Abstract：
INTRODUCTION:The improvement of regenerative endodontic procedures requires an understanding of the key clinical questions combined with a fundamental biological knowledge of how the dental tissues behave during health, disease, and repair. Therefore, partnerships between clinicians and basic scientists are essential to drive the field forward and improve patient outcomes. METHODS:This review aimed to provide a background to dentin-pulp biology and the interaction between infection, inflammation, and regeneration. RESULTS:We have highlighted how the release of neutrophil extracellular traps (NETs) within the pulp are double-edged; while they aim to limit the bacterial infection, they may actually exacerbate cell death and chronic inflammation. Aberrant levels of these structures may occur because of ineffective host immunologic processes, viral infections, or impaired clearance caused by bacterial virulence factors. We also postulate a proinflammatory link in the pulp between NETs and the inflammasome activated by pathogen-associated molecular patterns and damage-associated molecular patterns. Subsequently, we discuss areas potentially fruitful for future clinical exploitation involving NET inhibitors, inflammasome modulators, phototherapies, and novel epigenetic approaches. CONCLUSIONS:Sustained scientist-clinician research partnerships along with an increased understanding of the association between inflammation and regeneration within the dentin-pulp complex will lead to future patient benefit.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Duncan HF,Cooper PRdoi
10.1016/j.joen.2020.06.019subject
Has Abstractpub_date
2020-09-01 00:00:00pages
S10-S18issue
9Seissn
0099-2399issn
1878-3554pii
S0099-2399(20)30430-1journal_volume
46pub_type
杂志文章,评审abstract：INTRODUCTION:This case report describes the effect of unintentionally extruded mineral trioxide aggregate (MTA) into periradicular lesions and tissues on the prognosis of periradicular healing in maxillary left central incisor with periradicular lesion. METHODS:A 17-year-old girl with a large periradicular lesion from...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2009.11.026
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:The aims of this study were to evaluate the vertical and horizontal relationships between the maxillary sinus floor (MSF) and the root apices of maxillary posterior teeth with various root configurations and the distance from the root apex to the MSF and the buccal cortical plate. METHODS:Serial axial, co...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.08.011
更新日期：2015-11-01 00:00:00
abstract：:The extraoral sinus tract may occur as a result of an inflammatory process associated with a necrotic pulp. However, several non-odontogenic disorders may also produce an extraoral sinus tract. Thus, the differential diagnosis of this clinical finding is of paramount importance in providing appropriate clinical care b...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200312000-00015
更新日期：2003-12-01 00:00:00
abstract：:Irreversibly inflamed pulp (IIP) constitutes both a pathophysiologic and a diagnostic challenge. Gingival crevicular fluid (GCF) samples were obtained with Periopaper strips from IIP and adjacent and contralateral teeth for interleukin-8 (CXCL8) and tumor necrosis factor-alpha (TNF-alpha) measurements. Pain intensity ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2007.10.022
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:Endodontic diagnostic tests are often used clinically to assess pulp status as a basis for the diagnosis and determination of whether root canal treatment (RCT) is indicated. Response to cold and pain on percussion are 2 common tests, yet their validity in identifying nonvital pulp in regular dental practi...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.03.016
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess temperature changes in conventional gutta-percha, thermoplastic gutta-percha, and Resilon cones by using thermomechanical compaction technique. METHODS:The root canals of extracted human teeth were placed in resin blocks and sectioned. After root canal preparation, cavi...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2009.03.009
更新日期：2009-06-01 00:00:00
abstract：INTRODUCTION:The outcome of periapical surgery has been directly improved with the introduction of novel material formulations. The aim of the study was to compare the retrograde obturation quality of the following materials: calcium silicate (Biodentine; Septodont, Saint-Maur-des-Fosses, France), mineral trioxide aggr...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2017.09.022
更新日期：2018-05-01 00:00:00
abstract：:This report presents an unusual indication for root resection of a lower molar tooth and also reviews the history of root resection. ...
journal_title：Journal of endodontics
pub_type： 杂志文章,评审
doi：10.1097/00004770-200004000-00016
更新日期：2000-04-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of occlusal load on the integrity of root canal obturation. Maxillary anterior teeth were cleaned, shaped, and obturated with either gutta-percha (GP)/AH Plus or Resilon/Epiphany. Afterwards, teeth were placed under 100 N force at 2 Hz for 22 hours in a 37 degrees C...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.01.022
更新日期：2008-04-01 00:00:00
abstract：:Whole genome DNA-DNA hybridization has been used to identify bacteria in periradicular lesions partly because there is no amplification of the bacteria, therefore, minor contaminants are not detected. There are, however, potential pitfalls with this technique, including inability to distinguish dead bacteria, cross-re...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200407000-00014
更新日期：2004-07-01 00:00:00
abstract：:The purpose of this study was to evaluate a new periapical index based on cone beam computed tomography (CBCT) for identification of apical periodontitis (AP). The periapical index proposed in this study (CBCTPAI) was developed on the basis of criteria established from measurements corresponding to periapical radioluc...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.08.013
更新日期：2008-11-01 00:00:00
abstract：INTRODUCTION:Previously, we have shown that stem cells from apical papilla (SCAPs) can be chemoattracted by stromal cell-derived factor-1α (SDF-1α). The purpose of this study was to investigate the intracellular signaling pathways involved in SDF-1α-mediated migration of SCAPs. METHODS:Chemotaxis assays were performed...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.04.014
更新日期：2016-07-01 00:00:00
abstract：:The purpose of this study was to investigate histologically and histometrically the changes in pulpal and periapical tissues after pulpal exposure in rats. All animals received a pulpal exposure in the left mandibular first molar. Animals were killed at 1 to 56 days after pulpal exposure, and their mandibles were eval...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/s0099-2399(06)80020-8
更新日期：1994-01-01 00:00:00
abstract：:Analyses with the scanning electron microscope and the X-ray microprobe were performed on 13 silver cones removed from 12 patients. The cones showed changes that ranged from surface dulling to black corrosion and pitting. Sulfur and chlorine were detected at the apical end of the cones and in the biopsy specimens of p...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(75)80198-1
更新日期：1975-06-01 00:00:00
abstract：:Stem cell therapy is a potential strategy to regenerate the dentin-pulp complex, enabling the conservation and restoration of functional teeth. We assessed the efficacy and safety of pulp stem cell transplantation as a prelude before the initiation of clinical trials. Granulocyte-colony stimulating factor (G-CSF) indu...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.01.020
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:The anatomy of the maxillary C-shaped molar has been the subject of several case reports although no true prevalence research has ever been conducted. The aim of this observational study was to evaluate and characterize the incidence of these morphologies using cone-beam computed tomographic (CBCT) technol...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2015.12.013
更新日期：2016-03-01 00:00:00
abstract：:The objective of the present study was to investigate the presence of nine bacterial species in root-filled teeth associated with periapical lesions using a polymerase chain reaction analysis and to correlate these species with clinical features of the cases. DNA was extracted from 45 canal samples of root-filled teet...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2008.01.016
更新日期：2008-05-01 00:00:00
abstract：:Pulpitis, external root resorption, and pain may be experienced during orthodontic movement. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been suggested to control these changes. The purpose of this study was to observe pulp-dentinal reactions, root resorption, tooth pain, and tooth movement after the ...
journal_title：Journal of endodontics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.don.0000134212.20525.74
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:The aim of the present study was to assess the bond strength of root fillings in oval-shaped canals prepared with the self-adjusting file (SAF) system. METHODS:A careful specimen selection resulted in 2 equal groups, each consisting of 12 extracted mandibular canines with oval canals that had vital pulps ...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2012.10.026
更新日期：2013-02-01 00:00:00
abstract：:Enterococcus faecalis has been suggested to be an important etiological agent in endodontic failures. The purpose of this study was to evaluate the effectiveness of chlorhexidine- or antibiotics-based medications in eliminating E. faecalis biofilms. One-day and three-day biofilms of E. faecalis were induced on cellulo...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200110000-00004
更新日期：2001-10-01 00:00:00
abstract：INTRODUCTION:A 3-antibiotic combination (3Mix) has been widely used in regenerative endodontics. Recent studies recommend that a safe concentration of 3Mix is in the range of 0.39 μg/mL and 1 mg/mL because higher concentrations may limit tissue regeneration. The aim of this study was to determine the regenerative capac...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.09.027
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:Compelling evidence pinpoints that pulp tissue engineering after the transplantation of stem cells is possible. Although intriguing, severe problems regarding clinical feasibility remain. Cell homing has been proposed as a viable alternative in which dentin-derived growth factors in a conducive scaffold ma...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2018.02.011
更新日期：2018-06-01 00:00:00
abstract：:This case-control study sought to identify variables predictive of subsequent root canal therapy (RCT) in teeth receiving full coverage restorations. The University of North Carolina School of Dentistry's computerized treatment database was used to identify all patients receiving a single-unit crown on a nonendodontic...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2005.11.001
更新日期：2006-08-01 00:00:00
abstract：INTRODUCTION:The aim of this in vitro study was to compare the effectiveness of saline, 2.5% sodium hypochlorite, and 2% chlorhexidine, with or without passive ultrasonic irrigation (PUI), in debris removal from simulated canal irregularities within prepared root canals. METHODS:Ninety bovine lateral incisors were ran...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2014.08.006
更新日期：2014-12-01 00:00:00
abstract：INTRODUCTION:This study aimed to investigate the roles of ephrinB2 in stabilizing vascularlike structures generated by stem cells from apical papilla (SCAPs) and human umbilical vein endothelial cells (HUVECs). METHODS:HUVECs were seeded alone or with SCAPs concurrently or 12 hours later. Angiogenesis and ephrinB2 pho...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.05.012
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:The objective of this study was to compare the outcomes of initial nonsurgical root canal therapy for different tooth types provided by both endodontists and other providers. METHODS:By using an insurance company database, 487,476 initial nonsurgical root canal therapy procedures were followed from the ti...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2016.02.008
更新日期：2016-05-01 00:00:00
abstract：:The difference in resistance to bacterial invasion into the dentinal tubules between vital and nonvital teeth has not been determined. This study was conducted to clarify the effect of vital pulp on bacterial invasion into the dentinal tubules. The specimens were 19 intact pairs of bilateral upper third molars of 19 h...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/S0099-2399(06)81098-8
更新日期：1995-02-01 00:00:00
abstract：:A new endodontic obturation and retrofilling material has been invented to satisfy Grossman's requirements for an ideal material. Methylene blue dye leakage studies were carried out to compare the new material with conventional products, for both obturation and retrofilling. The experimental material when used in root...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1097/00004770-200207000-00008
更新日期：2002-07-01 00:00:00
abstract：INTRODUCTION:Cell migration is an important step in pulpal wound healing. Although components in the resin-based dental materials are known to have adverse effects on pulp wound healing including proliferation and mineralization, their effects on cell migration have been scarcely examined. Here, we investigated the eff...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2013.06.004
更新日期：2013-09-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to investigate the effects of pretreatment of gel chlorhexidine and ethanol on the bond strength and durability of the adhesion of the fiber post relined with resin composite to the root dentin. METHODS:Sixty bovine incisor roots were divided into four groups: irrigation with phy...
journal_title：Journal of endodontics
pub_type： 杂志文章
doi：10.1016/j.joen.2011.01.007
更新日期：2011-05-01 00:00:00
