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Non-receptor tyrosine kinases c-Abl and Arg regulate the activity of C/EBPbeta.

Abstract：

:The CCAAT/enhancer-binding protein beta (C/EBPbeta) is a critical transcription factor that regulates gene expression during numerous biological processes, including differentiation, metabolism, homeostasis, proliferation, tumorigenesis, inflammation, and apoptosis. In this study, interactions between C/EBPbeta and either the Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or the Abl-related gene (Arg) were demonstrated in vitro and in vivo with a direct binding assay and by co-immunoprecipitation, respectively. The Y79 amino acid residue of C/EBPbeta was phosphorylated by c-Abl or Arg. The phosphorylation of C/EBPbeta resulted in an increased C/EBPbeta stability and a potentiation of C/EBPbeta transcription activation activity in cells. Expression of the C/EBPbeta(Y79F) mutant in HEK293, and K562, and in other cell lines, resulted in less of a delay in the cell cycle compared to the wild type C/EBPbeta; furthermore, the C/EBPbeta (Y79F) mutant induced an increased apoptosis compared to the wild type C/EBPbeta. These findings suggest that the c-Abl family non-receptor tyrosine kinases have a role in the regulation of the C/EBPbeta transcription factor.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Li X,Liu X,Wang G,Zhu X,Qu X,Li X,Yang Y,Peng L,Li C,Li P,Huang W,Ma Q,Cao C

doi

10.1016/j.jmb.2009.06.055

subject

Has Abstract

pub_date

2009-08-28 00:00:00

pages

729-43

issue

4

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(09)00753-0

journal_volume

391

pub_type

杂志文章

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