[Translational aspects on the role of B-cells in autoimmune diseases. "From bench to bedside" and "from bed to benchside"].

Abstract:

:In recent years, new findings in immunology have been successfully converted to therapeutic principles, in particular for rheumatoid arthritis (RA) and spondylarthritides. The introduction of cytokine blockers in RA using tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 inhibitors presented the first original therapy modalities in rheumatology, after proliferation-inhibiting drugs, such as methotrexate and cyclophosphamide, had been accepted in oncology. This advance was and is still being extended with the co-stimulation blockade using abatacept and IL-6 receptor inhibition. Anti-CD20 therapies are of particular importance, initially approved for the treatment of non-Hodgkin's lymphoma (NHL), this therapy modality has been approved in recent years for the treatment of RA following the failure of TNF-blockade. However, questions remain regarding the role of B cells in a number of autoimmune diseases, as well as the working principles of B-cell targeted therapy. In this context, close clinical observation of patients has yielded answers to and confirmation of basic scientific concepts.

journal_name

Z Rheumatol

authors

Mei H,Dörner T

doi

10.1007/s00393-009-0436-4

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

364-9

issue

5

eissn

0340-1855

issn

1435-1250

journal_volume

68

pub_type

杂志文章,评审
  • [Pharmacokinetic studies following 2 and 4-week Felbinac gel administration to the knee joint].

    abstract::Twelve patients with osteoarthrosis were locally treated with Felbinac Gel (biphenyl acetic acid (BPAA) 3%) three times daily for 14 days (five patients), 28 days (six patients) or 42 days (one patient) before elective knee joint surgery. BPAA plasma concentrations as of the seventh day of treatment were steady at bet...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Bolten W,Waldorf-Bolten E,Sarfert D,Lehmann W,Miehlke W

    更新日期:1990-11-01 00:00:00

  • [Cytokines].

    abstract::Cytokine driven inflammation is a common feature in autoimmune diseases. Cytokines are needed under physiological conditions within the innate and adaptive immune systems to control infectious diseases and neoplastic disorders by regulation of the cell cycle and apoptosis. Cytokines can also be found in persistently i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-007-0176-2

    authors: Feuchtenberger M,Kneitz C,Tony HP

    更新日期:2007-07-01 00:00:00

  • [The course and topography of pain in generalized tendomyopathies].

    abstract::The generalized tendomyopathy (fibromyalgia) is characterized by the characteristic picture of multilocular pain symptoms, severe pressure-type pain in the tendon insertions and muscles, vitality deficiency, sleep disturbance and other vegetative disorders as well as functional complaints and is often also characteriz...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:

    authors: Brückle W,Lautenschläger J,Müller W

    更新日期:1991-01-01 00:00:00

  • [German patient version of the ASAS/EULAR recommendations for the management of ankylosing spondylitis].

    abstract::The evidence-based recommendations on the management of ankylosing spondylitis (AS) have enjoyed a high level of acceptance and circulation in Germany, as well as in other European countries. To make patient participation in the decision-making process regarding their disease easier, as well as to strengthen the physi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-009-0428-4

    authors: Kiltz U,Feldtkeller E,Braun J

    更新日期:2010-03-01 00:00:00

  • Fatigue in systemic lupus erythematosus : Association with disease activity, quality of life and psychosocial factors.

    abstract:OBJECTIVE:The aim of the study was to determine which disease-related factors and non-disease features can explain the presence of systemic lupus erythematosus (SLE)-related fatigue in Turkish patients. METHODS:This cross-sectional study was carried out with 99 SLE patients and 71 healthy controls. To assess fatigue a...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-016-0185-0

    authors: Yilmaz-Oner S,Ilhan B,Can M,Alibaz-Oner F,Polat-Korkmaz O,Ozen G,Mumcu G,Kremers HM,Tuglular S,Direskeneli H

    更新日期:2017-12-01 00:00:00

  • [Bone morphogenetic proteins in the skeletal system].

    abstract::Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Their potential for organ and tissue regeneration and repair has been intensively investigated in recent years. Studies on fetal development have demonstrated the important role of these proteins for the development and diffe...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-005-0665-0

    authors: Bramlage CP,Häupl T,Kaps C,Bramlage P,Müller GA,Strutz F

    更新日期:2005-09-01 00:00:00

  • [De-escalation of therapy in ANCA-associated vasculitides].

    abstract::Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) require a differentiated therapeutic approach depending on the degree of organ dysfunction and disease activity. In organ dysfunction and life-threatening AAV cyclophosphamide and rituximab are recommended for the induction of remission. For remi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-016-0241-9

    authors: Schinke S,Riemekasten G,Lamprecht P

    更新日期:2017-02-01 00:00:00

  • [Ultrasound study of the elbow joint in patients with chronic inflammatory joint diseases--an enrichment of diagnosis?].

    abstract::After clinical and radiological examination, the elbows of 74 patients with rheumatoid arthritis were examined by ultrasound. Clinical examination gives a good impression of the inflammatory changes of the elbow joint. Sonography was very useful in detecting synovitis and joint effusion and their distribution in the d...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Sell S,König S,Zacher J

    更新日期:1993-05-01 00:00:00

  • The coexistence of mutilating rheumatoid arthritis, progressive systemic sclerosis and polycythemia vera--a case report.

    abstract::A 41-year-old patient with mutilating rheumatoid arthritis and progressive systemic sclerosis, who developed a chronic myeloproliferative disorder polycythemia vera was observed. Some of the pathogenetic aspects of this case with special respect to the function abnormalities of peripheral blood polymorphonuclear cells...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Hrycaj P,Mackiewicz S

    更新日期:1992-09-01 00:00:00

  • The cytokine-HPA axis feed-back circuit.

    abstract::Due to their anti-inflammatory effects and their capacity to affect the synthesis of most cytokines and the Th1/Th2 balance, endogenous glucocorticoids contribute to control the basal operation of immune cells. Immune processes result in the production of cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, a...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s003930070014

    authors: Besedovsky HO,del Rey A

    更新日期:2000-01-01 00:00:00

  • [Why rheumatoid arthritis needs cardiologists].

    abstract::Rheumatoid arthritis (RA) is associated with a shortened life expectancy. Most premature deaths are caused by cardiovascular (CV) events; therefore it is of importance to consider the increased CV risk when treating RA patients. Traditional CV risk factors cannot fully explain the increased risk but the common underst...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1198-6

    authors: Pieringer H,Hoppe UC

    更新日期:2013-05-01 00:00:00

  • [Sport and rheumatoid arthritis].

    abstract:BACKGROUND:Sport is becoming increasingly more important in our society. Due to the changing age spectrum with a greater number of elderly and substantially more active people, an increasing number of people with underlying orthopedic diseases are becoming interested in participating in sport. MATERIAL AND METHODS:Thi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-013-1341-4

    authors: Proschek D,Rehart S

    更新日期:2014-06-01 00:00:00

  • [Healthcare research in rheumatology. Current state].

    abstract::Health services research in rheumatology investigates the healthcare needs, the quality of care and trends in healthcare for patients with musculoskeletal disorders. Using rheumatoid arthritis (RA) as an example, key results of health services research during the last 25 years are summarized. There are currently appro...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1258-y

    authors: Zink A

    更新日期:2014-03-01 00:00:00

  • [The temporomandibular joint from the rheumatologic viewpoint].

    abstract::Temporomandibular joint affections in rheumatic disease are described. They were seen in inflamed joint diseases, mostly in rheumatoid arthritis, and less so in juvenile rheumatoid arthritis, psoriatic arthritis, Reiter's syndrome, ankylosing spondylitis, and collagen vascular disease. In osteoarthrosis, the temporoma...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:

    authors: Wörth WD,Keller B,Graber G,Müller W

    更新日期:1988-03-01 00:00:00

  • [Prospective study of JCR-Oligo I of the Child and Adolescence Rheumatology Working Group].

    abstract::Intra-articular injection of corticosteroids is a powerful anti-inflammatory treatment with relatively few side effects. To date no prospective RCT exists on its use in children with oligoarthritis type I. Thus, in January 2000 the Arbeitsgemeinschaft started a multicenter RCT to compare in children with this diagnosi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/s003930050216

    authors: Forster J

    更新日期:2000-04-01 00:00:00

  • [Imaging procedures in rheumatology: imaging in vasculitis].

    abstract::In small vessel vasculitides, imaging studies aid in determining disease extent and activity, localization for biopsy, and for disease monitoring. They do not directly delineate the vasculitic lesion. Imaging studies focus on the upper and lower respiratory tract. Cranial magnetic resonance imaging (MRI) shows upper r...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-006-0107-7

    authors: Schmidt WA,Both M,Reinhold-Keller E

    更新日期:2006-11-01 00:00:00

  • Orthopädische Rheumatologie.

    abstract:: ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 新闻

    doi:10.1007/s00393-018-0509-3

    authors:

    更新日期:2018-11-01 00:00:00

  • [Blood pressure in arm and finger arteries in rheumatoid arthritis].

    abstract::The pressure load is critical for vascular wall alteration. Systolic blood pressure was measured by Doppler sonography in the finger and arm arteries of 24 patients with rheumatoid arthritis and compared to a control group (n = 22) of nearly the same age. The transmitter frequency of the ultrasound probe was 9.6 MHz. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Beste KW

    更新日期:1985-05-01 00:00:00

  • [Back to school physical education despite rheumatism : Development and testing of a sport scientific-based physical education certification].

    abstract:BACKGROUND:Taking part in physical education is an important element of social participation for children with chronic diseases. Nevertheless, children suffering from rheumatism mostly receive recommendations to stop sport activities either completely or partially, without underlying scientific guidelines. OBJECTIVE:T...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-018-0518-2

    authors: Hartmann M,Merker J,Schrödl S,König M,Georgi M,Hinze C,Schwirtz A,Haas JP

    更新日期:2018-10-01 00:00:00

  • Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA‑G levels and the disease: a meta-analysis.

    abstract:OBJECTIVE:To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS:A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/dele...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-020-00783-6

    authors: Bae SC,Lee YH

    更新日期:2020-04-09 00:00:00

  • [Initial results of the clinical use of the immunostimulant bestatin (3-amino-2-hydroxy-4-phenylbutyryl leucine) in patients with chronic polyarthritis].

    abstract::We tested the efficacy of the immunomodulator Bestatin, which has been successfully applied in Japan, in a preliminary open study in ten patients with classical or definite rheumatoid arthritis. Patients whose arthritis was characterized by a low humoral activity showed a partial remission of the disease after six mon...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meske S,Vogt P,Maly FE,Seitz M,Müller W

    更新日期:1985-09-01 00:00:00

  • [Ultrastructure of hyaline cartilage and articular capsule tissue in alkaptonuric ochronosis].

    abstract::The biochemical defect leading to alcaptonuria is well known. However, the pathogenesis of ochronotic arthropathy is poorly understood. The present ultrastructural study elucidated the localization of ochronotic pigment in the articular cartilage and evidence was found that suggests a pathway for cartilage destruction...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Mohr W,Wessinghage D,Lenschow E

    更新日期:1980-03-01 00:00:00

  • [Lifelong heavy agricultural work and development of arthrosis of the hand--a case study].

    abstract::Heavy physical work load is a known determinant of osteoarthritis of the hip, which may account for the high risk observed among farmers. On the other hand, the data on influence of heavy manual work in the pathogenesis of hand osteoarthritis are still controversial. We examined 25 retired farm laborers who strenuousl...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s003930050193

    authors: Schmid L,Dreier D,Muff B,Allgayer B,Schlumpf U

    更新日期:1999-12-01 00:00:00

  • [Stage oriented surgical cartilage therapy. Current situation].

    abstract::Chondral or osteochondral lesions are typical injuries in orthopaedics and traumatology. Since there is no regeneration of damaged articular cartilage, these lesions can lead to premature osteoarthritis. Therefore, an adequate therapy for these injuries is an important goal. Nowadays, common methods in cartilage thera...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-007-0213-1

    authors: Vogt S,Braun S,Imhoff AB

    更新日期:2007-10-01 00:00:00

  • Behçet's syndrome coexisting with clinically occult ankylosing spondylitis.

    abstract::The case of a 36-year old man with Behçet's disease (BS) for 16 years had low back pain and stiffness in the cervical and lumbar spine. He was diagnosed as having ankylosing spondylitis (AS). In this report we wish to emphasize the clinically occult co-existence of AS in BS and revelation of AS after a long time of BS...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-002-0319-4

    authors: Cimen OB,Sahin G,Biçer A,Erdoğan C

    更新日期:2002-08-01 00:00:00

  • [DRESS syndrome following sulfasalazine treatment].

    abstract::A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1308-5

    authors: Pirklbauer M,Gruber J

    更新日期:2014-03-01 00:00:00

  • [Characteristics of pharmacotherapy of rheumatic diseases in advanced age].

    abstract::Drug treatment in the polymorbid elderly should focus on the more important symptoms. Pharmacokinetic differences should be considered, e.g. a reduced volume of distribution and decreased liver and renal function. Special alterations in the pharmacodynamics with respect to the central nervous system and other organs a...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:

    authors: Breithaupt H

    更新日期:1992-11-01 00:00:00

  • [Acetylcholine receptor antibody in D-penicillamine therapy].

    abstract::Since 1978 a 63-year-old woman with rheumatoid arthritis received D-penicillamine (D-PA) in a daily dose of 250-500 mg (mean 300 mg/d). In 1982 the patient complained of diplopia for several days, the ophthalmological and neurological examinations three days later were normal. In July 1983 she developed a myasthenic s...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Kolarz G,Maida EM

    更新日期:1986-05-01 00:00:00

  • [Association of physical activity with fatigue and functional capacity in patients with rheumatoid arthritis].

    abstract:BACKGROUND:Patients with rheumatoid arthritis (RA) tend to be less physically active. Physical activity has been shown to have a positive impact on disease activity and quality of life and is recommended by the European League Against Rheumatism (EULAR) as an integral component of standard treatment. OBJECTIVE:A cross...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-020-00830-2

    authors: Beider S,Flohr S,Gehlert S,Witte T,Ernst D

    更新日期:2020-06-25 00:00:00

  • [Regenerative potential of human adult precursor cells: cell therapy--an option for treating cartilage defects?].

    abstract::Cell-based therapeutical approaches are already in clinical use and are attracting growing interest for the treatment of joint defects. Mesenchymal stem and precursor cells (MSC) cover a wide range of properties that are useful for the regeneration process of bone and cartilage defects. The following article is an ove...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-008-0396-0

    authors: Dehne T,Tschirschmann M,Lauster R,Sittinger M

    更新日期:2009-05-01 00:00:00