Clot accumulation characteristics of plasminogen-bearing liposomes in a flow-system. Groningen Utrecht Institute for Drug Exploration.

abstract：:The activation of factor XI by meizothrombin was investigated using recombinant meizothrombin (R155A meizothrombin) that is resistant to autocatalytic removal of fragment 1. Meizothrombin was capable of activating factor XI at an activation rate similar to that of thrombin. Dextran sulphate and heparin, known cofactor...

journal_title：Thrombosis and haemostasis

authors： von dem Borne PA,Mosnier LO,Tans G,Meijers JC,Bouma BN

更新日期：1997-08-01 00:00:00

abstract：:In consecutive patients with suspected venous thromboembolism the interobserver variability of the SimpliRED D-dimer test was evaluated by two observers who independently scored one plate, the between assay variation was performed simultaneously by a third independent observer, who assessed a second plate. The biologi...

journal_title：Thrombosis and haemostasis

authors： Turkstra F,van Beek EJ,Büller HR

更新日期：1998-01-01 00:00:00

abstract：:The effects on the haemoglobin level of low dose aspirin and of low intensity oral anticoagulation with warfarin separately and in combination have been established in men aged between 45 and 69 at high risk of ischaemic heart disease. The findings confirm that combined treatment with warfarin and aspirin (WA) leads t...

journal_title：Thrombosis and haemostasis

authors： Meade TW,Howarth DJ,Brennan PJ

更新日期：1994-03-01 00:00:00

abstract：:The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. ...

journal_title：Thrombosis and haemostasis

authors： oude Egbrink MG,Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1988-02-25 00:00:00

abstract：:Coumarin oral anticoagulant drugs have proven to be effective for the prevention of thromboembolic events. World-wide, warfarin is the most prescribed drug. In Europe, acenocoumarol and phenprocoumon are also administered. Yet it has been proven that variant alleles of the VKORC1 and CYP2C9 genotypes influence the pha...

journal_title：Thrombosis and haemostasis

authors： Beinema M,Brouwers JR,Schalekamp T,Wilffert B

更新日期：2008-12-01 00:00:00

abstract：:Tamoxifen is a known anti-cancer drug and established estrogen receptor modulator. Few clinical studies have earlier implicated the drug in thrombotic complications attributable to lower anti-thrombin and protein S levels in plasma. However, action of tamoxifen on platelet signalling machinery has not been elucidated ...

journal_title：Thrombosis and haemostasis

authors： Nayak MK,Singh SK,Roy A,Prakash V,Kumar A,Dash D

更新日期：2011-10-01 00:00:00

abstract：:Emicizumab, a humanised bispecific antibody recognising factors (F) IX/IXa and X/Xa, can accelerate FIXa-catalysed FX activation by bridging FIXa and FX in a manner similar to FVIIIa. However, details of the emicizumab-antigen interactions have not been reported so far. In this study, we first showed by surface plasmo...

journal_title：Thrombosis and haemostasis

authors： Kitazawa T,Esaki K,Tachibana T,Ishii S,Soeda T,Muto A,Kawabe Y,Igawa T,Tsunoda H,Nogami K,Shima M,Hattori K

更新日期：2017-06-28 00:00:00

abstract：:In the AMPLIFY clinical trial, apixaban was non-inferior to warfarin plus subcutaneous enoxaparin bridge therapy in the treatment of acute venous thromboembolism (VTE) and was associated with significantly less bleeding. This study evaluated their comparative effectiveness and safety in routine clinical practice. A ma...

journal_title：Thrombosis and haemostasis

authors： Weycker D,Li X,Wygant GD,Lee T,Hamilton M,Luo X,Vo L,Mardekian J,Pan X,Burns L,Atwood M,Hanau A,Cohen AT

更新日期：2018-11-01 00:00:00

abstract：:Factor IXa (FIXa) is a vitamin K-dependent coagulation serine protease which binds to factor VIIIa (FVIIIa) on negatively charged phospholipid vesicles (PCPS) to catalyse the activation of factor X (FX) to factor Xa (FXa) in the intrinsic pathway. Fluorescence resonance energy transfer (FRET) studies have indicated th...

journal_title：Thrombosis and haemostasis

authors： Qureshi SH,Yang L,Rezaie AR

更新日期：2012-12-01 00:00:00

abstract：:Interactions between proteins and heparin(-like) structures involve electrostatic forces and structural features. Based on charge distributions in the linear sequence of protein C inhibitor (PCI), two positively charged regions of PCI were proposed as possible candidates for this interaction. The first region, the A+ ...

journal_title：Thrombosis and haemostasis

authors： Elisen MG,Maseland MH,Church FC,Bouma BN,Meijers JC

更新日期：1996-05-01 00:00:00

abstract：:Fibrin D-Dimer (D-Di), prothrombin activation fragment (F 1+2) and thrombin-antithrombin III complexes (TAT) were measured using ELISA procedures in the plasma of patients with an acute deep venous thrombosis (DVT), at presentation and on days 2, 6 and 10 after initiation of heparin treatment. Patients were randomly a...

journal_title：Thrombosis and haemostasis

authors：

更新日期：1993-12-20 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa; NovoSeven®) is a heterogeneously glycosylated serine protease used for treatment of haemophiliacs with inhibitors. The drug substance contains a subpopulation consisting of ~20% of rFVIIa molecules which are unsialylated and consists of carbohydrate moieties with terminally ex...

journal_title：Thrombosis and haemostasis

authors： Seested T,Nielsen HM,Christensen EI,Appa RS

更新日期：2010-12-01 00:00:00

abstract：:Intraoperative high-dose aprotinin administration has been shown to reduce the intra-and postoperative blood loss in cardiac surgery. The haemostatic effect has been attributed to platelet preserving properties and to inhibition of contact activation reducing thrombotic and fibrinolytic activity during and after cardi...

journal_title：Thrombosis and haemostasis

authors： Spannagl M,Dooijewaard G,Dietrich W,Kluft C

更新日期：1995-05-01 00:00:00

abstract：:Bypassing inhibitors in haemophilia patients is limited to activated (a) Factor(F)VII products. We introduced "FVa activity augmentation" as another bypassing strategy and studied effects of an engineered FVa variant designated superFVa. Procoagulant and clot stabilising properties of superFVa and recombinant human (r...

journal_title：Thrombosis and haemostasis

authors： Bhat V,von Drygalski A,Gale AJ,Griffin JH,Mosnier LO

更新日期：2016-03-01 00:00:00

abstract：:Viper venoms contain a variety of platelet binding proteins including those which bind to platelet GPIb/GPIX. Most of these proteins inhibit von Willebrand factor mediated platelet agglutination. Here we report the primary structures of unique members of this family, alboaggregins A and B, isolated from Trimeresurus a...

journal_title：Thrombosis and haemostasis

authors： Kowalska MA,Tan L,Holt JC,Peng M,Karczewski J,Calvete JJ,Niewiarowski S

更新日期：1998-03-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) plays a crucial role in haemostasis by regulating TF-induced initiation of coagulation. Since it is expressed by endothelial and trophoblastic cells, TFPI is of particular importance at the placental level and might be involved in the occurrence of gestational vascular complicati...

journal_title：Thrombosis and haemostasis

authors： Ittel A,Bretelle F,Gris JC,Chau C,Sébahoun G,Boubli L,Arnoux D

更新日期：2011-01-01 00:00:00

abstract：:Clot retraction is an essential step during primary haemostasis, thereby promoting thrombus stability and wound healing. Integrin αIIbβ3 plays a critical role in clot retraction, by inducing acto-myosin interactions that allow platelet cytoskeleton reorganisation. However, the signalling pathways that lead to clot ret...

journal_title：Thrombosis and haemostasis

authors： Egot M,Kauskot A,Lasne D,Gaussem P,Bachelot-Loza C

更新日期：2013-12-01 00:00:00

abstract：:There is no patient-reported medication adherence measure that has been validated in Singapore. This study aimed to validate the 8-item Morisky Medication Adherence Scale (MMAS) in patients taking warfarin in Singapore. A cross-sectional survey was conducted in a convenience sample of 151 patients taking warfarin at a...

journal_title：Thrombosis and haemostasis

authors： Wang Y,Kong MC,Ko Y

更新日期：2012-10-01 00:00:00

abstract：:In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin cytoskeletal structures - stress fibers, lamellipodia and filopodia - to complex integrators of cytoskeletal structures that can exert multiple functions dependi...

journal_title：Thrombosis and haemostasis

authors： Beckers CM,van Hinsbergh VW,van Nieuw Amerongen GP

更新日期：2010-01-01 00:00:00

abstract：:High heparin cofactor II (HCII) activity has recently been described to protect from coronary instent restenosis, presumably by inactivating thrombin in injured arteries. In this study, we investigated the association of HCII activity and restenosis after femoropopliteal stenting. We studied 63 consecutive patients wi...

journal_title：Thrombosis and haemostasis

authors： Schillinger M,Exner M,Sabeti S,Mlekusch W,Amighi J,Handler S,Quehenberger P,Kalifeh N,Wagner O,Minar E

更新日期：2004-11-01 00:00:00

abstract：:The incidence of newly diagnosed malignancy is increased in patients with unexplained venous thromboembolism during the first year after a thromboembolic event in comparison to controls (odds ratio, 3.9-36). Extensive screening with computed tomography, endoscopy and tumor markers can identify most of these undetected...

journal_title：Thrombosis and haemostasis

authors： Prins MH,Hettiarachchi RJ,Lensing AW,Hirsh J

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND: Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors...

journal_title：Thrombosis and haemostasis

authors： Coelho-Lima J,Mohammed A,Cormack S,Jones S,Das R,Egred M,Panahi P,Ali S,Spyridopoulos I

更新日期：2018-07-01 00:00:00

abstract：:S. aureus produces and secretes a protein, extracellular fibrinogen binding protein (Efb), which contributes to virulence in wound infection. We have shown here that Efb is a potent inhibitor of platelet aggregation. Efb can bind specifically to platelets by two mechanisms; 1) to fibrinogen naturally bound to the surf...

journal_title：Thrombosis and haemostasis

authors： Shannon O,Flock JI

更新日期：2004-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a mitogen for endothelial cells. We have studied the production of VEGF by human macrophages in response to lipopolysaccharide (LPS). Macrophages stimulated with LPS expressed VEGF mRNA and protein in concentration- and time-dependent manners. The LPS-induced expression of ...

journal_title：Thrombosis and haemostasis

authors： Itaya H,Imaizumi T,Yoshida H,Koyama M,Suzuki S,Satoh K

更新日期：2001-01-01 00:00:00

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:Monospecific antisera against the purified protein component of tissue thromboplastin (apoprotein-III) from human brain have been raised in goats and rabbits. The antisera neutralized tissue thromboplastin prepared from brain, thyroid gland and pulmonary tissue, indicating that apoproteins in the various preparations ...

journal_title：Thrombosis and haemostasis

authors： Bjorklid E,Storm-Mathisen J,Storm E,Prydz H

更新日期：1977-02-28 00:00:00

abstract：:Von Willebrand factor (vWF) plays an essential role in platelet adhesion and thrombus formation. Patients with atrial fibrillation (AF) exhibit higher plasma vWF and lower ADAMTS13 antigen levels compared to controls. Little is known about vWF and ADAMTS13 in AF patients treated with cardioversion (CV). Thus we invest...

journal_title：Thrombosis and haemostasis

authors： Freynhofer MK,Bruno V,Jarai R,Gruber S,Höchtl T,Brozovic I,Farhan S,Wojta J,Huber K

更新日期：2011-03-01 00:00:00

abstract：:Anisoylated Lys-plasminogen streptokinase activator complex (APSAC) was purified from Eminase by chromatography on Superose-12. Purified APSAC did not significantly deacylate within 4 h at 4 degrees C in solution as determined by hydrolysis of D-Val-L-leu-L-lys-p-nitroanilide HCl (S-2251). At 37 degrees C, maximum ami...

journal_title：Thrombosis and haemostasis

authors： Vasudevan J,Humphries JE,Gonias SL

更新日期：1993-04-01 00:00:00

abstract：:We have previously shown that human platelets express matrix metalloproteinase-2 (MMP-2) and that the release of this enzyme during platelet activation mediates the ADP- and thromboxane-independent part of aggregation. We have now used immunogold electron microscopy, flow cytometry. Western blot analysis and zymograph...

journal_title：Thrombosis and haemostasis

authors： Sawicki G,Sanders EJ,Salas E,Wozniak M,Rodrigo J,Radomski MW

更新日期：1998-11-01 00:00:00

abstract：:A new method to determine the concentration of free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assa...

journal_title：Thrombosis and haemostasis

authors： Giri TK,Hillarp A,Härdig Y,Zöller B,Dahlbäck B

更新日期：1998-04-01 00:00:00