[Activity leakage and radiation exposure in radiation synovectomy of the knee: influence of different therapeutic modalities].

Abstract:

:In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclide and, therefore, a higher radiation exposure is possible. In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy, resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 (0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalities resulted in no statistical difference (p>0.05). Because of the found radionuclide emigration, a radiation dose of 0. 1 (0.05-0,18) mSv in women and 0.2 (0.1-0.38) mSv in men was calculated. For lymph nodes, liver, spleen and whole body radiation doses of 619 (154-1644) mSv, 62 (15-165) mSv, 62 (15-165) mSv and 37 (9-99) mSv were calculated. Gonadal radiation dose can be neglected and the morbidity rate for tumors because of the whole body radiation dose is low with a value of 0.4 per thousand. Therefore, radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality.

journal_name

Z Rheumatol

authors

Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

doi

10.1007/s003930050172

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

207-12

issue

4

eissn

0340-1855

issn

1435-1250

pii

90580207.393

journal_volume

58

pub_type

杂志文章
  • [Polyarteritis nodosa: differential diagnostics and therapy].

    abstract::Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium size arteries that may affect various organs. The clinical appearance is very variable. The most common manifestations are of the skin, the peripheral nervous system presenting as mononeuritis multiplex and the mesenteric and renal blood vessels due to t...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-014-1483-z

    authors: Schirmer JH,Holl-Ulrich K,Moosig F

    更新日期:2014-12-01 00:00:00

  • [History of the German Society of Rheumatology 1947-2007].

    abstract::The "German Society of Rheumatology" was founded in Bad Neuenahr in the Federal Republic of Germany In 1947. The society perceived itself as the successor to the "German Society for the Abatement of Rheumatism". The primary aim of the society was close cooperation with other German-speaking rheumatological societies i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 历史文章,杂志文章

    doi:10.1007/s00393-010-0674-5

    authors: Hewelt T

    更新日期:2011-01-01 00:00:00

  • [State of the art and tasks of complex rehabilitation of patients with rheumatic diseases in East Germany].

    abstract::Rehabilitation activities belong to tertiary prevention. The latter includes all measures that aim at avoiding the progression of a physical disability to a handicap, or those that diminish the extent of the handicap. Complex rehabilitation programs represent a cooperation of medical, occupational, and social reintegr...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Wessel G,Leistner K

    更新日期:1990-09-01 00:00:00

  • [Tocilizumab. What comes after TNF-blockers in clinical routine?].

    abstract::Tocilizumab, a monoclonal humanized antibody against IL-6, was licensed in January 2009 in combination with Methotrexate for the treatment of adult patients with moderately to severely active rheumatoid arthritis and inadequate response to one or more DMARDs or TNF antagonists. Tocilizumab is given once every 4 weeks ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-009-0529-0

    authors: Roll P,Rubbert-Roth A,Tony HP

    更新日期:2010-09-01 00:00:00

  • [Pregnancy and inflammatory rheumatic diseases].

    abstract::Inflammatory rheumatic diseases often affect females of childbearing age and pregnancy remains a challenge for this group of patients and their physicians. However, the majority of patients can now have successful pregnancies and deliver healthy babies as a result of our improved knowledge of the risks encountered dur...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-010-0661-x

    authors: Fischer-Betz R,Gromnica-Ihle E

    更新日期:2010-09-01 00:00:00

  • [The enterprising Irishman Bernard Connor (1666-1698)].

    abstract::In the thesis of the Irish physician Bernard Connor (1666-1698) from 1693 in Rheims he describes the torso of a man whose bones were joined together due to ankylosing spondylitis which is considered to be the first example of such skeletal findings. This communication must however be seen in connection with earlier an...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s00393-010-0657-6

    authors: Keitel W

    更新日期:2012-06-01 00:00:00

  • [Paradigm shift in ANCA diagnostics : New international consensus recommendations].

    abstract:BACKGROUND:Up to now indirect immunofluorescence (IIF) followed by an antigen-specific assay specific for proteinase 3 (PR3) or myeloperoxidase (MPO) has been the standard method for the detection of antineutrophil cytoplasmic antibodies (ANCA). The development of more sensitive and highly specific PR3-ANCA and MPO-ANC...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-016-0240-x

    authors: Csernok E,Kempiners N,Hellmich B

    更新日期:2017-03-01 00:00:00

  • [Possibilities and limits of daily coping with illness by patients with chronic polyarthritis].

    abstract::A central problem of persons with chronic polyarthritis is the necessary adaptation to deteriorating health in everyday activities. Difficulties and burdens of this adaptation are parts of the study undertaken in the Unna Model, which was part of the research on "Local Services for CP-Patients". In the first part two ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Grunow-Lutter V,Grunow D

    更新日期:1992-01-01 00:00:00

  • [Biliary, renal and fecal elimination and distribution of gold after a single oral administration of auranofin, quantified by the instrumental neutron activation analysis method].

    abstract::Three days after cholecystectomy, seven patients received a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). At defined time points thereafter the gold content in samples of blood, plasma, urine, bile, and feces was determined by instrumental neutron activation analysis (INAA). Maxima of the mean gold conc...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Benn HP,Schnier C,Bauer E,Seiler KU,Elhöft H,Löffler H

    更新日期:1991-01-01 00:00:00

  • [Enzyme therapy in comparison with immune complex determinations in chronic polyarthritis].

    abstract::42 patients with definite or classic rheumatoid arthritis were treated with an enzyme mixture (Wobenzym) for 6 weeks. Circulating immune complexes were investigated with a Clq-solid phase RIA in weekly intervals and also rheumatoid factors were determined together with other routine laboratory tests. The condition of ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Steffen C,Smolen J,Miehlke K,Hörger I,Menzel J

    更新日期:1985-03-01 00:00:00

  • [Pneumocystis jiroveci pneumonia (PcP) in patients with rheumatic diseases: case report and review].

    abstract::A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-005-0019-y

    authors: Bertisch B,Ruef C

    更新日期:2006-02-01 00:00:00

  • [Intracellular signaling pathways of synovial fibroblasts in rheumatoid arthritis].

    abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease of still unknown etiology that results in characteristic destructive changes of the joints. Research of the past years has demonstrated that synovial fibroblasts play a central role in the initiation and perpetuation of these destructive changes. Stimulation of...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-007-0181-5

    authors: Korb A,Peters M,Meinecke I,Pap T

    更新日期:2007-07-01 00:00:00

  • [Aseptic osteonecrosis after steroid treatment].

    abstract::A 28-year-old female patient had load-dependent pain of the left knee. MRI showed an osteochondral defect of the medial condyle based on extensive osteonecrosis of the femoral and tibial bone. An association with a prior steroid treatment after cervical injury is most likely. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-004-0556-9

    authors: Steinhagen J,Rüther W

    更新日期:2004-06-01 00:00:00

  • [Methotrexate toxicity. Myths and facts].

    abstract::Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying an...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-010-0687-0

    authors: Keysser G

    更新日期:2011-02-01 00:00:00

  • [The other opinion: nephrotoxicity of low-dose methotrexate - a problem which does not exist].

    abstract::The nephrotoxicity of methotrexate (MTX) is a phenomenon which is observed in high-dose therapy for treatment of malignant diseases. Even low-dose MTX therapy for treatment of rheumatic diseases is claimed to cause impairment in renal function. The necessity to adapt the dosage of MTX therapy for renal function disord...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 评论,杂志文章

    doi:10.1007/s00393-011-0909-0

    authors: Fiehn C

    更新日期:2011-12-01 00:00:00

  • [Revised version of the statement by the DGRh on biosimilars-update 2017].

    abstract::The treatment of rheumatic diseases with bioloics has significantly improved the prognosis of patients. Currently, there are 13 preparations available in Germany for the treatment of patients with inflammatory rheumatic diseases. These original preparations generally have-depending on the individual country-15 years o...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-017-0407-0

    authors: Braun J,Lorenz HM,Müller-Ladner U,Schneider M,Schulze-Koops H,Specker C,Strangfeld A,Wagner U,Dörner T

    更新日期:2018-02-01 00:00:00

  • [Trends in rehabilitation of patients with rheumatic diseases in Germany].

    abstract::Recent Deutsche Gesellschaft für Rheumatologie (DGRh, German Society of Rheumatology) guidelines emphasized the significance of coordinated multidisciplinary care and rehabilitation of patients with inflammatory rheumatic diseases. Nationwide data from the German pension insurance funds showed that inpatient rehabilit...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1259-x

    authors: Mau W,Beyer W,Ehlebracht-König I,Engel JM,Genth E,Jäckel WH,Lange U,Thiele K

    更新日期:2014-03-01 00:00:00

  • Chronic synovitis with marked infiltration of granulocytes in a patient with an unusual development of systemic lupus erythematosus.

    abstract::The case described concerns a patient initially presenting the clinical symptoms of rheumatoid arthritis, including the presence of nodules, and slowly developing into systemic lupus erythematosus (SLE). Besides the signs of chronic inflammation in the synovial tissue, many granulocytes and PAS-positive macrophages we...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meijers KA,Eulderink F,van de Putte LB,Wiersema-van Gogh H,de Vries E,Cats A

    更新日期:1979-07-01 00:00:00

  • [Proliferative and metaplastic reactions as tentative reparatory processes in spontaneous arthritis in the mouse].

    abstract::Performing histo-morphologic studies of knee joints in several hundred mice of the strains C57 black, STR/1N and MAGf, showing a disposition for spontaneous osteo-arthrosis, we found tentative reparative processes in many cases. There was a proliferation of cartilage and of the synovial membrane, mostly in the periphe...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Wilhelmi G,Schneider-Faust R

    更新日期:1984-09-01 00:00:00

  • [Informing patients in the German Rheumaliga].

    abstract::The German Rheuma-Liga as the largest patient organisation presents the different ways of informing patients. Patient- education-programs are presented, with a program focussing on social and psychological issues in particular. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-003-1212-5

    authors: Cattelaens K

    更新日期:2003-01-01 00:00:00

  • Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones.

    abstract::A dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis was found in animal models of chronic inflammatory diseases, and the defect was located in more central portions of the HPA axis. This defect of neuroendocrine regulatory mechanisms contributes to the onset of the model disease. Since these first observati...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:

    authors: Straub RH,Schölmerich J,Zietz B

    更新日期:2000-01-01 00:00:00

  • [Relevance of big data for molecular diagnostics].

    abstract::Big data analysis raises the expectation that computerized algorithms may extract new knowledge from otherwise unmanageable vast data sets. What are the algorithms behind the big data discussion? In principle, high throughput technologies in molecular research already introduced big data and the development and applic...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-018-0436-3

    authors: Bonin-Andresen M,Smiljanovic B,Stuhlmüller B,Sörensen T,Grützkau A,Häupl T

    更新日期:2018-04-01 00:00:00

  • The influence of heat and cold on the pain threshold in rheumatoid arthritis.

    abstract::Superficial heat and cold are commonly used therapeutic methods in patients with rheumatoid arthritis. Both procedures have analgesic effect. In 30 inpatients with rheumatoid arthritis the pain threshold was measured before and after warm bath and ice massage. Rheumatoid patients had significantly lower pain threshold...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Curković B,Vitulić V,Babić-Naglić D,Dürrigl T

    更新日期:1993-09-01 00:00:00

  • [Rheumatism and art : Max Slevogt. The bon viveur and artist plagued by gout].

    abstract::The painter Max Slevogt (1868-1932), together with Lovis Corinth and Max Liebermann, was one of the most important representatives of German impressionism. Slevogt, a gourmet who appreciated fine food and good wines, suffered from acute recurrent gouty arthritis starting at the age of 27 years. His medical history is ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s00393-019-00730-0

    authors: Zeidler H

    更新日期:2020-06-01 00:00:00

  • [Patient-centered assessment of functional health in systemic sclerosis -- where are we now?].

    abstract::Self-administered patient-centered questionnaires have been shown to be practical, reliable and valid in terms of evaluating functional limitations in rheumatic diseases. In systemic sclerosis a modified version of the HAQ and condition-specific questionnaires have been used. The Health Assessment Questionnaire (HAQ) ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-004-0674-4

    authors: Sigl T,Ewert T,Stucki G

    更新日期:2004-12-01 00:00:00

  • [Control of penicillamine therapy in patients with chronic polyarthritis through urine disc electrophoresis].

    abstract::D-penicillamine treatment of 50 patients with rheumatoid arthritis with negative ANF tests, was followed by means of protein disk electrophoresis of the urine. In the beginning the urine proteins were analysed every 4 weeks, later at intervals of 3 to 6 months. A glomerular proteinuria, caused by an immune-complex nep...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Rautenstrauch H

    更新日期:1977-11-01 00:00:00

  • [Induction of chemiluminescence of human granulocytes by monocyte factors from patients with chronic polyarthritis and arthrosis].

    abstract::The supernatant of peripheral blood monocytes, cultured with autologous sera from patients with rheumatoid arthritis, stimulates healthy human granulocytes to significantly elevated chemiluminescence (p = 0.05) compared with supernatants of monocytes from osteoarthritic patients or healthy volunteers. Cultures without...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meske S,Bänziger E

    更新日期:1988-05-01 00:00:00

  • Comparison of the efficacy and safety of tofacitinib and baricitinib in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials.

    abstract:OBJECTIVES:The relative efficacy and safety of tofacitinib and baricitinib were assessed in patients with rheumatoid arthritis (RA) with an inadequate response to disease-modifying anti-rheumatic drugs (DMARDs) or biologics. METHODS:We performed a Bayesian network meta-analysis to combine direct and indirect evidence ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-018-0531-5

    authors: Bae SC,Lee YH

    更新日期:2019-08-01 00:00:00

  • [Liberation of the oxygen radical from peripheral human phagocytes (granulocytes and monocytes) in patients with chronic polyarthritis].

    abstract::Monocytes from patients with definite or classical rheumatoid arthritis show a significantly higher release of O2-radicals in the chemiluminescence assay (2925 X 10(3) cpm) than those of healthy volunteers (267 X 10(3) cpm) (p = 0.01). This difference does not appear in a similar test with granulocytes, which in both ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meske S,Maly FE,Estefan M,Müller W

    更新日期:1985-01-01 00:00:00

  • [Indications and options of new immune modulatory therapies for Sjögren's syndrome].

    abstract::Sjögren's syndrome is a systemic inflammatory rheumatic disorder of unknown origin with so far inadequate therapy options. Management of Sjögren's syndrome is still primarily palliative using local symptomatic measures, and if appropriate glucocorticoids, NSAIDs and immunosuppressive drugs. New clues to the pathogenes...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-007-0231-z

    authors: Feist E,Dörner T,Hansen A

    更新日期:2007-12-01 00:00:00