrow derived mesenchymal stromal cells (MSCs), has been developed for experimental use in acute graft-versus-host disease (aGvHD) and other immune-mediated conditions. Several preclinical and clinical studies have indeed suggested the potent...

journal_title：Expert review of clinical immunology

authors： Locatelli F,Algeri M,Trevisan V,Bertaina A

更新日期：2017-01-01 00:00:00

abstract：:Introduction: While biologic agents that can be used for treating pemphigus vulgaris (PV) are increasing, themajority of the world's PV patients can afford only corticosteroids (CS) and some immunosuppressive agents (ISA). Areas covered: The spectrum of side effects encountered when PV patients receive high-dose, long...

journal_title：Expert review of clinical immunology

authors： Yanovsky RL,McLeod M,Ahmed AR

更新日期：2019-10-01 00:00:00

abstract：:Lung fibrosis is a devastating disease that involves a variable degree of inflammation, alveolar epithelial injury, fibroblast hyperplasia and the deposition of extracellular matrix. Standard therapies that consist of corticosteroids and immunosuppressive agents offer little benefit and most patients experience a prog...

journal_title：Expert review of clinical immunology

authors： Moore BB,Peters-Golden M

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Prediction of treatment outcome and clinical relapse in patients with inflammatory bowel disease (IBD), either ulcerative colitis (UC) or Crohn's disease (CD), is particularly important because therapeutics for IBD are not always effective and patients in remission could frequently relapse. Because undergo...

journal_title：Expert review of clinical immunology

authors： Kato J,Yoshida T,Hiraoka S

更新日期：2019-06-01 00:00:00

abstract：:Inflammatory bowel diseases share common pathogenetic mechanisms that are not yet completely understood. It is clear, however, that the expression and production of cytokines in response to inflammation plays a key role in mediating the migration of activated leukocytes. The process of angiogenesis and the expression ...

journal_title：Expert review of clinical immunology

authors： Fiorino G,Correale C,Fries W,Repici A,Malesci A,Danese S

更新日期：2010-07-01 00:00:00

abstract：:The past decade has been an exciting period for clinical research and patient care in rheumatoid arthritis. This is mostly due to targeted biologic agents that have changed the outcome of this disease. Certolizumab pegol (Cimzia(®), UCB Inc., GA, USA), which targets TNF-α with a different mechanism of action than wide...

journal_title：Expert review of clinical immunology

authors： Patel AM,Moreland LW

更新日期：2010-11-01 00:00:00

abstract：:Data generated using high-throughput DNA microarrays are changing the way we think about systemic lupus erythematosus (SLE). The identification of an interferon gene-expression signature in the majority of patients with SLE, especially those with severe SLE, has stimulated substantial interest in targeting the interfe...

journal_title：Expert review of clinical immunology

authors： Gaffney PM,Moser KL,Baechler EC

更新日期：2007-11-01 00:00:00