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Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses.

Abstract：

:Viral hemorrhagic fevers caused by emerging RNA viruses of the Arenavirus family are among the most devastating human diseases. Climate change, global trade, and increasing urbanization promote the emergence and re-emergence of these human pathogenic viruses. Emerging pathogenic arenaviruses are of zoonotic origin and reservoir-to-human transmission is crucial for spillover into human populations. Host cell attachment and entry are the first and most fundamental steps of every virus infection and represent major barriers for zoonotic transmission. During host cell invasion, viruses critically depend on cellular factors, including receptors, co-receptors, and regulatory proteins of endocytosis. An in-depth understanding of the complex interaction of a virus with cellular factors implicated in host cell entry is therefore crucial to predict the risk of zoonotic transmission, define the tissue tropism, and assess disease potential. Over the past years, investigation of the molecular and cellular mechanisms underlying host cell invasion of human pathogenic arenaviruses uncovered remarkable viral strategies and provided novel insights into viral adaptation and virus-host co-evolution that will be covered in the present review.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Fedeli C,Moreno H,Kunz S

doi

10.1016/j.jmb.2018.04.026

subject

Has Abstract

pub_date

2018-06-22 00:00:00

pages

1839-1852

issue

13

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(18)30299-7

journal_volume

430

pub_type

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