Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin.

abstract：:Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) were measured alongside flow-mediated vasodilation (FMD) in 34 patients with intermittent claudication and 14 control subjects. Patients with plasma sICAM-1 >253 ng/mL (median value) showed lower FMD than those with...

journal_title：Thrombosis and haemostasis

authors： Brevetti G,Martone VD,de Cristofaro T,Corrado S,Silvestro A,Di Donato AM,Bucur R,Scopacasa F

更新日期：2001-01-01 00:00:00

abstract：:Activated protein C resistance is in almost all cases caused by the factor V Leiden mutation (FV:R506Q). Due to the high prevalence and clinical significance of the mutation reliable methods suited for processing large sets of samples are in demand. We here present the oligonucleotide ligation assay (OLA) with lanthan...

journal_title：Thrombosis and haemostasis

authors： Chakravarty A,Hansen TS,Hørder M,Kristensen SR

更新日期：1997-10-01 00:00:00

abstract：:The effects of human activated protein C (APC) and thrombin on plasminogen activator inhibitor (PAI-1) released from cultured human umbilical endothelial cells, grown in serum-free 35S-methionine containing medium, were studied in two ways: measurement of PAI-1 activity with an amidolytic assay, and immunoprecipitatio...

journal_title：Thrombosis and haemostasis

authors： de Fouw NJ,van Hinsbergh VW,de Jong YF,Haverkate F,Bertina RM

更新日期：1987-04-07 00:00:00

abstract：:Platelets and coagulation are involved in bacterial colonisation of the host. Streptocococcus pneumoniae (pneumococcus) are important etiologic agents of respiratory tract infections in humans. The formation of pneumococci-platelet associations may facilitate haematogenous dissemination of pneumococci by providing an ...

journal_title：Thrombosis and haemostasis

authors： Niemann S,Kehrel BE,Heilmann C,Rennemeier C,Peters G,Hammerschmidt S

更新日期：2009-10-01 00:00:00

abstract：:Factor VII is a vitamin K-dependent zymogen that plays a key role in the initiation of the extrinsic pathway. A severe factor VII deficiency was identified in a 45-year old male whose plasma factor VII antigen was less than 60 ng/ml and expressed 5.2% of normal factor VII activity. DNA sequence analysis of the patient...

journal_title：Thrombosis and haemostasis

authors： Katsumi A,Matsushita T,Yamazaki T,Sugiura I,Kojima T,Saito H

更新日期：2000-02-01 00:00:00

abstract：:Restenosis following successful percutaneous coronary revascularization continues to represent a major problem limiting the clinical efficacy of this procedure. The underlying mechanisms of restenosis are comprised of a combination of effects from vessel recoil, negative vascular remodeling, thrombus formation and neo...

journal_title：Thrombosis and haemostasis

authors： Rosanio S,Tocchi M,Patterson C,Runge MS

更新日期：1999-09-01 00:00:00

abstract：:Forty-two patients with total occlusion of a coronary vessel were treated with intracoronary fibrinolytic agents. Four therapeutic protocols were compared: group I received streptokinase (SK) as a continuous infusion; group II and III received SK as a bolus at different doses and group IV received lysplasminogen (Pg) ...

journal_title：Thrombosis and haemostasis

authors： de Prost D,Guerot C,Laffay N,Horellou MH,Samama M

更新日期：1983-12-30 00:00:00

abstract：:We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3,000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprote...

journal_title：Thrombosis and haemostasis

authors： Bolibar I,von Eckardstein A,Assmann G,Thompson S,ECAT Angina Pectoris Study Group. European Concerted Action on Thrombosis and Disabilities.

更新日期：2000-12-01 00:00:00

abstract：:To study the effect of lymphocyte adhesion on the procoagulant activity of endothelial cells, we have stimulated HUVECs with interferon-gamma to upregulate adhesion molecules. Subsequent addition of lymphocytes induced the expression of tissue factor (TF) by HUVECs. Both CD4+ and CD8+ T-cells promoted this TF synthesi...

journal_title：Thrombosis and haemostasis

authors： Schmid E,Müller TH,Budzinski RM,Pfizenmaier K,Binder K

更新日期：1995-03-01 00:00:00

abstract：:Prevention of a secondary response to factor IX by cyclophosphamide was attempted in an 11 year old patient with severe Christmas disease. An antibody to factor IX had been present for 4 years before immunosuppressive therapy was tried. Despite profound lymphopenia, synthesis of factor IX antibody was not depressed. T...

journal_title：Thrombosis and haemostasis

authors： Allain JP,Frommel D

更新日期：1976-08-31 00:00:00

abstract：:We tested different types of clot for their ability to provoke procoagulant activity in platelets: normal clots from platelet poor plasma (des AABB- or fibrin II clots), similar clots in which the adsorbed thrombin has been inhibited by hirudin, and clots obtained by the action of two snake venom enzymes that release ...

journal_title：Thrombosis and haemostasis

authors： Kumar R,Béguin S,Hemker HC

更新日期：1995-09-01 00:00:00

abstract：:Twenty-nine of 54 uremic patients had low levels of protein C measured as anticoagulant activity, contrasting with normal levels measured as amidolytic activity or antigenic concentration. We demonstrate that this discrepancy is due to the presence of a soluble plasma inhibitor that interferes specifically with the an...

journal_title：Thrombosis and haemostasis

authors： Faioni EM,Franchi F,Krachmalnicoff A,Valsecchi C,Viganò GL,Remuzzi G,Mannucci PM

更新日期：1991-10-01 00:00:00

abstract：:During treatment with vitamin K antagonists, International Normalized Ratios (INR) are determined periodically to maintain a therapeutic level of anticoagulation. We evaluated two existing methods for therapeutic quality control (linear interpolation and equidivision), with regard to their validity and reproducibility...

journal_title：Thrombosis and haemostasis

authors： Hutten BA,Prins MH,Redekop WK,Tijssen JG,Heisterkamp SH,Büller HR

更新日期：1999-10-01 00:00:00

abstract：:Individuals with lupus anticoagulants (LA) are at risk for thromboembolism (TE). Chronic inflammation is an important characteristic in LA patients which may dispose for TE. Platelets play a key role in inflammation and TE. We therefore investigated gene polymorphisms as well as plasma levels of platelet receptors as ...

journal_title：Thrombosis and haemostasis

authors： Bugert P,Pabinger I,Stamer K,Vormittag R,Skeate RC,Wahi MM,Panzer S

更新日期：2007-04-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

journal_title：Thrombosis and haemostasis

authors： Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

更新日期：2019-05-01 00:00:00

abstract：:Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

journal_title：Thrombosis and haemostasis

authors： Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

更新日期：1991-12-02 00:00:00

abstract：:In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation facto...

journal_title：Thrombosis and haemostasis

authors： Balleisen L,Assmann G,Bailey J,Epping PH,Schulte H,van de Loo J

更新日期：1985-10-30 00:00:00

abstract：:Subcutaneous heparin is the treatment of choice for women requiring anticoagulant therapy during pregnancy. However, heparin therapy presents a management problem at delivery because of its potential to cause a persistent anticoagulant effect and thus increase the risk of bleeding. In order to avoid therapeutic compli...

journal_title：Thrombosis and haemostasis

authors： Anderson DR,Ginsberg JS,Burrows R,Brill-Edwards P

更新日期：1991-03-04 00:00:00

abstract：:The generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen...

journal_title：Thrombosis and haemostasis

authors： Koppensteiner R,Speiser W,Minar E,Ahmadi R,Ehringer H

更新日期：1990-10-22 00:00:00

abstract：:Early treatment of disseminated intravascular coagulation (DIC) is recommended but global coagulation tests used in authorized DIC criteria are not sensitive for diagnosis of early-phase DIC. We examined the plasma levels of thrombin-antithrombin complex (TAT), plasmin-plasmin inhibitor complex (PPIC) and D-dimer in p...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Wada H,Okamoto K,Iba T,Uchiyama T,Eguchi Y,Kawasugi K,Koga S,Mayumi T,Koike K,Gando S

更新日期：2006-02-01 00:00:00

abstract：:Membrane-permeable 8-(4-chlorophenylthio)-2'-O-methyl cyclic AMP (8-pCPT-2'-O-Me-cAMP) has been shown to specifically activate cAMP-regulated Epac proteins, without direct effects on protein kinase A and protein kinase G. During isometric tension measurements in thoracic aortic rings from Wistar rats, we observed that...

journal_title：Thrombosis and haemostasis

authors： Sand C,Grandoch M,Börgermann C,Oude Weernink PA,Mahlke Y,Schwindenhammer B,Weber AA,Fischer JW,Jakobs KH,Schmidt M

更新日期：2010-03-01 00:00:00

abstract：:Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis. Therefore, inhibition of the CD40-CD40L pathway is an attractive therapeutic target to reduce clinical complications of atherosclerosis. The C...

journal_title：Thrombosis and haemostasis

authors： Lievens D,Eijgelaar WJ,Biessen EA,Daemen MJ,Lutgens E

更新日期：2009-08-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen (HK) and cleaved HK (HKa) both interact with at least three endothelial cell binding proteins: urokinase plasminogen activator receptor (uPAR), globular C1q re...

journal_title：Thrombosis and haemostasis

authors： Pixley RA,Espinola RG,Ghebrehiwet B,Joseph K,Kao A,Bdeir K,Cines DB,Colman RW

更新日期：2011-06-01 00:00:00

abstract：:Homozygous carriers of factor V Leiden have an approximately 80-fold increased risk of venous thrombosis. Also double heterozygous carriers of both the factor V Leiden and the prothrombin gene mutations are at high thrombotic risk. The magnitude of the risk of venous thrombosis in pregnant women with the two severe th...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Legnani C,Bucciarelli P,Grandone E,De Stefano V,Mannucci PM

更新日期：2001-09-01 00:00:00

abstract：:Patients with atrial fibrillation at moderate to high risk of stroke are not always anticoagulated despite a lack of contraindications to vitamin K antagonists (VKAs) like warfarin. These patients are treated with aspirin, aspirin-clopidogrel combination therapy or even receive no thromboprophylaxis. The oral direct t...

journal_title：Thrombosis and haemostasis

authors： Roskell NS,Lip GY,Noack H,Clemens A,Plumb JM

更新日期：2010-12-01 00:00:00

abstract：:We investigated the molecular basis for factor VII (FVII) deficiency in Israel and found that 13 patients were homozygous and 10 heterozygous for a C to T substitution at nucleotide 10648 of the FVII gene. This predicted an Ala244Val change and was associated with decreased FVII activity and antigen level. Of the 36 A...

journal_title：Thrombosis and haemostasis

authors： Tamary H,Fromovich Y,Shalmon L,Reich Z,Dym O,Lanir N,Brenner B,Paz M,Luder AS,Blau O,Korostishevsky M,Zaizov R,Seligsohn U

更新日期：1996-09-01 00:00:00

abstract：:It was the aim of the present study to perform a systematic review of the published studies that estimated the prevalence of non-responders to aspirin, as assessed by the closure time of PFA-100, a point-of-care device, and to analyse: 1) some major clinical and methodological factors that can influence it and 2) its ...

journal_title：Thrombosis and haemostasis

authors： Crescente M,Di Castelnuovo A,Iacoviello L,Vermylen J,Cerletti C,de Gaetano G

更新日期：2008-01-01 00:00:00

abstract：:In hereditary angioedema (HAE), normal C1-inhibitor (C1-INH) is low and the contact system activated. Recently, the findings of a tissue factor mutant selectively deficient in promoting the conversion of FVII to FVIIa, but with retained cofactor for FVIIa, made it possible to examine reliably the pre-existing content ...

journal_title：Thrombosis and haemostasis

authors： Nielsen EW,Morrissey J,Olsen JO,Osterud B

更新日期：1995-10-01 00:00:00

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00