Future clinical implications emerging from recent genome-wide expression studies in asthma.

Abstract:

:Host susceptibility to environmental triggers is the most likely explanation for the development of asthma. Quantifying gene expression levels in disease-relevant tissues and cell types using fast evolving genomic technologies have generated new hypotheses about the pathogenesis of asthma and identified new therapeutic targets to treat asthma and asthma-exacerbations. New biomarkers and distinct transcriptomic phenotypes in blood, sputum and other tissues were also identified and proved effective to refine asthma classification and guide targeted therapies. The wealth of information provided by transcriptomic studies in asthma is yet to be fully exploited, but discoveries in this field may soon be implemented in clinical settings to improve diagnosis and treatment of patients afflicted with this common disease.

authors

Bérubé JC,Bossé Y

doi

10.1586/1744666X.2014.932249

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

985-1004

issue

8

eissn

1744-666X

issn

1744-8409

journal_volume

10

pub_type

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