Abstract:
INTRODUCTION AND AIMS:Chronic inflammation plays a major role in lung deterioration in cystic fibrosis (CF) patients and anti-inflammatory strategies have beneficial effects. To study the changes seen after a one-year course of low-dose dietary supplements with a mixture of fatty acids in adult patients with CF in chronic inflammation, pulmonary status (lung function, respiratory exacerbations and antibiotic consumption), quality of life and anthropometric parameters. PATIENTS AND METHOD:Seventeen adult subjects with CF received 324 mg of eicosapentaenoic, 216 mg of docosahexaenoic, 480 mg of linoleic and 258 mg of gammalinolenic acid daily. We assessed inflammation markers, spirometry parameters, number and severity of respiratory exacerbations, antibiotic consumption, quality of life (St George's QoL), anthropometric parameters and serum phospholipid fatty acid composition. RESULTS:At the end of the treatment period TNF alpha levels fell significantly and its soluble receptors (60 and 80) rose significantly. Levels of IgG and IgM anti-oxidized LDL antibodies fell significantly. Spirometry improved significantly. Annual respiratory exacerbations and days of antibiotic treatment fell significantly. The improvement in QoL was not significant. Serum levels of docosahexaenoic, total omega-3 and linoleic acid rose significantly and more favourable profiles were seen in monoenoic acids, arachidonic acid and the arachidonic/docosahexaenoic ratio. The fat-free mass and hand grip dynamometry improved significantly. CONCLUSIONS:Low-dose supplements of n-3 and gammalinolenic fatty acids over a long period (one year) appears to improve pulmonary status (lung function, respiratory exacerbations and antibiotic consumption), inflammatory and anthropometric parameters in adults with CF.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Olveira G,Olveira C,Acosta E,Espíldora F,Garrido-Sánchez L,García-Escobar E,Rojo-Martínez G,Gonzalo M,Soriguer Fdoi
10.1016/j.arbres.2009.11.001subject
Has Abstractpub_date
2010-02-01 00:00:00pages
70-7issue
2eissn
0300-2896issn
1579-2129pii
S0300-2896(09)00433-5journal_volume
46pub_type
临床试验,杂志文章abstract:INTRODUCTION:International and Spanish guidelines recommend a 4-drug regimen in the intensive treatment of tuberculosis (TB). The aim of our study was to determine if these recommendations are followed in Spain, and the factors associated with the use of 3 drugs (standard regimen without ethambutol). METHODOLOGY:Obser...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,多中心研究
doi:10.1016/j.arbres.2015.11.007
更新日期:2016-05-01 00:00:00
abstract::We report a patient with pneumonia and empyema secondary to an abdominal abscess due to Klebsiella pneumoniae from stones released into the abdominal cavity during laparoscopic cholecystectomy. ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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abstract:OBJECTIVE:Certain sporting activities may trigger asthma exacerbations of varying intensity in children. Such exacerbations may lead to limitations in and rejection of such activities. During school hours, teachers are in a good position to observe these phenomena. The aim of the present study was to evaluate the shutt...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60588-0
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abstract::A study was performed to assess differences in the clinical presentation of tuberculosis between two groups of immigrants. Ninety-four patients seen in the emergency room for newly diagnosed tuberculosis between 2006 and 2012 were included. Forty-nine patients were from Asian countries and 45 from Latin America. Mean ...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
abstract::Assessment of alpha 1-antitrypsin replacement therapy (AAT) for emphysema. Patient characteristics were analyzed along with the possible side effects of the treatment and its efficacy in maintaining appropriate AAT blood levels. Lung function changes were also studied. The treatment protocol began with 4 weekly intrav...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(15)30997-2
更新日期:1994-12-01 00:00:00
abstract::This case report describes two patients admitted to our hospital for elective surgery, one for biliary disease and the other for vascular disease. Shortly after surgery each presented a clinical picture attributable to membranous tracheal pars rupture caused by anesthetic intubation. Airway lesions were diagnosed and,...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
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更新日期:1997-03-01 00:00:00
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abstract:INTRODUCTION:Few studies have examined the 24-hour symptom profile in patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to determine daily variations in the symptoms of patients with stable COPD in Spain, compared with other European countries. METHODS:Observational study...
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pub_type: 杂志文章,多中心研究
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更新日期:2016-06-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2019.10.015
更新日期:2020-08-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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journal_title:Archivos de bronconeumologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0300-2896(03)75452-0
更新日期:2003-12-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
doi:10.1016/s1579-2129(06)60124-9
更新日期:2006-02-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2019.12.033
更新日期:2020-02-29 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60400-x
更新日期:2005-02-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/j.arbres.2020.07.024
更新日期:2021-01-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.arbres.2015.07.017
更新日期:2016-01-01 00:00:00
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doi:10.1016/j.arbres.2010.06.013
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
doi:10.1016/s0300-2896(15)31145-5
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pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60426-6
更新日期:2005-04-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 杂志文章,评审
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更新日期:1994-04-01 00:00:00
abstract::We proposed to search for markers of hypercoagulable states in function of age, sex or factors that trigger venous thromboembolic disease (VTD) in a group of patients so diagnosed. The following patient data were analyzed: age, sex and triggering factors of VTD categorized as associative-transient, permanent or unknow...
journal_title:Archivos de bronconeumologia
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Archivos de bronconeumologia
pub_type: 临床试验,杂志文章
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1579-2129(06)60331-5
更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.arbres.2014.04.007
更新日期:2015-01-01 00:00:00