Abstract:
INTRODUCTION:The objective of this study was to investigate the expression of matrix metalloproteinases (MMPs) in apical periodontitis and during the periapical healing phase after root canal treatment. METHODS:Apical periodontitis was induced in dog teeth, and root canal treatment was performed in a single visit or by using an additional calcium hydroxide root canal dressing. One hundred eighty days after treatment the presence of inflammation was examined, and tissues were stained to detect bacteria. Bacterial status was correlated to the degree of tissue organization, and to further investigate molecules involved in this process, tissues were stained for MMP-1, MMP-2, MMP-8, and MMP-9. Data were analyzed by using one-way analysis of variance followed by Tukey test or Kruskal-Wallis followed by Dunn test. RESULTS:Teeth with apical periodontitis that had root canal therapy performed in a single visit presented an intense inflammatory cell infiltrate. Periapical tissue was extremely disorganized, and this was correlated with the presence of bacteria. Higher MMP expression was evident, similar to teeth with untreated apical periodontitis. In contrast, teeth with apical periodontitis submitted to root canal treatment with calcium hydroxide presented a lower inflammatory cell infiltrate. This group had moderately organized connective tissue, lower prevalence of bacteria, and lower number of MMP-positive cells, similar to healthy teeth submitted to treatment. CONCLUSIONS:Teeth treated with calcium hydroxide root canal dressing exhibited a lower percentage of bacterial contamination, a lower MMP expression, and a more organized extracellular matrix, unlike those treated in a single visit. This suggests that calcium hydroxide might be beneficial in tissue repair processes.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Paula-Silva FW,da Silva LA,Kapila YLdoi
10.1016/j.joen.2009.10.030subject
Has Abstractpub_date
2010-02-01 00:00:00pages
231-7issue
2eissn
0099-2399issn
1878-3554pii
S0099-2399(09)00904-2journal_volume
36pub_type
杂志文章abstract::Regulated cell death (RCD) is a preferred term inclusive of all modes of cell death regulated by multiple intracellular signal transduction pathways under physiological and pathologic conditions. Although cell death programs ensure correct growth and developmental processes as well as protect the host against microbia...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2020.07.006
更新日期:2020-10-01 00:00:00
abstract::The 4- to 6-yr outcome of initial (first-time) endodontic treatment was assessed for Phase II of the "Toronto Study." In total, 442 teeth were treated by using flared preparation and vertical compaction of warm gutta-percha or step-back preparation and lateral compaction. With 126 teeth excluded (discontinuers: deceas...
journal_title:Journal of endodontics
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更新日期:2004-05-01 00:00:00
abstract:INTRODUCTION:The success of endodontic regeneration lies in the appropriate combination of stem cells and bioactive materials. Several novel dental materials are available on the market in this regard. Hence, the current study aimed to evaluate the proliferation, differentiation, and osteogenic potential of human bone ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.11.016
更新日期:2018-03-01 00:00:00
abstract::In the present study, we investigated the effect of the addition of different grades of gum rosins and hydrogenated resins to Grossman cement on dimensional stability, solubility and disintegration. pH and conductivity, which may affect these properties, were also determined. The experiments were performed according t...
journal_title:Journal of endodontics
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doi:10.1016/S0099-2399(99)80284-2
更新日期:1999-07-01 00:00:00
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journal_title:Journal of endodontics
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doi:10.1016/j.joen.2015.12.018
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:The inferior alveolar nerve (IAN) block does not always result in successful pulpal anesthesia. Anesthetic success rates might be affected by increased anxiety. Nitrous oxide has been shown to have both anxiolytic and analgesic properties. Therefore, the purpose of this prospective, randomized, double-blin...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2012.02.010
更新日期:2012-05-01 00:00:00
abstract::The apical sealing ability of amalgam, cold-burnished gutta-percha, amalgam with cavity varnish, and SuperEBA cement was evaluated in extracted human teeth. For each experimental group, the roots of 20 single-rooted teeth were sectioned from their crowns. Canals were cleaned, shaped, and obturated with vertically cond...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(89)80132-3
更新日期:1989-03-01 00:00:00
abstract::Advanced glycation end products (AGEs) have been found to play a role in inflammation and vascular complications. The receptor for AGE (RAGE) is expressed on many cells and is up-regulated during inflammation. To date, RAGE expression or its correlation with nuclear factor kappa beta (NF-kappabeta) expression has not ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.02.013
更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:The anatomy of the maxillary C-shaped molar has been the subject of several case reports although no true prevalence research has ever been conducted. The aim of this observational study was to evaluate and characterize the incidence of these morphologies using cone-beam computed tomographic (CBCT) technol...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.12.013
更新日期:2016-03-01 00:00:00
abstract::The role of T-cells in the development of periapical lesions was investigated immunohistochemically using 16 normal (BALB/c) mice and 16 nude (BALB/c nu/nu) mice (congenitally T-cell-deficient mice). The pulp chambers of maxillar first molars of all mice were opened, and the infiltrated immunocytes (anti-Thy1.2, -Lyt-...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/s0099-2399(06)80565-0
更新日期:1995-04-01 00:00:00
abstract:INTRODUCTION:Endodontic claims are the most frequently filed malpractice claims in dentistry. The aim of this study was to categorize and review errors and complications related to endodontic procedures that resulted in legal actions against the treating practitioner. METHODS:All dental malpractice complaints reported...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.03.030
更新日期:2010-06-01 00:00:00
abstract::This study compared the microshear bond strength of three resin-based sealers to root dentin and assessed whether sealer cements behave differently in thin and thick films. Extracted maxillary premolars were sectioned buccolingually, and 45 root halves were randomly allocated for microshear bond testing with the three...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.10.009
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the effect of nitrogen ion implantation on the flexibility of rotary nickel-titanium (NiTi) instruments as measured by the load required to bend implanted and nonimplanted instruments at a 30° angle. METHODS:Thirty K3 files, size #40, 0.02 taper and 25-mm length, were a...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.01.012
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:This clinical study was conducted to compare the levels of endotoxins (lipopolysaccharides [LPSs]) found in primary and secondary endodontic infections with apical periodontitis by correlating LPS contents with clinical/radiographic findings. In addition, the presence of target gram-negative anaerobic bact...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.04.021
更新日期:2012-08-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2005.07.007
更新日期:2006-06-01 00:00:00
abstract::An in vitro, flow-through optical system was designed to measure hemoglobin (Hb) concentrations in the pulp space. The system included light-emitting diodes and a silicon photodetector positioned on opposing surfaces of human teeth. A syringe pump allowed a controlled flow of blood through the pulp chamber. The Hb con...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80230-5
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to examine the effect of mineral trioxide aggregate (MTA) on pluripotent-mesenchymal cell differentiation. METHODS:The pluripotent-mesenchymal cell line C2C12 was cultured in a 5% serum medium to induce cell differentiation with or without MTA. The differentiation to myoblast...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.10.006
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The improvement of regenerative endodontic procedures requires an understanding of the key clinical questions combined with a fundamental biological knowledge of how the dental tissues behave during health, disease, and repair. Therefore, partnerships between clinicians and basic scientists are essential t...
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pub_type: 杂志文章,评审
doi:10.1016/j.joen.2020.06.019
更新日期:2020-09-01 00:00:00
abstract:INTRODUCTION:Patient preferences should be taken into account by clinicians when treatment planning. The purposes of this study were to describe the number of visits patients preferred when undergoing root canal therapy (RCT) and to assess whether their preferences were related to hypothetical treatment success rates. ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.06.038
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:This study compared the efficacy of a reciprocating single-instrument system and a rotary multi-instrument system followed by a supplementary approach with a finishing instrument in removing the filling material from curved canals during retreatment. METHODS:Forty mesial canals from extracted mandibular m...
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pub_type: 杂志文章
doi:10.1016/j.joen.2016.04.007
更新日期:2016-07-01 00:00:00
abstract::The aim of this in vivo study was to find a way to conduct qualitative and quantitative evaluations of radicular apical third apposition in rats. Twenty rats were injected intraperitoneally with tetracycline at weight-adjusted doses. Mesio-distal sections of the first mandibular molar regions were prepared. The 60 to ...
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pub_type: 杂志文章
doi:10.1016/S0099-2399(99)80153-8
更新日期:1999-04-01 00:00:00
abstract:INTRODUCTION:This study intended to evaluate the angiogenic properties of vital pulp therapy materials including white mineral trioxide aggregate (WMTA), calcium hydroxide (Ca[OH]2), Geristore (Den-Mat, Santa Maria, CA), and nano WMTA biomaterials. METHODS:WMTA, Ca(OH)2, Geristore, and nano WMTA disks were prepared, d...
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.06.003
更新日期:2013-10-01 00:00:00
abstract::The aim of this study was to determine the effects of patient's age on the prevalence and depth of bacterial penetration inside dentinal tubules. Fifty-six single-rooted teeth were divided in two groups based on the patient's age: young (ages 18-25) and old (age >or=60). Teeth were instrumented and inoculated with a s...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.10.004
更新日期:2009-01-01 00:00:00
abstract::A molar-incisor malformation (MIM) is a newly reported type of dental anomaly that involves a characteristic root malformation in permanent first molars and deciduous second molars and a crown defect in permanent central incisors. This case report describes a nonsurgical root canal treatment of a MIM-affected molar by...
journal_title:Journal of endodontics
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.09.022
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81292-6
更新日期:1993-11-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(89)80109-8
更新日期:1989-02-01 00:00:00
abstract::It is known that many factors participate in the process of inflammation and pain transmission. Recently, various neuropeptides have been demonstrated in the intrapulpal nerve fibers immunobiohistochemically. These neuropeptides may play some role in the process of inflammation and transmission of pain sensation. In t...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81566-9
更新日期:1990-02-01 00:00:00