[Evidence-based medicine and therapeutic ultrasound of the musculoskeletal system].

abstract：AIM:The present study should elucidate the efficacy, patient acceptability, and side effect profiles of Oxaprozin and Diclofenac retard when given to patients with active primary osteoarthrosis. METHODS:80 outpatients with active primary osteoarthrosis with a radiological grade of II or III in the hip or knee joint (m...

journal_title：Zeitschrift fur Rheumatologie

authors： Karbowski A,Schwitalle M,Eckardt A

更新日期：1998-04-01 00:00:00

abstract：:Osteoporosis is an age-related systemic disease leading to increased bone fragility. The vertebral bodies of the transitional area between the thoracic and lumbar spine are often involved. A large number of unreported or late-diagnosed fractures have to be assumed. If risk factors such as advanced age or comorbidities...

journal_title：Zeitschrift fur Rheumatologie

authors： Boluki D

更新日期：2011-01-01 00:00:00

abstract：:Big data analysis raises the expectation that computerized algorithms may extract new knowledge from otherwise unmanageable vast data sets. What are the algorithms behind the big data discussion? In principle, high throughput technologies in molecular research already introduced big data and the development and applic...

journal_title：Zeitschrift fur Rheumatologie

authors： Bonin-Andresen M,Smiljanovic B,Stuhlmüller B,Sörensen T,Grützkau A,Häupl T

更新日期：2018-04-01 00:00:00

abstract：:A set of early diagnostic (ED) criteria comprising clinical data, ESR, radiological spinal signs, and the risk factor HLA B27 was evaluated after 5 and 10 years in a follow-up of 54 patients with an initial diagnosis of possible ankylosing spondylitis (AS). After 10 years 32 patients (59%) had developed definite AS ac...

journal_title：Zeitschrift fur Rheumatologie

authors： Mau W,Zeidler H,Mau R,Majewski A,Freyschmidt J,Stangel W,Deicher H

更新日期：1990-03-01 00:00:00

abstract：:In the last years some important therapies were introduced in the treatment of rheumatoid arthritis (RA), which represent a significant clinical advance. This concerns the introduction of TNF blockade with etanercept and inflixmab, the combination of DMARDs, leflunomide and the COX-2-specific inhibitors. In the year 2...

journal_title：Zeitschrift fur Rheumatologie

authors： Edelmann E

更新日期：2001-12-01 00:00:00

abstract：:Seronegative rheumatoid arthritis (RA) patients have increased proportions of OKT-4+ (helper) T cells and diminished proportions of OKT-8+ (suppressor/cytotoxic) T cells in the peripheral blood. This phenomenon corresponds to diminished inhibition of B cell activation by peripheral blood lymphocytes (PBL). Seropositiv...

journal_title：Zeitschrift fur Rheumatologie

authors： Lemm G,Warnatz H

更新日期：1984-05-01 00:00:00

abstract：:The effect of D-penicillamine, given for 14 days in doses of 100 mg/kg and 225 mg/kg, upon the collagen metabolism of skin and bone tissues was studied in rats. The smaller dosage of D-penicillamine did not effect the collagen synthesis in skin or bone. When the higher dosage was used, however, an increase of collagen...

journal_title：Zeitschrift fur Rheumatologie

authors： Trnavská Z,Trnavský K

更新日期：1977-05-01 00:00:00

abstract：:The SAPHO syndrome, an acronym for synovitis, acne, pustulosis, hyperostosis and osteitis, is a rare disease which affects bones, joints and the skin. The main osteoarticular features are hyperostosis and osteitis. Osteoarticular symptoms predominantly occur on the anterior chest wall but the spine and the peripheral ...

journal_title：Zeitschrift fur Rheumatologie

authors： Heldmann F,Kiltz U,Baraliakos X,Braun J

更新日期：2014-10-01 00:00:00

abstract：:A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observati...

journal_title：Zeitschrift fur Rheumatologie

authors： Straub RH,Schölmerich J,Zietz B

更新日期：2000-01-01 00:00:00

abstract：:A 28-year-old female patient had load-dependent pain of the left knee. MRI showed an osteochondral defect of the medial condyle based on extensive osteonecrosis of the femoral and tibial bone. An association with a prior steroid treatment after cervical injury is most likely. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Steinhagen J,Rüther W

更新日期：2004-06-01 00:00:00

abstract：:Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by, among other things, spinal and extraspinal manifestations. Two studies on the prevalence and clinical significance of hyperostotic spurs and ectopic ossifications in the pelvic area are presented. Spinal DISH seems to be a risk factor for the develop...

journal_title：Zeitschrift fur Rheumatologie

authors： Fahrer H,Koch P,Barandun R,Gerber NJ

更新日期：1988-07-01 00:00:00

abstract：:A few days after the SARS-CoV-2 infection was declared a pandemic, the German Society for Rheumatology (DGRh) compiled first recommendations for the care of patients with inflammatory rheumatic diseases (IRD). These first recommendations were based on an expert consensus and were largely non-evidence-based. Now that t...

journal_title：Zeitschrift fur Rheumatologie

authors： Schulze-Koops H,Iking-Konert C,Leipe J,Hoyer BF,Holle J,Moosig F,Aries P,Burmester G,Fiehn C,Krause A,Lorenz HM,Schneider M,Sewerin P,Voormann A,Wagner U,Krüger K,Specker C,Kommission Pharmakotherapie.,Vorstand der De

更新日期：2020-09-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with a shortened life expectancy. Most premature deaths are caused by cardiovascular (CV) events; therefore it is of importance to consider the increased CV risk when treating RA patients. Traditional CV risk factors cannot fully explain the increased risk but the common underst...

journal_title：Zeitschrift fur Rheumatologie

authors： Pieringer H,Hoppe UC

更新日期：2013-05-01 00:00:00

abstract：:Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump i...

journal_title：Zeitschrift fur Rheumatologie

authors： Korsten P,Müller GA

更新日期：2015-05-01 00:00:00

abstract：:The immune system is regulated by a variety of mechanisms that prevent overwhelming immune responses and a break in tolerance. There have been indications for some time that populations of B cells are also a part of this network and able to exert regulatory functions. Here we summarize current knowledge on this previo...

journal_title：Zeitschrift fur Rheumatologie

authors： Tretter T,Lorenz HM

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Only insufficient data are available regarding the question whether treatment with immunosuppressants or biologicals is feasible and safe in patients with a history of malignancy. METHOD:Literature search via PubMed, EULAR abstracts and ACR abstracts from 2013 to 2015. RESULTS:The Société Francaise de Rh...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmalzing M,Strangfeld A,Tony HP

更新日期：2016-02-01 00:00:00

abstract：:In an intraindividual series of investigation consisting of 30 patients with rheumatoid arthritis the effect of gold therapy (Aurothioglucose) has been proved controlling biochemical and clinical parameters. Controls of the function-index by Steinbrocker et al. have shown a significant improvement in comparison with t...

journal_title：Zeitschrift fur Rheumatologie

authors： Knoche U,Wagner H,Hauss WH

更新日期：1975-05-01 00:00:00

abstract：:A 41-year-old patient with mutilating rheumatoid arthritis and progressive systemic sclerosis, who developed a chronic myeloproliferative disorder polycythemia vera was observed. Some of the pathogenetic aspects of this case with special respect to the function abnormalities of peripheral blood polymorphonuclear cells...

journal_title：Zeitschrift fur Rheumatologie

authors： Hrycaj P,Mackiewicz S

更新日期：1992-09-01 00:00:00

abstract：:Bone metabolic homeostasis is regulated by a number of hormones and local modulators, and the study of these factors has been of major help in our understanding of bone disease. However, these parameters do not, in a strict sense reflect the metabolic and biochemical changes in the diseased bone tissue. Thus, there is...

journal_title：Zeitschrift fur Rheumatologie

authors： Tohmé JF,Seibel MJ,Silverberg SJ,Robins SP,Bilezikian JP

更新日期：1991-05-01 00:00:00

abstract：:Transmitting a substantial amount of basic knowledge in Rheumatology to all medical students is essential for the future medical care of patients with rheumatic diseases for two reasons: on the one hand, future general practitioners will need to master the patterns of rheumatic diseases to recognize them fast enough i...

journal_title：Zeitschrift fur Rheumatologie

authors： Aringer M,Baerwald C,Bergner R,Feuchtenberger M,Gebhardt C,Hagen M,Keyßer G,Lorenz HM,Witte T

更新日期：2020-12-02 00:00:00

abstract：:The biochemical defect leading to alcaptonuria is well known. However, the pathogenesis of ochronotic arthropathy is poorly understood. The present ultrastructural study elucidated the localization of ochronotic pigment in the articular cartilage and evidence was found that suggests a pathway for cartilage destruction...

journal_title：Zeitschrift fur Rheumatologie

authors： Mohr W,Wessinghage D,Lenschow E

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) in Germany is a rare, genetically linked disease of childhood and adolescence, which is characterized by recurrent febrile episodes and clinical signs of peritonitis, pleuritis and arthritis. Treatment with colchicine is effective and well-tolerated in the majority of patie...

journal_title：Zeitschrift fur Rheumatologie

authors： Kallinich T,Blank N,Braun T,Feist E,Kiltz U,Neudorf U,Oommen PT,Weseloh C,Wittkowski H,Braun J

更新日期：2019-02-01 00:00:00

abstract：:Autoreactivity plays a major role in the pathogenesis of RA. The rheumatoid factor has been and still is for now more than 50 years the only autoreactivity that is clinically applied in the diagnosis of RA. This well reflects the current way of thinking that a single antigen or a single cause drives an individual into...

journal_title：Zeitschrift fur Rheumatologie

authors： Bläss S,Engel JM,Burmester GR

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Patients with an inflammatory disease have an elevated risk for periprosthetic joint infections due to impairment of the immune system caused by the disease itself in combination with disease-modifying antirheumatic drugs (DMARD). These infections can cause life-threatening sepsis. Unfortunately recommendati...

journal_title：Zeitschrift fur Rheumatologie

authors： Illgner U,Uekötter A,Bause L

更新日期：2014-06-01 00:00:00

abstract：:The diagnosis of chondrocalcinosis is based on typical radiographic findings and synoviaanalysis. We examined 10 patients with chondrocalcinosis to see whether pathognomonic findings of the disease could also be seen by ultrasound. Ultrasound and x-ray findings were compared. Calcifications of the knee menisci were se...

journal_title：Zeitschrift fur Rheumatologie

authors： Kellner H,Zoller W,Herzer P

更新日期：1990-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease. Standard treatment consists of chronic therapy with antimalarials, glucocorticoids and immunosuppressive/cytotoxic drugs, which is associated with considerable side effects. In contrast, immunoablation of autoreactive immunologic memory follo...

journal_title：Zeitschrift fur Rheumatologie

authors： Alexander T,Arnold R,Hiepe F

更新日期：2009-05-01 00:00:00

abstract：:Autoinflammatory syndromes are characterized by periodic febrile attacks in combination with increased inflammatory markers. The dysregulation of different cellular signaling pathways leads to an excessive immune response, which can in turn promote multisystemic inflammatory processes. Due to overlapping symptoms, var...

journal_title：Zeitschrift fur Rheumatologie

authors： Schnappauf O

更新日期：2020-09-01 00:00:00

abstract：:Recent Deutsche Gesellschaft für Rheumatologie (DGRh, German Society of Rheumatology) guidelines emphasized the significance of coordinated multidisciplinary care and rehabilitation of patients with inflammatory rheumatic diseases. Nationwide data from the German pension insurance funds showed that inpatient rehabilit...

journal_title：Zeitschrift fur Rheumatologie

authors： Mau W,Beyer W,Ehlebracht-König I,Engel JM,Genth E,Jäckel WH,Lange U,Thiele K

更新日期：2014-03-01 00:00:00

abstract：:In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...

journal_title：Zeitschrift fur Rheumatologie

authors： Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

更新日期：1999-08-01 00:00:00

abstract：:In recent years, new findings in immunology have been successfully converted to therapeutic principles, in particular for rheumatoid arthritis (RA) and spondylarthritides. The introduction of cytokine blockers in RA using tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 inhibitors presented the first original ...

journal_title：Zeitschrift fur Rheumatologie

authors： Mei H,Dörner T

更新日期：2009-07-01 00:00:00