Abstract:
:Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologically related to inflammation. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. In the tumor microenvironment, smoldering inflammation contributes to proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, reduced response to hormones and chemotherapeutic agents. Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells. In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Colotta F,Allavena P,Sica A,Garlanda C,Mantovani Adoi
10.1093/carcin/bgp127subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1073-81issue
7eissn
0143-3334issn
1460-2180pii
bgp127journal_volume
30pub_type
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