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Genes and pseudogenes for rat U3A and U3B small nuclear RNA.

Abstract：

:We report here the isolation and primary structure of two genes encoding rat U3 small nuclear RNA. One of the genes encodes U3B RNA; the other encodes an RNA which is almost identical to U3A RNA. Both genes are expressed after microinjection into the nuclei of Xenopus laevis oocytes and can direct the accumulation of mature U3 RNA as well as longer transcripts which may be the U3 precursors. We have also isolated and sequenced four other regions of the rat genome homologous to U3 RNA. One of these almost certainly represents a second U3B gene; the other three are pseudogenes which appear to have been generated by the reverse flow of genetic information from U3 RNA back into the genome. Using genomic blotting techniques, we show that the rat U3 genes are present in only a few copies per haploid genome and are probably not closely linked to one another.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Stroke IL,Weiner AM

doi

10.1016/0022-2836(85)90372-9

subject

Has Abstract

pub_date

1985-07-20 00:00:00

pages

183-93

issue

2

eissn

0022-2836

issn

1089-8638

pii

0022-2836(85)90372-9

journal_volume

184

pub_type

杂志文章

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