Growth in children with adrenocortical tumors.

Abstract:

:Longitudinal growth was assessed in 10 children aged 0.8 to 11.8 years with adrenocortical tumors. All children had signs of androgen excess. In addition, 5 children had glucocorticoid excess, 1 child had estrogen excess. Multiple height recordings, expressed as height standard deviation score for chronological age, were available in 7 children. 5 patients in whom the tumor was successfully removed had postoperatively decreasing height standard deviation scores. 2 patients in whom tumor disease and hormone overproduction were not effectively controlled continued to show increased growth. When simultaneously present in one patient, the growth-promoting effects of androgen excess appear to override the growth-blocking properties of endogenous glucocorticoid excess. The importance of longitudinally recorded growth data for early diagnosis of an adrenocortical tumor is limited to those few children in whom hormone excess is given enough time to act on the skeleton before other tumor-related symptoms appear.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Hauffa BP,Roll C,Mühlenberg R,Havers W

doi

10.1055/s-2007-1025405

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

83-7

issue

2

eissn

0300-8630

issn

1439-3824

journal_volume

203

pub_type

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