Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1).

abstract：:A congenitally abnormal fibrinogen was isolated from blood of a young man with deep-vein thrombosis. Two other affected members of his family had three episodes of severe arterial thrombosis. The fibrinogen showed a delayed clotting by thrombin, but a normal clotting by Arvin, Reptilase, and prothrombin-staphylocoagul...

journal_title：Thrombosis and haemostasis

authors： Haverkate F,Koopman J,Kluft C,D'Angelo A,Cattaneo M,Mannucci PM

更新日期：1986-02-28 00:00:00

abstract：:Herpes simplex virus (HSV) infection is histopathologically associated with vascular injury, fibrinoid necrosis and inflammatory cell infiltrates. We have previously shown in vitro that HSV infection of human umbilical vein endothelial cells (HUVEC) promotes a procoagulant phenotype manifest by the induction of tissue...

journal_title：Thrombosis and haemostasis

authors： Bok RA,Jacob HS,Balla J,Juckett M,Stella T,Shatos MA,Vercellotti GM

更新日期：1993-03-01 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the c...

journal_title：Thrombosis and haemostasis

authors： de Jong A,Dirven RJ,Boender J,Atiq F,Anvar SY,Leebeek FWG,van Vlijmen BJM,Eikenboom J

更新日期：2020-11-01 00:00:00

abstract：:To study the predictive value of coagulation markers concerning clinical outcome, prothrombin fragment F1.2 (F1.2), fibrin monomer antigen (FM), D-Dimer (DD), and fibrinogen were measured in plasma samples drawn 2 and 7 days after acute myocardial infarction (AMI) in 314 consecutive patients randomized in a clinical t...

journal_title：Thrombosis and haemostasis

authors： Dempfle CE,Kontny F,Abildgaard U

更新日期：1999-05-01 00:00:00

abstract：:Current thrombolytic strategies have a number of important shortcomings including resistance to recanalization and development of acute reocclusion. The purpose of this study was to investigate whether the lysis of venous thrombi by streptokinase could be enhanced by SR 46349, a novel 5-HT2 receptor antagonist, or clo...

journal_title：Thrombosis and haemostasis

authors： Herbert JM,Bernat A,Sainte-Marie M,Dol F,Rinaldi M

更新日期：1993-03-01 00:00:00

abstract：:Defibrotide is an antithrombotic drug which enhances prostacyclin production and activates fibrinolytic system. The aim of this study was to investigate the improvement of walking distance in patients with intermittent claudication treated with defibrotide. DICLIS was a double blind, placebo-controlled study which inc...

journal_title：Thrombosis and haemostasis

authors： Violi F,Marubini E,Coccheri S,Nenci GG

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND: Evaluation of thromboembolic risk is essential in anticoagulated atrial fibrillation (AF) patients. The CHA2DS2-VASc score is largely validated and recommended by most guidelines. The GARFIELD-AF Stroke score has been proposed as an alternative risk score. METHODS: We analyzed warfarin-treated patients fro...

journal_title：Thrombosis and haemostasis

authors： Proietti M,Rivera-Caravaca JM,Esteve-Pastor MA,Marín F,Lip GYH

更新日期：2020-12-09 00:00:00

abstract：:In this study, the clot accumulation properties of liposome-coupled plasminogen were compared to those of free (non-liposomal) plasminogen in an in vitro, closed-loop, flow-system. After introduction of a clot into the closed system, double-radiolabelled plasminogen-liposomes were administered and the accumulation of ...

journal_title：Thrombosis and haemostasis

authors： Heeremans JL,Prevost R,Feitsma H,Kluft C,Crommelin DJ

更新日期：1998-01-01 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:Experimental studies have suggested that TNF alpha, a pro-inflammatory cytokine, may contribute to the deterioration of cardiovascular function through various mechanisms, including the generation of reactive oxygen species. It has not yet been demonstrated whether TNF alpha has prooxidant activity in patients with he...

journal_title：Thrombosis and haemostasis

authors： De Biase L,Pignatelli P,Lenti L,Tocci G,Piccioni F,Riondino S,Pulcinelli FM,Rubattu S,Volpe M,Violi F

更新日期：2003-08-01 00:00:00

abstract：:Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor V(Leiden) (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns. Pregnant women with known thrombophilia (n=27) were enro...

journal_title：Thrombosis and haemostasis

authors： Hyytiäinen S,Wartiovaara-Kautto U,Ulander VM,Kaaja R,Heikinheimo M,Petäjä J

更新日期：2006-03-01 00:00:00

abstract：:At the moment of hemostasis, the platelet must be able to reorganize its cytoskeleton through a complexly orchestrated signaling cascade that is regulated, in part, by polyphosphoinositides. In the past 6 years, evidence has accumulated that PH domains bind these polyphosphoinositides and play a role in cytoskeletal c...

journal_title：Thrombosis and haemostasis

authors： Ma AD,Abrams CS

更新日期：1999-08-01 00:00:00

abstract：:Antiphospholipid-protein antibodies (APA) include lupus-type anticoagulant (LA) and antibodies recognizing complexes of anionic phospholipids (e.g. cardiolipin) and proteins (e.g. prothrombin and beta2-glycoprotein I). The presence of APA is associated with an increased risk of both arterial and venous thrombosis. How...

journal_title：Thrombosis and haemostasis

authors： Musiał J,Swadźba J,Jankowski M,Grzywacz M,Bazan-Socha S,Szczeklik A

更新日期：1997-10-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here...

journal_title：Thrombosis and haemostasis

authors： Di Sabatino A,Santilli F,Guerci M,Simeone P,Ardizzone S,Massari A,Giuffrida P,Tripaldi R,Malara A,Liani R,Gurini E,Aronico N,Balduini A,Corazza GR,Davì G

更新日期：2016-08-30 00:00:00

abstract：:There is much debate over the appropriateness of prescribing prolonged anticoagulation to heterozygous carriers of factor V Leiden suffering a first episode of deep vein thrombosis (DVT). We, thus used meta-analysis to estimate from six eligible studies the summary odds-ratio of recurrent DVT in carriers of factor V L...

journal_title：Thrombosis and haemostasis

authors： Marchetti M,Pistorio A,Barosi G

更新日期：2000-11-01 00:00:00

abstract：:Women with a history of venous thromboembolism (VTE), thrombophilia or both may be at increased risk of thrombosis during pregnancy, but the optimal management strategy is not well defined in clinical guidelines because of limited trial data. A strategy of risk assessment and heparin prophylaxis was evaluated in pregn...

journal_title：Thrombosis and haemostasis

authors： Bauersachs RM,Dudenhausen J,Faridi A,Fischer T,Fung S,Geisen U,Harenberg J,Herchenhan E,Keller F,Kemkes-Matthes B,Schinzel H,Spannagl M,Thaler CJ,EThIG Investigators.

更新日期：2007-12-01 00:00:00

abstract：:The efficacy and safety of dabigatran for treatment of venous thromboembolism (VTE) were demonstrated in two trials. It is unclear if the results pertain to patients with cancer and VTE. Data from two randomised trials comparing dabigatran and warfarin for acute VTE were pooled. Primary efficacy outcome was symptomati...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Goldhaber SZ,Kearon C,Kakkar AK,Schellong S,Eriksson H,Hantel S,Feuring M,Kreuzer J

更新日期：2015-07-01 00:00:00

abstract：:Electronic free platelet counting was more sensitive than turbidimetry to detect collagen-induced platelet activation in human platelet-rich plasma. Purified human C1q exhibited a greater inhibitory effect on collagen-induced platelet aggregation in turbidimetry than free platelet counting. Because the change from sma...

journal_title：Thrombosis and haemostasis

authors： Csako G,Suba EA

更新日期：1987-08-04 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been associated with thrombosis and pregnancy losses in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. It has been proposed that aPL may affect endothelia...

journal_title：Thrombosis and haemostasis

authors： Pierangeli SS,Liu X,Espinola R,Olee T,Zhu M,Harris NE,Chen PP

更新日期：2000-09-01 00:00:00

abstract：:Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphism...

journal_title：Thrombosis and haemostasis

authors： Pomp ER,Doggen CJ,Vos HL,Reitsma PH,Rosendaal FR

更新日期：2009-01-01 00:00:00

abstract：:Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe and life-threatening complication of hematopoietic cell transplantation (HCT) that often coincides with graft-versus-host-disease (GVHD). Although endothelial damage seems to be the common denominator for both disorders, the role of complement syste...

journal_title：Thrombosis and haemostasis

authors： Gavriilaki E,Chrysanthopoulou A,Sakellari I,Batsis I,Mallouri D,Touloumenidou T,Papalexandri A,Mitsios A,Arampatzioglou A,Ritis K,Brodsky RA,Mitroulis I,Anagnostopoulos A

更新日期：2019-09-01 00:00:00

abstract：:The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003...

journal_title：Thrombosis and haemostasis

authors： Kenet G,Waldman D,Lubetsky A,Kornbrut N,Khalil A,Koren A,Wolach B,Fattal A,Kapelushnik J,Tamary H,Yacobovitch J,Raveh E,Revel-Vilk S,Toren A,Brenner B

更新日期：2004-10-01 00:00:00

abstract：:Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involv...

journal_title：Thrombosis and haemostasis

authors： Lethagen S,Isaksson C,Schaedel C,Holmberg L

更新日期：2002-09-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) plays a crucial role in haemostasis by regulating TF-induced initiation of coagulation. Since it is expressed by endothelial and trophoblastic cells, TFPI is of particular importance at the placental level and might be involved in the occurrence of gestational vascular complicati...

journal_title：Thrombosis and haemostasis

authors： Ittel A,Bretelle F,Gris JC,Chau C,Sébahoun G,Boubli L,Arnoux D

更新日期：2011-01-01 00:00:00

abstract：:The release of microvesicles ('platelet microparticles', PMPs) by activated platelets has been shown to be an integral part of the thrombotic process. PMPs are believed to mediate many biological processes as they possess various platelet membrane proteins and bioactive lipids. Of note, there is a growing body of evid...

journal_title：Thrombosis and haemostasis

authors： Tan KT,Lip GY

更新日期：2005-09-01 00:00:00

abstract：:Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular injury. Recent observations of neutrophil extracellular traps (NETs) formation and its mutual reactions with platelet thrombi adds more cl...

journal_title：Thrombosis and haemostasis

authors： Ghasemzadeh M,Hosseini E

更新日期：2015-06-01 00:00:00

abstract：:We have previously reported that platelets from bleeding Simmental cattle do not aggregate in vitro in response to ADP, collagen and calcium ionophore A23187, though calcium mobilization and myosin light chain phosphorylation do occur. The aggregation abnormality, measured by aggregometry, was ascribed to abnormal cyt...

journal_title：Thrombosis and haemostasis

authors： Frojmovic MM,Wong T,Searcy GP

更新日期：1996-12-01 00:00:00

abstract：:Primary immune thrombocytopaenia (ITP) is the most common haemorrhagic disease. Although most patients respond initially to mainstream therapies, such as corticosteroids, immunosuppressants or rituximab, a large proportion of patients fail to respond or relapse. These treatments only affect B lymphocytes or short-live...

journal_title：Thrombosis and haemostasis

authors： Li G,Wang S,Li N,Liu Y,Feng Q,Zuo X,Li X,Hou Y,Shao L,Ma C,Gao C,Hou M,Peng J

更新日期：2018-10-01 00:00:00

abstract：:To find if there is a relation between levels of haemostatic variables at low and high hormonal levels (oestradiol and progesterone) in an individual, blood samples were drawn from 12 women repeatedly during one menstrual cycle (Study I) and from 14 women undergoing in vitro fertilization, before hormonal stimulation ...

journal_title：Thrombosis and haemostasis

authors： Andersson O,Blombäck M,Bremme K,Wramsby H

更新日期：1997-05-01 00:00:00

abstract：:We have recently reported the short-term intraindividual variability of several coagulation factors and inhibitors included in the ARIC study (Chambless et al. Ann Epidemiol 1992; 2:723). In this paper, we reported the intraindividual variability results of additional hemostatic factors. Blood samples were collected f...

journal_title：Thrombosis and haemostasis

authors： Nguyen ND,Ghaddar H,Stinson V,Chambless LE,Wu KK

更新日期：1995-02-01 00:00:00