The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples.

abstract：:Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that pa...

journal_title：Thrombosis and haemostasis

authors： Salomon O,Steinberg DM,Zucker M,Varon D,Zivelin A,Seligsohn U

更新日期：2011-02-01 00:00:00

abstract：:One of the most severe and important complication in the treatment of haemophilia A (HA) patients is the formation of inhibitors. The mechanism that leads to factor (F)VIII inhibitor formation is complicated. Both genetic and environmental factors have been mentioned to play decisive roles. Recently, polymorphisms in ...

journal_title：Thrombosis and haemostasis

authors： Lu Y,Ding Q,Dai J,Wang H,Wang X

更新日期：2012-01-01 00:00:00

abstract：:In trauma patients, resuscitation treatment of intravascular volume may cause haemodilution including blood cell- and plasma-dilution. After plasma-dilution, fibrinogen is the first factor that decreases to critically low concentrations. Fibrin formed in lowered levels is susceptible to fibrinolysis, a natural forerun...

journal_title：Thrombosis and haemostasis

authors： He S,Johnsson H,Zabczyk M,Hultenby K,Wallén H,Blombäck M

更新日期：2014-03-03 00:00:00

abstract：:Inherited thrombophilia has been shown to be linked with fetal loss. We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian women. A total of 348 wome...

journal_title：Thrombosis and haemostasis

authors： Zammiti W,Mtiraoui N,Mercier E,Abboud N,Saidi S,Mahjoub T,Almawi WY,Gris JC

更新日期：2006-04-01 00:00:00

abstract：:In vitro and in vivo effects of adrenaline (ADR) on platelet aggregation, on platelet factor 3 (PF3) availability and on platelet factor 4 (PF4) release were studied in man. Inhibitory action of an alpha-blocker, phentolamine (PHEN) was investigated in the same conditions. The threshold concentration (TC) of ADR induc...

journal_title：Thrombosis and haemostasis

authors： Ponari O,Civardi E,Megha A,Pini M,Poti' R,Dettori AG

更新日期：1978-10-31 00:00:00

abstract：:Serum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal ph...

journal_title：Thrombosis and haemostasis

authors： Fiedel BA,Ku CS

更新日期：1986-06-30 00:00:00

abstract：:Sixty-four Chinese women were studied for the effects of injecting once-a-month contraceptive norethisterone enanthate/estradiol valerate between 2 to 4 1/2 years on certain coagulation and fibrinolytic parameters, and 59 women not receiving any steroidal contraception were controls. In both groups there was no signif...

journal_title：Thrombosis and haemostasis

authors： Meng YX,Jiang HY,Lu FY

更新日期：1990-12-28 00:00:00

abstract：:The effects of etamsylate on human platelet aggregation and ATP release as well as on the arachidonate metabolism by the platelet have been studied. Etamsylate enhanced these platelet functions induced by arachidonic acid (AA), thromboxane A2, collagen and calcium ionophore A23187 but not those induced by ADP and epin...

journal_title：Thrombosis and haemostasis

authors： Okuma M,Takayama H,Sugiyama T,Sensaki S,Uchino H

更新日期：1982-12-27 00:00:00

abstract：:It is known that thrombosis is a leading cause of vascular access failure and that the formation of thrombus requires platelets. The activation of platelets induces the increase in intracellular Ca 2(+) levels ([Ca(2+)](i)) leading to aggregation and thrombosis. We compared the platelet [Ca(2+)](i) before and after st...

journal_title：Thrombosis and haemostasis

authors： Chou KJ,Jan CR,Lee PT,Chen CL,Chung HM,Hwang YY,Chou JD,Fang HC

更新日期：2004-09-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer developme...

journal_title：Thrombosis and haemostasis

authors： Asare Y,Schmitt M,Bernhagen J

更新日期：2013-03-01 00:00:00

abstract：:Fibrinogen Matsumoto V (M-V) is a dysfibrinogen identified in a 52-year-old woman with systemic lupus erythematous. The triplet AGG encoding the amino acid residue Aalpha19 was replaced by GGG, resulting in the substitution of Arg-->Gly. Residue Aalpha19 has been shown to be one of the most important amino acids in th...

journal_title：Thrombosis and haemostasis

authors： Tanaka H,Terasawa F,Ito T,Tokunaga S,Ishida F,Kitano K,Kiyosawa K,Okumura N

更新日期：2001-01-01 00:00:00

abstract：:Pharmaceutical grade heparins from porcine intestine and bovine lung consist mainly of repeating tri-sulfated units, of the disaccharide →4-α-IdoA2S-1→4-α-GlcNS6S-1→. Heparin preparations from bovine intestine, in contrast, are more heterogeneous. Nuclear magnetic resonance (NMR) and disaccharide analysis after hepari...

journal_title：Thrombosis and haemostasis

authors： Tovar AM,Capillé NV,Santos GR,Vairo BC,Oliveira SN,Fonseca RJ,Mourão PA

更新日期：2012-05-01 00:00:00

abstract：:Thirty-one individuals from 18 unrelated families with antithrombin deficiency have been identified as having a single point mutation within codon 384 (13268 GCA-->TCA) resulting in an alanine to serine substitution. Six families (11 individuals) were identified by the screening of individuals with thromboembolic dise...

journal_title：Thrombosis and haemostasis

authors： Perry DJ,Daly ME,Tait RC,Walker ID,Brown K,Beauchamp NJ,Preston FE,Gyde H,Harper PL,Carrell RW

更新日期：1998-02-01 00:00:00

abstract：:Three single nucleotide polymorphisms (-603A/G, -1322C/T, -1812C/T) and one deletion/insertion polymorphism (-1208D/I) are present in the tissue factor (TF) gene promoter sequence. These polymorphisms are in complete linkage disequilibrium, determining two haplotypes with almost equal frequency. The -603A/-1208D/-1322...

journal_title：Thrombosis and haemostasis

authors： Reny JL,Laurendeau I,Fontana P,Bièche I,Dupont A,Remones V,Emmerich J,Vidaud M,Aiach M,Gaussem P

更新日期：2004-02-01 00:00:00

abstract：:Bernard-Soulier syndrome (BSS) is an autosomal recessive bleeding disorder due to quantitative or qualitative abnormalities in the glycoprotein (GP) Ib/IX/V complex, the platelet receptor for von Willebrand factor. This complex is composed of four subunits, GPIbalpha, GPIbbeta, GPIX and GPV. We describe here the genet...

journal_title：Thrombosis and haemostasis

authors： Kunishima S,Tomiyama Y,Honda S,Fukunishi M,Hara J,Inoue C,Kamiya T,Saito H

更新日期：2000-07-01 00:00:00

abstract：:A procedure for using citrated fresh plasmas for International Sensitivity Index (ISI) calibration of two types of whole blood point-of-care test (POCT) prothrombin time (PT) monitor systems has been assessed in a multicentre study. The CoaguChek Mini and TAS PT-NC systems gave higher ISI with whole blood samples than...

journal_title：Thrombosis and haemostasis

authors： Poller L,Keown M,Chauhan N,van den Besselaar AM,Tripodi A,Shiach C,Jespersen J,European Concerted Action on Anticoagulation Steering Group Members.

更新日期：2002-05-01 00:00:00

abstract：:Monitoring of anti-factor Xa activity is often performed during treatment with low-molecular-weight heparins (LMWHs) in pregnancy because the anticoagulant effect may decrease as pregnancy progresses, but assays for anti-factor Xa activity are unavailable in many clinical institutions caring for pregnant women. Heptes...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Zharkowa U,Elmas E,Ahmad-Nejad P,Neumaier M,Borggrefe M

更新日期：2009-11-01 00:00:00

abstract：:Prothrombin complex concentrates (PCC) are known to carry a risk of thromboembolism. We have chosen to reassess the problem of detecting in vivo signs of activation of the clotting mechanism by assaying fibrinopeptide A (FpA) after PCC administration in hemophilic patients during bleeding episodes. FpA was significant...

journal_title：Thrombosis and haemostasis

authors： Viganó S,Cattaneo M,Gervasoni W,Mannucci PM

更新日期：1980-10-31 00:00:00

abstract：:Increased liver fat may be caused by insulin resistance and adipose tissue inflammation or by the common I148M variant in PNPLA3 at rs738409, which lacks both of these features. We hypothesised that obesity/insulin resistance rather than liver fat increases circulating coagulation factor activities. We measured plasma...

journal_title：Thrombosis and haemostasis

authors： Lallukka S,Luukkonen PK,Zhou Y,Isokuortti E,Leivonen M,Juuti A,Hakkarainen A,Orho-Melander M,Lundbom N,Olkkonen VM,Lassila R,Yki-Järvinen H

更新日期：2017-01-26 00:00:00

abstract：:Developmental haemostasis is a concept, now universally accepted, introduced by Andrew et al. in the late 1980's. However, coagulation analysers and reagents have changed significantly over the past 15 years. Coagulation testing is known to be sensitive to changes in individual reagents and analysers. We hypothesised ...

journal_title：Thrombosis and haemostasis

authors： Monagle P,Barnes C,Ignjatovic V,Furmedge J,Newall F,Chan A,De Rosa L,Hamilton S,Ragg P,Robinson S,Auldist A,Crock C,Roy N,Rowlands S

更新日期：2006-02-01 00:00:00

abstract：:Recent meta-analyses indicate that low molecular weight heparins (LMWH) are more effective than unfractionated heparin (UH) in preventing and treating deep vein thrombosis. This article presents the arguments for and against the need for laboratory monitoring. At the present time, the only tests currently available fo...

journal_title：Thrombosis and haemostasis

authors： Boneu B

更新日期：1994-09-01 00:00:00

abstract：:Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor V(Leiden) (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns. Pregnant women with known thrombophilia (n=27) were enro...

journal_title：Thrombosis and haemostasis

authors： Hyytiäinen S,Wartiovaara-Kautto U,Ulander VM,Kaaja R,Heikinheimo M,Petäjä J

更新日期：2006-03-01 00:00:00

abstract：:Catheter-directed thrombolysis has gained increasing acceptance for the treatment of patients who present with vascular occlusion; however, intravenous injection may be preferable in selected patients. Recombinant prourokinase (r-proUK) is a recently-developed fibrin-selective thrombolytic agent with specificity for c...

journal_title：Thrombosis and haemostasis

authors： Burke SE,Lubbers NL,Nelson RA,Wegner CD,Cox BF

更新日期：1999-02-01 00:00:00

abstract：:The gel-chromatography of the beta-alanine precipitate of human plasma and of purified fibrinogen shows the presence of different classes of fibrinogen complexes. A first class of complexes is detectable in correspondence with the ascending branch of the fibrinogen peak ("shoulder" complexes or high molecular weight f...

journal_title：Thrombosis and haemostasis

authors： Serneri GGE,Gensini GF,Abbate R,Favilla S

更新日期：1979-07-01 00:00:00

abstract：:Following the initial report of the clinical use of plasminogen activators (PAs) in cerebrovascular thrombosis in 1958, interest in the efficacy of this approach accelerated only when the need for acute intervention in stroke was recognized. The use of PAs in acute ischemic stroke is based on the observation that appr...

journal_title：Thrombosis and haemostasis

authors： del Zoppo GJ

更新日期：1997-07-01 00:00:00

abstract：:The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg-1 min-1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind ...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wiman B,Olsson G,Angelin B,Hjemdahl P

更新日期：1990-06-28 00:00:00

abstract：:The vast clinical research programme for the direct, oral factor Xa inhibitor rivaroxaban has generated a wealth of data since the first rivaroxaban approval in 2008 for the prevention of venous thromboembolism (VTE) in patients undergoing elective hip or knee replacement surgery. While rivaroxaban is widely used acro...

journal_title：Thrombosis and haemostasis

authors： Cappato R,Welsh R

更新日期：2016-09-28 00:00:00

abstract：:In 7 healthy volunteers, formation of thrombin (represented by fibrinopeptide A (FPA) generation, alpha-granule release (represented by beta-thromboglobulin [beta TG] release) and the generation of thromboxane B2 (TxB2) were measured in vivo in blood emerging from a template bleeding time incision. At the site of plug...

journal_title：Thrombosis and haemostasis

authors： Kyrle PA,Westwick J,Scully MF,Kakkar VV,Lewis GP

更新日期：1987-02-03 00:00:00

abstract：:Several members of a family from Scranton, Pennsylvania were identified to have normal levels of prothrombin antigen while their prothrombin clotting activity was approximately 50% of normal. There has been no previous history of bleeding or other clinical manifestations in this family. The genomic DNA from the proban...

journal_title：Thrombosis and haemostasis

authors： Sun WY,Smirnow D,Jenkins ML,Degen SJ

更新日期：2001-04-01 00:00:00

abstract：:The effect of additional treatments combined with conventional therapy on pregnancy outcomes was examined in high-risk primary antiphospholipid syndrome (PAPS) patients to identify the most effective treatment strategy. The study's inclusion criteria were (1) positivity to lupus anticoagulant alone or associated with ...

journal_title：Thrombosis and haemostasis

authors： Ruffatti A,Tonello M,Hoxha A,Sciascia S,Cuadrado MJ,Latino JO,Udry S,Reshetnyak T,Costedoat-Chalumeau N,Morel N,Marozio L,Tincani A,Andreoli L,Haladyj E,Meroni PL,Gerosa M,Alijotas-Reig J,Tenti S,Mayer-Pickel K,Simc

更新日期：2018-04-01 00:00:00